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Caryn Lerman, PhD

Caryn Lerman, PhD Researcher

John H. Glick, M.D. Professor in Cancer Research

Dr. Lerman is a Penn Medicine employed physician.

Clinical Specialties


  • Psychiatry

Programs & Centers:

Description of Clinical Expertise

Licensed clinical psychologist


Academy of Behavioral Medicine Research, American Association for Cancer Research, American College of Neuropsychopharmacology, International American College of Neuropsychopharmacology, National American Psychological Association, External Advisory Board, Indiana University, Indiana Institute for Personalized Medicine, National External Advisory Board, MD Anderson Cancer Center, National External Advisory Board, UC Irvine, Chao Family Comprehensive Cancer Center, National External Advisory Board, USC, Norris Cancer Center, National Memorial Sloan Kettering Cancer Center, Board of Scientific Counselors, National National Academy of Medicine (formerly Institute of Medicine), National Society for Neuroscience, International Society for Research on Nicotine and Tobacco, International University of North Carolina Lineberger Cancer Center, External Scientific Advisory Board, National

Hospital Affiliation

Dr. Lerman is a Penn Medicine employed physician.


Description of Research Expertise:

Dr. Lerman's work translates research in neuroscience, pharmacology, genetics, and behavioral science to develop improved interventions for health risk behavior change.

Selected Publications:

Falcone M Cao W Bernardo L Tyndale RF Loughead J Lerman C: Brain responses to smoking cues differ based on nicotine metabolism rate. Biological Psychiatry 80 (3): 190-197,2016.

Loughead J, Wileyto EP, Ruparel K, Falcone M, Hopson R, Gur R, Lerman C.: Working memory-related neural activity predicts future smoking relapse. Neuropsychopharmacology 40 (6): 1311-1320,2015.

Lerman C, Schnoll, RA, Hawk LW, Cinciripini P, George TP, Wileyto EP, Swan GE, Benowitz NI, Heitjan DF, Tyndale RF, PGRN-PNAT Research Group.: Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial. The Lancet Respiratory Medicine 3 (2): 131-138,2015.

Lerman C, Gu H, Loughead J, Ruparel K, Yang Y, Stein EA.: Large scale brain network coupling predicts acute nicotine abstinence effects on craving and cognitive function. JAMA Psychiatry 71 (5): 523-530,2014.

Mrazek DA, Lerman C.: Pharmacogenomics: facilitating clinical implementation. Journal of the American Medical Association 306 (3): 304-305,2011.

Ray R, Ruparel K, Newberg A, Wileyto EP, Loughead J, Divgi C, Blendy JA, Logan J, Zubieta JK, Lerman C.: Human mu opioid receptor (OPRM1 A118G) polymorphism is associated with brain mu opiod receptor binding potential in smokers. Proceedings of the National Academy of Sciences USA 108 (22): 9268-9273,2011.

Loughead J, Ray R, Wileyto EP, Ruparel K, Sanborn P, Siegel S, Gur RC, Lerman C.: Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers. Biological Psychiatry 67 (8): 715-721,2010.

Schnoll RA, Patterson F, Wileyto EP, Heitjan D, Shields AE, Asch D, Lerman C.: Effectiveness of extended duration transdermal nicotine therapy: a randomized trial. Annals of Internal Medicine 152 (3): 144-151,2010.

Loughead J, Wileyto EP, Valdez NJ, Sanborn P, Tang K, Strasser AA, Ruparel K, Ray R, Gur RC, Lerman C.: Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype. Molecular Psychiatry 14 (8): 820-826,2009.

Academic Contact Info

Center for Interdisciplinary Research on Nicotine Addiction (CIRNA)
3535 Market Street, Suite 4100

Philadelphia, PA 19104
Phone: (215) 746-7141
Fax: (215) 746-7140