Description of Research Expertise:
My current cardiovascular research interests fall into 3 areas:
1. Cellular metabolic engineering. We are examining the relationship between cellular metabolic function and cellular mechanical function. Our goal is to understand mitochondrial function and cellular bioenergetics in the face of cellular mechanical dysfunction and to understand maintenance of cellular mechanical homeostasis when cellular metabolic capacity becomes stressed.
2. Optimization of nanocarrier design for targeted vascular drug delivery. We are using a combination of experimental and computational techniques to assess the influence of design parameters (e.g., carrier type, size, shape, surface density of targeting binding molecules) to optimize carrier binding to vascular endothelium for targeted drug delivery.
3. Biomimetic macromolecular surface grafting for biocompatibility and anti-infectivity of vascular biomaterials. We are making biomimetic surface molecular constructs of biomacromolecules having bioresponsive swelling properties for drug elution. These thin film layers can be grafted onto solid substrates (e.g., vascular stents, grafts, catheters, extracorporeal perfusion circuits) to improve biocompatibility and reduce bioresponses to blood contact to coated biomaterials as well as to resist and respond to bacterial biofilm formation.
Kandel, J., Picard, M., Wallace, D.C., Eckmann, D.M.: MtDNA 3243A>G heteroplasmy is associated with changes in cytoskeletal protein expression and cell mechanics Journal of the Royal Society Interface 14 (20170071): 2017.
Grady, M.E., Parrish, E., Seeger, S., Caporizzo, M.A., Composto, R.J.*, Eckmann, D.M.*: Intracellular nanoparticle dynamics affected by cytoskeletal integrity Soft Matter 13 : 1873-1880,2017.
Grady, M.E., Composto, R.J., Eckmann, D.M.: Cell elasticity with altered cytoskeletal architectures across multiple cell types Journal of Mechanical Behavior of Biomedical Material 61 : 197-207,2016.
Kandel, J., Angelin, A.A., Wallace, D.C., Eckmann, D.M.: Mitochondrial respiration is sensitive to cytoarchitectural breakdown Integrative Biology 8 : 1170-1182,2016.
Kandel, J., Chou, P., Eckmann, D.M.: Automated detection of whole-cell mitochondrial motility and its dependence on cytoarchitectural integrity Biotechnology & Bioengineering 112 (7): 1395-1405,2015.
Lee, H.S., Dastgheyb, S.S., Hickok, N.J., Eckmann, D.M.,* Composto, R.J.*: Controlled and localized release of Tobramycin from a stimuli-responsive grafted bilayer challenged with S. aureus Biomacromolecules 16 (2): 650-659,2015 .
Coll Ferrer, M.C., Zern, B., Composto, R.J., Muzykantov, V.R., Eckmann, D.M.: ICAM-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation PLoS ONE 9 (7): e102329,2014.
Kandel, J., Lee, H.S., Sobolewski, P., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Chemically grafted fibronectin for use in QCM-D cell studies Biosensors and Bioelectronics 58 : 249-257,2014.
Lee, H.S., Stachelek, S.J., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Correlating macrophage morphology and cytokine production resulting from biomaterial contact Journal of Biomedical Materials Research Part A 101 (1): 203-212,2013.
Coll Ferrer, M.C., Hickok, N.J., Eckmann, D.M., Composto, R.J.: Antibacterial biomimetic hybrid films Soft Matter 8 : 2423-2431,2012.
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