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Daniel N. Holena, MD

Daniel N. Holena, MD Physician

Associate Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia Associate Professor of Epidemiology in Biostatistics and Epidemiology

Dr. Holena is employed by Penn Medicine.

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Clinical Specialties


  • Trauma Surgery

Programs & Centers:

Board Certification:

  • Surgery, 2007
  • Surgical Critical Care, 2008

Clinical Expertise:

  • Emergency General Surgery
  • Emergency Trauma
  • Surgical Critical Care

Description of Clinical Expertise

Dr. Daniel Holena is board certified in General Surgery and Surgical Critical Care. He received his General Surgery training at Cornell, and completed is fellowship in Trauma Surgery and Surgical Critical Care at the University of Pennsylvania. Dr. Holena specializes in the treatment of traumatic injury, emergency general surgery conditions, and surgical critical care. His research interests include outcomes after emergency general surgery and triage biomarkers in acute trauma.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: State University of New York at Stony Brook
Residency: NewYork-Presbyterian/Columbia University Medical Center
Fellowship: Hospital of the University of Pennsylvania


American Association for the Surgery of Trauma, National American College of Surgeons, National American College of Surgeons, Philadelphia Chapter, National American Medical Association, National Association for Academic Surgery, National Eastern Association for the Surgery of Trauma, National European Society for Trauma & Emergency Surgery, International Pennsylvania Medical Society, Local Pennsylvania Trauma Systems Foundation, Local Society for Advancement of Violence and Injury Research, National Society of Critical Care Medicine, National Society of University Surgeons, National

Hospital Affiliation

Dr. Holena is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Holena's research interests encompass the study of quality of care after injury. He has a specific interest in the methodology used for risk-adjusting trauma morbidity, mortality, and failure to rescue.

Selected Publications:

Dumas RP, Seamon MJ, Smith BP, Yang W, Cannon JC, Schwab CW, Reilly PM, Holena DN: The epidemiology of emergency department thoracotomy in a statewide trauma system: Does center volume matter? Journal of Trauma : 2018 (Epub).

Marcaccio C, Dumas RP, Huang Y, Wang GJ, Holena DN: Delayed endovascular aortic repair is associated with reduced in-hospital mortality in patients with blunt thoracic aortic injury Journal of Vascular Surgery : 2018 .

Chreiman KM, Dumas RP, Seamon MJ, Kim PK, Reilly PM, Kaplan LJ, Christie JD, Holena DN: The IOs have it: A prospective observational study of vascular access success rates in patients in extremis using video review Journal of Trauma & Acute Care Surgery : 2018 .

Sangal R, Holena D: Man in motor vehicle collision Journal of Emergency Medicine : 2018 .

Holena,DN: Outcomes of Emergency General Surgery in Patients with Solid organ and Liquid Cancers. e-Poster presentation in Scientific Forum program at the American College of Surgeons. Boston, Oct 21-25 2018. : 2018.

Sara F. Jacoby, Elinore J. Kaufman, Therese S. Richmond, Daniel N. Holena: When Healthcare and Law Enforcement Intersect in Trauma Care, What Rules Apply? Health Affairs Blog, : 2018.

Kaufman E, Earl-Royal E, Barie P, Holena DN.: “Failure to Rescue after Infectious Complications in a Statewide Trauma System”. Poster Presentation, AAST Sept 26-29 2018 in San Diego, CA. : 2018.

Acker Andrew; Leonard Jennifer; Seamon Mark J; Holena Daniel N; Pascual Jose; Smith Brian P; Reilly Patrick M; Martin Niels D: Leaving contaminated trauma laparotomy wounds open reduces wound infections but does not add value Journal of surgical research 232 : 450-455,2018.

Zebrowski A, Carr B, Karp D, Hsu J, Holena D. (missing authors): Factors Relating to Receiving High Intensity Care in Older Adults with Blunt Traumatic Injury. Poster Presentation. Annual Research Meeting Academy Health, Seattle, Washington June 25, 2018. : 2018.

Holena DN, Dumas RP, Kaufman EJ, Huang Y, Wiebe DJ, Reilly PM, Christie JD: Cardiac complications and failure to rescue after injury in a mature statewide trauma system: Identifying opportunities for improvement ESTES 2018, Valencia, Spain : 2018.

Academic Contact Info

Division of Trauma, Surgical Critical Care & Emergency Surgery
Penn Presbyterian Medical Center
51 North 39th St., Suite 120

Philadelphia , PA 19104
Phone: (215) 662-7323
Patient appointments: 800-789-7366 (PENN)

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