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David M. Eckmann, MD

David M. Eckmann, MD Physician

Horatio C. Wood Professor of Anesthesiology and Critical Care

Dr. Eckmann is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Anesthesiology

Programs & Centers:

Board Certification:

  • Anesthesiology, 1997

Description of Clinical Expertise

Anesthesiology, airway management, regional anesthesia, bariatrics, obesity

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Northwestern University Feinberg School of Medicine
Residency: The Evanston Hospital
Residency: Northwestern Medical Center

Memberships

American Heart Association, International American Society of Anesthesiologists, International Association of University Anesthesiologists, National Biomedical Engineering Society, International Biophysical Society, International Committee on Credible Practice of Modeling & Simulation in Healthcare; Interagency Modeling and Analysis Group/Multiscale Modeling Consortium, National Czech Science Foundation, International Deutsche Forschungsgemeinschaft (German Research Foundation), International IMAG/MSM Consortium Clinical and Translational Issues Working Group, National Interagency Modeling and Analysis Group (NIH/NSF/DOE/NASA/DOD/USDA/FDA), National International Anesthesia Research Society, International John Morgan Society (University of Pennsylvania), Local NASA Cardiovascular Alterations in Flight Panel, International NASA Integrated Physiology and Clinical Operational Flight Panel, International NASA National Space Biomedical Research Institute Five-Year Review Committee, National NASA NNJ13ZSA002N International Life Sciences Research Award (ILSRA) Review Panel , International National Institute of General Medical Sciences Special Emphasis Panel 2012/05 ZGM1 BRT-X (KR), National National Institutes of Health Special Emphasis Panel/Scientific Review Group 2009/08 ZGM1 BRT-0 (LR), National National Institutes of Health Special Review Panel for Challenge Grants, National National Institutes of Health, National Natural Sciences and Engineering Research Council of Canada (NSERC), International NIH Cell Biology, Developmental Biology, and Bioengineering Special Emphasis Panel 2015/01 ZRG1 F05-R (20) L, National NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Special Emphasis Panel 2014/06 2014/10 ZDK1 GRB-S (O3) R, National Pennsylvania Society of Anesthesiologists, Local Philadelphia Pediatric Medical Device Consortium, Local The Whitaker Foundation, National US-Israel Binational Science Foundation, International

Hospital Affiliation

Dr. Eckmann is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

My current cardiovascular research interests fall into 3 areas:

1. Cellular metabolic engineering. We are examining the relationship between cellular metabolic function and cellular mechanical function. Our goal is to understand mitochondrial function and cellular bioenergetics in the face of cellular mechanical dysfunction and to understand maintenance of cellular mechanical homeostasis when cellular metabolic capacity becomes stressed.

2. Optimization of nanocarrier design for targeted vascular drug delivery. We are using a combination of experimental and computational techniques to assess the influence of design parameters (e.g., carrier type, size, shape, surface density of targeting binding molecules) to optimize carrier binding to vascular endothelium for targeted drug delivery.

3. Biomimetic macromolecular surface grafting for biocompatibility and anti-infectivity of vascular biomaterials. We are making biomimetic surface molecular constructs of biomacromolecules having bioresponsive swelling properties for drug elution. These thin film layers can be grafted onto solid substrates (e.g., vascular stents, grafts, catheters, extracorporeal perfusion circuits) to improve biocompatibility and reduce bioresponses to blood contact to coated biomaterials as well as to resist and respond to bacterial biofilm formation.

Selected Publications:

Kandel, J., Picard, M., Wallace, D.C., Eckmann: MtDNA 3243A>G heteroplasmy is associated with changes in cytoskeletal protein expression and cell mechanics Journal of the Royal Society Interface 14 : 20170071,2017.

Grady, M.E., Parrish, E., Seeger, S., Caporizzo, M.A., Composto, R.J.*, Eckmann: Intracellular nanoparticle dynamics affected by cytoskeletal integrity Soft Matter 13 : 1873-1880,2017.

Grady, M.E., Composto, R.J., Eckmann: Cell elasticity with altered cytoskeletal architectures across multiple cell types Journal of Mechanical Behavior of Biomedical Material 61 : 197-207,2016.

Kandel, J., Angelin, A.A., Wallace, D.C., Eckmann: Mitochondrial respiration is sensitive to cytoarchitectural breakdown Integrative Biology 8 : 1170-1182,2016.

Kandel, J., Chou, P., Eckmann: Automated detection of whole-cell mitochondrial motility and its dependence on cytoarchitectural integrity Biotechnology & Bioengineering 112 (7): 1395-1405,2015.

Lee, H.S., Dastgheyb, S.S., Hickok, N.J., Eckmann, D.M.,* Composto: Controlled and localized release of Tobramycin from a stimuli-responsive grafted bilayer challenged with S. aureus Biomacromolecules 16 (2): 650-659,2015.

Coll Ferrer, M.C., Zern, B., Composto, R.J., Muzykantov, V.R., Eckmann: ICAM-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation PLoS ONE 9 (7): e102329,2014.

Kandel, J., Lee, H.S., Sobolewski, P., Tomczyk, N., Composto, R.J., Eckmann: Chemically grafted fibronectin for use in QCM-D cell studies Biosensors and Bioelectronics 58 : 249-257,2014.

Lee, H.S., Stachelek, S.J., Tomczyk, N., Composto, R.J., Eckmann: Correlating macrophage morphology and cytokine production resulting from biomaterial contact Journal of Biomedical Materials Research Part A 101 (1): 203-212,2013.

Coll Ferrer, M.C., Hickok, N.J., Eckmann, D.M., Composto: Antibacterial biomimetic hybrid films Soft Matter 8 : 2423-2431,2012.

View all publications

Academic Contact Info

331 John Morgan Building/6112
3620 Hamilton Walk

Philadelphia, PA 19104-6802
Phone: (215) 349-5348

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