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Bruce L. Levine, PhD

Bruce L. Levine, PhD Researcher

Barbara and Edward Netter Professor in Cancer Gene Therapy

Dr. Levine is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Practice Locations and Appointments

Memberships

Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, National Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, National Abstract reviewer for American Society for Gene Therapy Annual Meeting, National Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, International Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, International Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, International Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, International Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, International Abstract reviewer for International Society for Cellular Therapy Annual Meeting, International American Association for the Advancement of Science, National American Society for Gene and Cell Therapy, National American Society of Gene Therapy, National Cambridge Healthtech Institute, National Cancer Prevention and Research Institute of Texas: Texas Access to Cancer Cell Therapies (TACCT), National Coordinating Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, National International Society for Cellular Therapy, International NIH Study Section, Immunology Integrated Review Group SSS-4 SBIR/STTR, National NIH/NHLBI Program: Production Assistance for Cellular Therapies, National NIH/NIAID Clinical Trial Planning (R34) Grants Study Section, National NIH/NIAID Study Section, Center for AIDS Research: D-CFAR, CFAR, National NIH/NIAID Study Section, Center for AIDS Research: D-CFAR, CFAR, National

Hospital Affiliation

Dr. Levine is employed by Penn Medicine.

Research

Description of Research Expertise:

Immunology, Cell and Gene Therapy

Selected Publications:

Mueller Karen T, Waldron Edward R, Grupp Stephan A, Levine John E, Laetsch Theodore W, Pulsipher Michael A, Boyer Michael W, August Keith, Hamilton Jason, Awasthi Rakesh, Stein Andrew M, Sickert Denise, Chakraborty Abhijit, Levine Bruce L, June Carl H, Tomassian Lori, Shah Sweta, Leung Mimi, Taran Tetiana, Wood Patricia A, Maude Shannon L: Clinical Pharmacology of Tisagenlecleucel in B-Cell Acute Lymphoblastic Leukemia. Clinical Cancer Research : 2018.

Ghassemi S, Nunez-Cruz S, O'Connor RS, Fraietta JA, Patel PR, Scholler J, Barrett DM, Lundh SM, Davis MM, Bedoya F, Leferovich J, Lacey SF, Levine BL, Grupp SA, June CH, Melenhorst JJ, Milone MC: Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells Cancer Immunol Res. : 2018.

Svoboda J, Rheingold SR, Gill SI, Grupp SA, Lacey SF, Kulikovskaya I, Suhoski MM, Melenhorst JJ, Loudon B, Mato AR, Nasta SD, Landsburg DJ, Youngman MR, Levine BL, Porter DL, June CH, Schuster SJ: Non-viral RNA chimeric antigen receptor modified T cells in patients with Hodgkin lymphoma Blood : 2018.

Fraietta JA1, Nobles CL, Sammons MA, Lundh S, Carty SA, Reich TJ, Cogdill AP, Morrissette JJD, DeNizio JE, Reddy S, Hwang Y, Gohil M, Kulikovskaya I, Nazimuddin F, Gupta M, Chen F, Everett JK, Alexander KA, Lin-Shiao E, Gee MH, Liu X, Young RM, Ambrose D, Wang Y, Xu J, Jordan MS, Marcucci KT, Levine BL, Garcia KC, Zhao Y, Kalos M, Porter DL, Kohli RM, Lacey SF, Berger SL, Bushman FD, June CH, Melenhorst JJ: Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells Nature : 2018.

Fraietta Joseph A, Lacey Simon F, Orlando Elena J, Pruteanu-Malinici Iulian, Gohil Mercy, Lundh Stefan, Boesteanu Alina C, Wang Yan, O'Connor Roddy S, Hwang Wei-Ting, Pequignot Edward, Ambrose David E, Zhang Changfeng, Wilcox Nicholas, Bedoya Felipe, Dorfmeier Corin, Chen Fang, Tian Lifeng, Parakandi Harit, Gupta Minnal, Young Regina M, Johnson F Brad, Kulikovskaya Irina, Liu Li, Xu Jun, Kassim Sadik H, Davis Megan M, Levine Bruce L, Frey Noelle V, Siegel Donald L, Huang Alexander C, Wherry E John: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature medicine 24 (5): 563-571,2018.

Tanyi Janos L, Bobisse Sara, Ophir Eran, Tuyaerts Sandra, Roberti Annalisa, Genolet Raphael, Baumgartner Petra, Stevenson Brian J, Iseli Christian, Dangaj Denarda, Czerniecki Brian, Semilietof Aikaterini, Racle Julien, Michel Alexandra, Xenarios Ioannis, Chiang Cheryl, Monos Dimitri S, Torigian Drew A, Nisenbaum Harvey L, Michielin Olivier, June Carl H, Levine Bruce L, Powell Daniel J, Gfeller David, Mick Rosemarie, Dafni Urania, Zoete Vincent, Harari Alexandre, Coukos George, Kandalaft Lana E: Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer. Science translational medicine 10 (436): 2018.

Garfall Alfred L, Stadtmauer Edward A, Hwang Wei-Ting, Lacey Simon F, Melenhorst Jan Joseph, Krevvata Maria, Carroll Martin P, Matsui William H, Wang Qiuju, Dhodapkar Madhav V, Dhodapkar Kavita, Das Rituparna, Vogl Dan T, Weiss Brendan M, Cohen Adam D, Mangan Patricia A, Ayers Emily C, Nunez-Cruz Selene, Kulikovskaya Irina, Davis Megan M, Lamontagne Anne, Dengel Karen, Kerr Naseem Ds, Young Regina M, Siegel Donald L, Levine Bruce L, Milone Michael C, Maus Marcela V, June Carl H: Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma. JCI insight 3 (8): 2018.

Beatty Gregory L, O'Hara Mark H, Lacey Simon F, Torigian Drew A, Nazimuddin Farzana, Chen Fang, Kulikovskaya Irina M, Soulen Michael C, McGarvey Maureen, Nelson Anne Marie, Gladney Whitney L, Levine Bruce L, Melenhorst J Joseph, Plesa Gabriela, June Carl H: Activity of Mesothelin-specific Chimeric Antigen Receptor T cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial. Gastroenterology : 2018.

Maude Shannon L, Laetsch Theodore W, Buechner Jochen, Rives Susana, Boyer Michael, Bittencourt Henrique, Bader Peter, Verneris Michael R, Stefanski Heather E, Myers Gary D, Qayed Muna, De Moerloose Barbara, Hiramatsu Hidefumi, Schlis Krysta, Davis Kara L, Martin Paul L, Nemecek Eneida R, Yanik Gregory A, Peters Christina, Baruchel Andre, Boissel Nicolas, Mechinaud Francoise, Balduzzi Adriana, Krueger Joerg, June Carl H, Levine Bruce L, Wood Patricia, Taran Tetiana, Leung Mimi, Mueller Karen T, Zhang Yiyun: Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. The New England journal of medicine 378 (5): 439-448,2018.

Schuster Stephen J, Svoboda Jakub, Chong Elise A, Nasta Sunita D, Mato Anthony R, Anak Özlem, Brogdon Jennifer L, Pruteanu-Malinici Iulian, Bhoj Vijay, Landsburg Daniel, Wasik Mariusz, Levine Bruce L, Lacey Simon F, Melenhorst Jan J, Porter David L, June Carl H: Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas. The New England journal of medicine 377 (26): 2545-2554,2017.

Academic Contact Info

Center for Cellular Immunotherapies
Smilow 8-114
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 746-1481
Patient appointments: 800-789-7366 (PENN)