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Caryn Lerman, PhD

Caryn Lerman, PhD Researcher

John H. Glick, M.D. Professor in Cancer Research

Dr. Lerman is employed by Penn Medicine.

Clinical Specialties

Specialty:

  • Psychiatry

Programs & Centers:

Description of Clinical Expertise

Licensed clinical psychologist

Memberships

AACR Behavioral Science Task Force: Chair, National Academy of Behavioral Medicine Research, American Association for Cancer Research, American College of Neuropsychopharmacology, International American College of Neuropsychopharmacology, National American Psychological Association, American Society of Human Genetics: Member of international committee to establish guidelines for genetic testing for BRCA1, National Association for Advancement of Behavior Therapy: Coordinator of Professional Seminars, National California Tobacco-Related Disease Research Group: Member of Sociobehavioral Study Section, National Cancer Research Campaign (United Kingdom): Ad hoc grant reviewer for behavioral research, London, England, National Center for Human Genome Research: Member of ad hoc study section: Ethical, Legal, and Social Implications of Human Genome Research, National College of Problems on Drug Dependence, National Conference Co-Chair: AACR International Conference: "Molecular Pathogenesis of Lung Cancer: Translation to the Clinic", International Department of Health and Human Services/Office on Women's Health: Member of National Action Plan on Breast Cancer, Susceptibility Gene Working Group, National Duke University Comprehensive Cancer Center, External Advisory Board for Cancer Prevention Research Unit, National Dutch Cancer Society: Ad hoc grant reviewer, National Eastern Cooperative Oncology Group: Chairperson of Behavioral Science Committee, National Executive Scientific Committee: AACR Prevention Conference , National External Advisory Board, Indiana University, Indiana Institute for Personalized Medicine, National External Advisory Board, MD Anderson Cancer Center, National External Advisory Board, UC Irvine, Chao Family Comprehensive Cancer Center , National External Advisory Board, USC, Norris Cancer Center, National Institute of Medicine: Member of Committee on Behavioral, Social, and Genetic Factors in Health , National International Workshop: Chairperson of Advisory Committee for “Critical Choices: The Social, Behavioral, Ethical and Legal Implications of Genetic Testing for Heritable Breast/Ovarian and Colon Cancer Risks,” Toronto, Ontario, Canada, National Israel Cancer Association: Ad hoc grant reviewer, International Mayo Clinic Cancer Center, External Scientific Advisory Board, National Medical Research Counsel (United Kingdom): Ad hoc grant reviewer for cancer genetics applications, National Memorial Sloan Kettering Cancer Center, Board of Scientific Counselors, National National Academy of Medicine (formerly Institute of Medicine), National National Cancer Institute (Canada): Member of Cancer Control/Behavioral Research Advisory Panel, Ontario, Canada, International National Cancer Institute: Scientific Review Committee member for the following RFAs: Interdisciplinary Studies in Genetic Epidemiology of Cancer, (DCE); Psychosocial Effects of DES Exposure, (DCPC); Rehabilitation and Psychosocial Research in Younger Women with Breast Cancer , National National Cancer Institute: Member of ad hoc Scientific Review Committee for RFA on Cancer and the Family, National National Cancer Institute: Member of review committee and site visitor for Program Project and Cancer Center Core Grant applications, National National Cancer Institute: Member of Scientific Review Committee and Site Visitor for Cancer Center Core Grant application, National National Cancer Institute: Member of Scientific Review Committee and Site Visitor for Program Project and Cancer Center Core Grant applications, National National Cancer Institute: Member of Scientific Review Committee and Site Visitor for Program Project and Cancer Center Core Grant Applications, National National Cancer Institute: Member of Scientific Review Committee for RFA on Biobehavioral Basis of Cancer Risk Behaviors, National National Center for Human Genome Research (NCHGR): Member of Cancer Studies Consortium for Research on Genetic Testing for Cancer Susceptibility, National National Center for Human Genome Research: Chairperson of ad hoc study section: Ethical, Legal and Social Implications of Human Genome Research, National National Institute of Drug Abuse: Member, Science of Genetics Workgroup, National National Institute of Drug Abuse: Workgroup Chair, Adoption of NIDA’s Evidence Based Treatments in Real World Settings , National National Institute of Mental Health: Member of advisory committee for “NIMH Priorities in Health and Behavior Research”, National National Institute on Drug Abuse: Ad Hoc Reviewer for Social Neuroscience of Addiction Research, National National Institutes of Health (NIH)/National Cancer Institute: Participant in Workshop to Establish Priorities for Behavioral Research in Cancer, National National Institutes of Health/Division of Research Grants: Member of Behavioral Medicine Study Section (resigned in 1996 to accept appointment to NCI Board of Scientific Advisors; continued study section participation on an ad hoc basis), National National Institutes of Health: Ad Hoc Reviewer for Risk Prevention and Health Behavior Study Section, National NCHGR/Johns Hopkins: Member of external advisory committee for Genetic Counseling graduate program, National NIH/National Cancer Institute Lung Cancer Implementation Group: Member of NCI Senior Leadership Committee, National NIH/National Cancer Institute: Board of Scientific Advisors, National NIH/National Cancer Institute: Chair and Member, Behavioral Science Working Group for Cancer Genetics Network , National NIH/National Cancer Institute: Chairperson, Behavioral Science Advisory Committee , National NIH/National Cancer Institute: Co-chair, Tobacco Research Implementation Group (working group to develop tobacco research plan for NCI) , National NIH/National Cancer Institute: Member of Advisory Group for NCI Genetic Epidemiologic Study of Familial Cancer and the BRCA1 Gene , National NIH/National Cancer Institute: Member of Working Group on Genetic Testing for Cancer Susceptibility , National NIH/National Human Genome Research Institute: ELSI Research, Planning and Evaluation Subcommittee of National Advisory Council , National NIH/National Human Genome Research Institute: Member of Advisory Council, National NIH/National Institute on Drug Abuse: Member of National Advisory Council, National NIH/National Institute on Drug Abuse: Member of Neurochip Working Group, National NIH/Office of Behavioral and Social Science Research: Consultant on Behavioral Science Research Priorities , National Ohio State Cancer Center, External Scientific Advisory Board, National Society for Neuroscience, International Society for Research on Nicotine and Tobacco, International Society of Behavioral Medicine: Member of Program and Membership Committees, National University of Chicago Cancer Center, External Scientific Advisory Board, National University of North Carolina Lineberger Cancer Center, External Scientific Advisory Board, National

Hospital Affiliation

Dr. Lerman is employed by Penn Medicine.

Research

Description of Research Expertise:

Dr. Lerman's work translates research in neuroscience, pharmacology, genetics, and behavioral science to develop improved interventions for health risk behavior change.

Selected Publications:

Falcone M Cao W Bernardo L Tyndale RF Loughead J Lerman C: Brain responses to smoking cues differ based on nicotine metabolism rate. Biological Psychiatry 80 (3): 190-197,2016.

Loughead J, Wileyto EP, Ruparel K, Falcone M, Hopson R, Gur R, Lerman C.: Working memory-related neural activity predicts future smoking relapse. Neuropsychopharmacology 40 (6): 1311-1320,2015.

Lerman C, Schnoll, RA, Hawk LW, Cinciripini P, George TP, Wileyto EP, Swan GE, Benowitz NI, Heitjan DF, Tyndale RF, PGRN-PNAT Research Group.: Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial. The Lancet Respiratory Medicine 3 (2): 131-138,2015.

Lerman C, Gu H, Loughead J, Ruparel K, Yang Y, Stein EA.: Large scale brain network coupling predicts acute nicotine abstinence effects on craving and cognitive function. JAMA Psychiatry 71 (5): 523-530 ,2014.

Mrazek DA, Lerman C. : Pharmacogenomics: facilitating clinical implementation. Journal of the American Medical Association 306 (3): 304-305,2011.

Ray R, Ruparel K, Newberg A, Wileyto EP, Loughead J, Divgi C, Blendy JA, Logan J, Zubieta JK, Lerman C.: Human mu opioid receptor (OPRM1 A118G) polymorphism is associated with brain mu opiod receptor binding potential in smokers. Proceedings of the National Academy of Sciences USA 108 (22): 9268-9273,2011.

Loughead J, Ray R, Wileyto EP, Ruparel K, Sanborn P, Siegel S, Gur RC, Lerman C.: Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers. Biological Psychiatry 67 (8): 715-721,2010.

Schnoll RA, Patterson F, Wileyto EP, Heitjan D, Shields AE, Asch D, Lerman C.: Effectiveness of extended duration transdermal nicotine therapy: a randomized trial. Annals of Internal Medicine 152 (3): 144-151,2010.

Loughead J, Wileyto EP, Valdez NJ, Sanborn P, Tang K, Strasser AA, Ruparel K, Ray R, Gur RC, Lerman C.: Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype. Molecular Psychiatry 14 (8): 820-826,2009.

Academic Contact Info

Center for Interdisciplinary Research on Nicotine Addiction (CIRNA)
3535 Market Street, Suite 4100

Philadelphia, PA 19104
Phone: 215-746-7141
Fax: 215-746-7140