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David M. Eckmann, MD

David M. Eckmann, MD Physician

Horatio C. Wood Professor of Anesthesiology and Critical Care

Dr. Eckmann is a Penn Medicine employed physician.

Clinical Specialties


  • Anesthesiology and Critical Care

Programs & Centers:

Board Certification:

  • Anesthesiology, 1997

Description of Clinical Expertise

Anesthesiology, airway management, regional anesthesia, bariatrics, obesity

Practice Locations and Appointments

  • Anesthesia

    Hospital of the University of Pennsylvania 6 Dulles 3400 Spruce Street Philadelphia, PA 19104

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Northwestern University Feinberg School of Medicine
Residency: The Evanston Hospital
Residency: Northwestern Medical Center


American Society of Anesthesiologists, International Association of University Anesthesiologists, National Biomedical Engineering Society, International Committee on Credible Practice of Modeling & Simulation in Healthcare; Interagency Modeling and Analysis Group/Multiscale Modeling Consortium, National Deutsche Forschungsgemeinschaft (German Research Foundation), International IMAG/MSM Consortium Clinical and Translational Issues Working Group, National Interagency Modeling and Analysis Group (NIH/NSF/DOE/NASA/DOD/USDA/FDA), National International Anesthesia Research Society, International John Morgan Society (University of Pennsylvania), Local Natural Sciences and Engineering Research Council of Canada (NSERC), International Pennsylvania Society of Anesthesiologists, Local Philadelphia Pediatric Medical Device Consortium, Local US-Israel Binational Science Foundation, International

Hospital Affiliation

Dr. Eckmann is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My current cardiovascular research interests fall into 3 areas:

1. Cellular metabolic engineering. We are examining the relationship between cellular metabolic function and cellular mechanical function. Our goal is to understand mitochondrial function and cellular bioenergetics in the face of cellular mechanical dysfunction and to understand maintenance of cellular mechanical homeostasis when cellular metabolic capacity becomes stressed.

2. Optimization of nanocarrier design for targeted vascular drug delivery. We are using a combination of experimental and computational techniques to assess the influence of design parameters (e.g., carrier type, size, shape, surface density of targeting binding molecules) to optimize carrier binding to vascular endothelium for targeted drug delivery.

3. Biomimetic macromolecular surface grafting for biocompatibility and anti-infectivity of vascular biomaterials. We are making biomimetic surface molecular constructs of biomacromolecules having bioresponsive swelling properties for drug elution. These thin film layers can be grafted onto solid substrates (e.g., vascular stents, grafts, catheters, extracorporeal perfusion circuits) to improve biocompatibility and reduce bioresponses to blood contact to coated biomaterials as well as to resist and respond to bacterial biofilm formation.

Selected Publications:

Kandel, J., Chou, P., Eckmann, D.M.: Automated detection of whole-cell mitochondrial motility and its dependence on cytoarchitectural integrity Biotechnology & Bioengineering 112 (7): 1395-1405,2015.

Lee, H.S., Dastgheyb, S.S., Hickok, N.J., Eckmann, D.M.,* Composto, R.J.*: Controlled and localized release of Tobramycin from a stimuli-responsive grafted bilayer challenged with S. aureus Biomacromolecules 16 (2): 650-659,2015.

Coll Ferrer, M.C., Zern, B., Composto, R.J., Muzykantov, V.R., Eckmann, D.M.: ICAM-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation PLoS ONE 9 (7): e102329,2014.

Kandel, J., Lee, H.S., Sobolewski, P., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Chemically grafted fibronectin for use in QCM-D cell studies Biosensors and Bioelectronics 58 : 249-257,2014.

Lee, H.S., Stachelek, S.J., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Correlating macrophage morphology and cytokine production resulting from biomaterial contact Journal of Biomedical Materials Research Part A 101 (1): 203-212,2013.

Coll Ferrer, M.C., Hickok, N.J., Eckmann, D.M., Composto, R.J.: Antibacterial biomimetic hybrid films Soft Matter 8 : 2423-2431,2012.

Calderon, A.J., Bhowmick, T., Leferovich, J., Burman, B., Pichette, B., Muzykantov, V.N., Eckmann, D.M.*, Muro, S.*: Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers Journal of Controlled Release 150 : 37-44,2011.

Sobolewski, P., Kandel, J., Klinger, A.L., Eckmann, D.M.: Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores American Journal of Physiology - Cell Physiology 301 (3): C679-C686,2011.

Stachelek, S.J., Finley, M.J., Alferiev, I., Wang, F., Tsai, R., Eckells, E.C., Tomczyk, N., Connolly, J.M., Discher, D.E., Eckmann, D.M., Levy, R.J.: The effect of CD 47 modified polymer surfaces on inflammatory cell attachment and activation Biomaterials 32 : 4317-4326,2011.

Liu, J., Weller, G.E.R., Zern, B., Ayyaswamy, P.S., Eckmann, D.M., Muzykantov, V., Radhakrishnan, R.: A computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and Atomic Force Microscopy experiments Proceedings of the National Academy of Sciences 107 (38): 16530-16535,2010.

View all publications

Academic Contact Info

331 John Morgan Building/6112
3620 Hamilton Walk

Philadelphia, PA 19104-6802
Phone: (215) 349-5348
Fax: (215) 349-5078

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