Find a Doctor or Practice Location

Are you a referring physician?
within
I am searching for a
Reset Form
Ben Stanger, MD, PhD

Ben Stanger, MD, PhD Physician

Professor of Medicine Associate Professor of Cell and Developmental Biology

Dr. Stanger is employed by Penn Medicine.

Request a Callback
No Patient Satisfaction Reviews
Why not?

There is no publicly available rating for this medical professional for one of the following reasons:

  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients.
  3. He or she sees patients but has not yet received the minimum 30 patient satisfaction reviews in the past 12 months, ensuring that the rating is statistically reliable and a true reflection of patient satisfaction.
X

Clinical Specialties

Specialty:

  • Gastroenterology

Programs & Centers:

  • Endoscopy and GI Diagnosis Services

Board Certification:

  • Gastroenterology, 2003

Clinical Expertise:

  • Anal Cancer
  • Bile Duct Cancer (Cholangiocarcinoma)
  • Colon Cancer
  • Endoscopy
  • Esophageal Cancer
  • Gallbladder Cancer
  • Gastrointestinal Carcinoid Tumor
  • Liver Cancer
  • Neuroendocrine Tumors
  • Pancreatic Cancer
  • Rectal Cancer
  • Small Intestine Cancer
  • Stomach Cancer (Gastric Cancer)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Harvard Medical School
Residency: UCSF Medical Center and Hospital
Fellowship: Massachusetts General Hospital

Memberships

American Association for Cancer Research, National American Association for the Study of Liver Diseases, National Beta Cell Biology Consortium (NIH/NIDDK) grant review panel, NIH/NIDDK Special Emphasis Panels (R24), Developmental Therapeutics (DT) Study Section (R01), Tumor Progression and Metastasis (TPM) Study Section (R01), NIH/NIDDK Special Emphasis Panel (UC4), Tissue Chips Review Panel (UG3/UH3), Bethesda, MD and Rockville, MD, National Israel Cancer Research Fund (ICRF), International The Cholangiocarcinoma Foundation, National

Hospital Affiliation

Dr. Stanger is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Radnor: Has privileges to perform procedures.
  • Penn Presbyterian Medical Center: On the medical staff, but does not have privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Research Interests

Cell Plasticity
Pancreatic Cancer
Tumor Immunology
Liver Regeneration

Key words: Metastasis, Pancreatic Cancer, Tumor Immunology, Cell Plasticity

Description of Research
Cell Plasticity in Regeneration and Cancer
During development, cells acquire specialized features through a series of differentiation events. Under normal circumstances, adult cells retain their differentiated identities. However, under a variety of experimental and physiological situations, cell identity can shift. This adult cell plasticity can involve an interchange between adult cellular identities (termed "trans-differentiation") or a reversion from a specialized state to a progenitor stated (termed "de-differentiation"). Our laboratory uses genetically engineered mice to understand how cell identity is maintained in vivo. We study cellular plasticity in the context of liver regeneration, diabetes, and cancer - where epithelial-to-mesenchymal transition promotes cell invasion and metastasis. In addition, we have a strong interest in tumor immunology, and the mechanisms by which tumor cells influence their microenvironment. We believe that the ability to manipulate cellular identity in these settings will facilitate the development of novel therapies for cancer and degenerative disease.


Rotation Projects
Rotation projects may be available based upon applicant interest. Please contact Dr. Stanger directly to discuss potential projects.

Lab personnel:
Ben Stanger, MD, PhD - Principal Instigator
Chenghua Yang - Research Specialist, Lab Manager
Ravi Maddipatti, MD - Research Associate
Takeshi Katsuda, PhD – Postdoctoral Fellow
Allyson J. Merrell, PhD - Postdoctoral Fellow
Taiji Yamazoe, PhD - Postdoctoral Fellow
Yogev Sela, PhD - Postdoctoral Researcher
Jinyang Li - Graduate Student
Bobby Norgard - Graduate Student
Salina Yuan - Graduate Student
Benjamin Kahn – Student Researcher


Administrative Assistant:
Laura Murillo
215-573-0908
murillo@upenn.edu

Selected Publications:

Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ: EMT subtype influences epithelial plasticity and mode of cell migration Developmental Cell 45 (6): 681-695,2018.

Li J, Byrne KT, Yan F, Yamazoe T, Chen Z, Baslan T, Richman LP, Lin J, Sun YH, Rech AJ, Balli D, Hay CA, Sela Y, Merrell AJ, Liudahl SM, Gordon N, Norgard RJ, Yuan S, Yu S, Chao T, Ye S, Eisinger-Mathason TSK, Faryabi RB, Tobias JW, Lowe S, Coussens LM, Wherry EJ, Vonderheide RH, Stanger BZ: Tumor cell-intrinsic factors underlie immune heterogeneity and therapeutic response Immunity 49 (1): 178-193,2018.

Aiello NM, Brabletz T, Kang Y, Nieto MA, Weinberg RA, Stanger BZ: Upholding a role for EMT in pancreatic cancer metastasis Nature 547 (7661): E7-E8,2017.

Merrell AJ, Stanger BZ: Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style Nat Rev Mol Cell Biol 17 (7): 413-25,2016.

Yanger K, Knigin D, Zong Y, Maggs L, Gu G, Akiyama H, Pikarsky E, Stanger BZ: Adult hepatocytes are generated by self-duplication rather than stem-cell differentiation Cell Stem Cell 15 (3): 340-9,2014.

Maddipati R, Stanger BZ: Pancreatic Cancer Metastases Harbor Evidence of Polyclonality Cancer Discov 5 (10): 1086-97,2015.

Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Berrena MG, Fernandez-Zapico ME, Iacobuzzio-Donahue C, Olive KP*, Stanger BZ*: Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma Cancer Cell 25 (6): 735-747,2014.

Rajagopal J, Stanger BZ: Plasticity in the Adult: How Should the Waddington Diagram Be Applied to Regenerating Tissues? Dev Cell 36 (2): 133-7,2016.

View all publications

Academic Contact Info

Abramson Family Cancer Research Institute
Division of Gastroenterology
Department of Medicine
University of Pennsylvania Perelman School of Medicine
512 Biomedical Research Bldg II/III (Office)
527 Biomedical Research Bldg II/III (Lab)
421 Curie Boulevard

Philadelphia, PA 19104
Phone: (215) 746-5560
Patient appointments: 800-789-7366 (PENN)

Related Links