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Daniel N. Holena, MD

Daniel N. Holena, MD Surgeon

Assistant Professor of Epidemiology in Biostatistics and Epidemiology Assistant Professor of Surgery at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia

Dr. Holena is employed by Penn Medicine.

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Clinical Specialties


  • Traumatology, Surgical Critical Care and Emergency Surgery

Programs & Centers:

Board Certification:

  • Surgery, 2007
  • Surgical Critical Care, 2008

Clinical Expertise:

  • Emergency General Surgery
  • Emergency Trauma
  • Surgical Critical Care

Description of Clinical Expertise

Dr. Daniel Holena is board certified in General Surgery and Surgical Critical Care. He received his General Surgery training at Cornell, and completed is fellowship in Trauma Surgery and Surgical Critical Care at the University of Pennsylvania. Dr. Holena specializes in the treatment of traumatic injury, emergency general surgery conditions, and surgical critical care. His research interests include outcomes after emergency general surgery and triage biomarkers in acute trauma.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: State University of New York at Stony Brook
Residency: NewYork-Presbyterian/Columbia University Medical Center
Fellowship: Hospital of the University of Pennsylvania


American Association for the Surgery of Trauma, National American College of Surgeons, National American Medical Association, National Association for Academic Surgery, National Eastern Association for the Surgery of Trauma , National European Society for Trauma & Emergency Surgery, International Pennsylvania Medical Society, Local Society for Advancement of Violence and Injury Research, National Society of Critical Care Medicine, National Society of University Surgeons, National

Hospital Affiliation

Dr. Holena is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Holena's research interests encompass the study of quality of care after injury. He has a specific interest in the methodology used for risk-adjusting trauma morbidity, mortality, and failure to rescue.

Selected Publications:

Sharoky CE, Martin ND, Smith BP, Pascual JL, Kaplan LJ, Reilly PM: Failure to Rescue Rates Across a Statewide Trauma System. 13th Annual Academic Surgical Congress. Jacksonville, FL : 2018.

Holena DN, Dumas RP, Seamon MJ, Smith BP, Yang W, Cannon JW, Schwab CW: The Epidemiology of Resuscitative Thoracotomy: Does Center Volume Matter? Poster Presentation. Academic Surgical Congress. Jacksonville, FL : 2018.

Medford-Davis LN, Holena DN, Karp D, Kallan MJ: Which transfers can we avoid: Multi-state analysis of factors associated with discharge home without procedure after ED to ED transfer for traumatic injury American Journal of Emergency Medicine : 2017 (Epub).

Nunn AM, Pascual JL, Hatchimonji J, Reilly PM, Seamon MJ, Holena DN, Smith BP, Kaplan L, Martin ND: Boarding ICU patients: Are our rounding practices subpar? American Journal of Surgery : 2017 (Epub).

Kaufman EJ, Jacoby SF, Carr BG, Sharoky CE, Delgado, MK, Reilly PM: Patient characteristics and temporal trends in police transport of blunt trauma patients: A multicenter retrospective cohort study Prehospital & Emergency Care : 1-7,2017 (Epub).

Kaufman EJ, Jacoby SF: A safe haven for the injured? Urban trauma care at the intersection of healthcare, law enforcement, and race Social Science & Medicine : 2017 (Epub).

Resnick S, Seamon MJ, Holena D, Pascual J, Reilly PM: Early declaration of death by neurologic criteria results in greater organ donor potential Journal of Surgical Research 218 : 29-34,2017.

Marcaccio C, Dumas RP, Huang Y, Wang GJ: Delayed Endovascular Aortic Repair is Associated with Reduced In-Hospital Mortality in Patients with Blunt Thoracic Aortic Injury. Journal of Vascular Surgery : 2017.

Holena DN, Kauffman EJ, Delgado MK, Carr BG, Wiebe DJ, Christie JD: A metric of our own: Failure to rescue after trauma Journal of Trauma & Acute Care Surgery 83 (4): 698-704,2017.

Mackay EM, Dutton R, Holena DN, Reilly PM, Seamon MJ, Smith BP, Kaplan L: Abnormal calcium levels during trauma resuscitation are associated with increased mortality, increased blood products use, and greater hospital resource consumption: A pilot investigation Anesthesia & Analgesia 125 (3): 895-901,2017.

Academic Contact Info

Division of Trauma, Surgical Critical Care & Emergency Surgery
Penn Presbyterian Medical Center
51 North 39th St., Suite 120

Philadelphia, PA 19104
Phone: (215) 662-7323
Patient appointments: 800-789-7366 (PENN)

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