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Barbara K. Schmidt, MD

Barbara K. Schmidt, MD Children's Hospital of Philadelphia Provider

Director of Clinical Research, Neonatology Kristine Sandberg Knisely Professor in Neonatology Professor of Biostatistics and Epidemiology

Dr. Schmidt is employed by the Children's Hospital of Philadelphia.

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About Dr. Barbara K. Schmidt

Recognized by Best Doctors in America 2011-2012

Clinical Specialties


  • Neonatology and Newborn Services

Programs & Centers:

  • Neonatology/Intensive Care Nursery

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Residency: University Hospitals of Freiburg and Surgery
Medical School: Med Fak Der Gerog August University
Residency: University Children's Hospital
Fellowship: The Hospital for Sick Children


American Academy of Pediatrics, National Bronchopulmonary Dysplasia Subcommittee, Primary Prevention of Lung Diseases Workshop, NHLBI, National Canadian Pediatric Society, International Chair, Concurrent Research Subcommittee, Eunice Kennedy Shriver NICHD Neonatal Research Network, NIH, National Data Safety Monitoring Committee (Member) Maternal-Fetal Medicine Units Network, NIH, National Data Safety Monitoring Committee (Member) Trial to Reduce IDDM in the Genetically at Risk (TRIGR), funded by NIH, CIHR and European agencies, National Data Safety Monitoring Committee, Azithromycin to prevent BPD in Ureaplasma-infected preterms, NIH, National Data Safety Monitoring Committee, Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very preterm Infants (MOBYDIck Tria), Canadian Institutes of Health Research, International European Society for Pediatric Research, International Protocol Review Subcommittee, Eunice Kennedy Shriver NICHD Neonatal Research Network, NIH, National

Hospital Affiliation

Dr. Schmidt is employed by the Children's Hospital of Philadelphia.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Barbara Schmidt, MD, MSc, is a Professor of Pediatrics and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania School of Medicine. She is also a staff neonatologist in the Division of Neonatology at the Children’s Hospital of Philadelphia and the University of Pennsylvania Health System.

Dr. Schmidt’s research focuses on collaborative neonatal randomized trials that have clinically important, long-term outcomes such as growth and development. Examples of trials she directed in the past include the “Trial of Indomethacin Prophylaxis in Preterms.” In this study, 1,202 extremely low-birth-weight infants from five countries were followed to the end of the second year of life. The results from the study showed that the high rate of mental and motor deficits in these children is not improved by prophylactic treatment with indomethacin. She is also the principal investigator of the “Caffeine for Apnea of Prematurity” trial, which enrolled over 2,000 very low-birth-weight infants in North America, Europe, Israel and Australia. Caffeine has been used for more than 30 years to regulate the breathing of very preterm babies, but without sufficient knowledge of the possible benefits and risks. To date, this trial has shown that caffeine therapy for apnea of prematurity improves the rate of survival without neurodevelopmental disability up to two years after very preterm birth. This study will continue to follow the study participants well into school age.

Since May 2010, Dr. Schmidt is a Co-Principal Investigator of the Data Coordinating Center for the Prematurity and Respiratory Outcomes Program (PROP) sponsored by NHLBI and located at the University of Pennsylvania School of Medicine. One of the goals of this multi-center collaboration is the identification of predictors of respiratory outcomes that may serve as surrogate endpoints in future trials of prevention and therapy of respiratory diseases in preterm infants. In addition, since April 2011, Dr. Schmidt is the clinical center PI for the University of Pennsylvania and Children’s Hospital of Philadelphia in the reconfigured Neonatal Research Network (NRN) of the Eunice Kennedy Shriver NICHD.

Selected Publications:

Poindexter BB, Feng R, Schmidt B, Aschner JL, Ballard RA, Hamvas A, Reynolds AM, Shaw PA, Jobe AH: Comparisons and Limitations of Current Definitions Bronchopulmonary Dysplasia Ann Am Thorac Soc : 2015.

Schmidt B, Roberts RS, Davis PG, Doyle LW, Asztalos EV, Opie G, Bairam A, Solimano A, Arnon S, Sauve RS: Prediction of Late Death or Disability at Age 5 Years Using a Count of 3 Neonatal Morbidities in Very Low Birth Weight Infants J Pediatr : 2015.

Poets CF, Roberts RS, Schmidt B, Whyte RK, Asztalos EV, Bader D, Bairam A, Moddemann D, Peliowski A, Rabi Y, Solimano A, Nelson H: Association Between Intermittent Hypoxemia or Bradycardia and Late Death or Disability in Extremely Preterm Infants JAMA : 2015.

Synnes A, Anderson PJ, Grunau RE, Dewey D, Moddemann D, Tin W, Davis PG, Doyle LW, Foster G, Khairy M, Nwaesei C, Schmidt B: Predicting severe motor impairment in preterm children at age 5 years Arch Dis Child : 2015.

Foglia E, Nolen T, DeMauro S, Das A, Bell E, Stoll B, Schmidt, B: Short-term Outcomes of Infants Enrolled in Randomized Clinical Trials vs Those Eligible but Not Enrolled JAMA 313 : 2377-2379,2015.

Manley BJ, Roberts RS, Doyle LW, Schmidt B, Anderson PJ, Barrington KJ, Bohm B, Golan A, van Wassenaer-Leemhuis AG, Davis PG1: Social Variables Predict Gains in Cognitive Scores across the Preschool Years in Children with Birth Weights 500 to 1250 Grams. Journal of Pediatrics : 2015.

Costantini L, D'llario J, Moddemann D, Penner K, Schmidt B: Accuracy of Bayley Scores as Outcome Measures in Trials of Neonatal Therapies. JAMA: Pediatrics : 2014.

Marcus CL, Meltzer LJ, Roberts RS, Traylor J, Dix J, D'ilario J, Asztalos E,Opie G, Doyle LW, Biggs SN, Nixon GM, Narang I, Bhattacharjee R, Davey M,Horne RS, Cheshire M, Gibbons J, Costantini L, Bradford R, Schmidt B: For the Caffeine for Apnea of Prematurity - Sleep (CAP-S) study. Long-term Effects of Caffeine Therapy for Apnea of Prematurity on Sleep at School-age. American Journal of Respiratory Critical Care Medicine : 2014.

Schmidt B, Roberts RS, Whyte RK, Asztalos EV, Poets C, Rabi Y, Solimano A, Nelson H: Impact of Study Oximeter Masking Algorithm on Titration of Oxygen Thereapy in the Canadian Oxygen Trial Journal of Pediatrics : 2014.

Marcus CL, Traylor J, Biggs SN, Roberts RS, Nixon GM, Narang I, Bhattacharjee R, Davey MJ, Horne RS, Cheshire M, Gibbons KJ, Dix J, Asztalos E, Doyle LW, Opie GF, D'ilario J, Costantini L, Bradford R, Schmidt B: Feasibility of comprehensive, unattended ambulatory polysomnography in school-aged children Journal of Clinical Sleep Medicine : 2014.

Academic Contact Info

Hospital of the University of Pennsylvania
Division of Neonatology and Newborn Services
3400 Spruce Street, 8 Ravdin

Philadelphia, PA 19104
Phone: (215) 662-3228
Fax: (215) 349-8831
Patient appointments: 800-789-PENN (7366)

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