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Arturo Loaiza-Bonilla, MD

Arturo Loaiza-Bonilla, MD Physician

Assistant Professor of Clinical Medicine

Dr. Loaiza-Bonilla is a Penn Medicine employed physician.

Clinical Specialties

Specialty:

  • Medicine
    • Hematology
    • Medical Oncology

Programs & Centers:

Board Certification:

  • Hematology, 2013
  • Internal Medicine, 2010
  • Medical Oncology, 2013

Clinical Expertise:

  • Ampullary Cancer
  • Gastrointestinal Disorders
  • Liver Cancer
  • Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)

Description of Clinical Expertise

I specialize in clinical and transitional research trials as well as the multidisciplinary, comprehensive care of patients suffering from gastrointestinal malignancies, with particular emphasis in pancreatic, hepatobiliary, colorectal, upper digestive, GIST, adrenal and neuroendocrine cancers (including PNET, pheochromocytoma and paraganglioma).

Using Penn Medicine's state-of-the-art, evidence-based and patient-centered approach, I integrate next-generation personalized molecular diagnostics (CPD testing), immunotherapy, comorbidity, previous therapies and the patient's overall status into decision making for optimal outcomes. I also provide expert second opinions (locally and internationally through Penn Global Medicine), clinical trial guidance, as well as recommendations regarding personalized cancer genomics, and the concomitant use of complementary medicine and integrative oncology measures.

Practice Locations and Appointments

  • Abramson Cancer Center

    Perelman Center for Advanced Medicine West Pavilion, 4th Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Universidad Nacional de Colombia
Residency: Harbor Hospital
Residency: Johns Hopkins Hospital
Fellowship: Jackson Health System - Jackson Memorial
Fellowship: University of Miami Hospital and Clinic

Memberships

AfPA’s National Physicians Biologics Working Group, National American Association for Cancer Research, National American College of Physicians, National American Medical Association - Resident and Fellow Section, National American Medical Association, National American Physician Scientist Association, National American Society for Bone and Marrow Transplantation, National American Society of Clinical Oncology, National American Society of Hematology (ASH) and American Society of Clinical Oncology (ASCO) Hematology and Oncology Carrier Advisory Committee (CAC) Network, National American Society of Hematology, National BioMedExperts, International Colombian Physician Association, International ECOG ACRIN Esophagogastric TF of the Gastrointestinal Steering Committee (GISC), National ECOG-ACRIN - Eastern Cooperative Oncology Group, International Educational Commission on Foreign Medical Graduates - IMG Advisors Network (IAN), National Fundacion Santa Fe Institutional Interns Alumni, International Genomics Pioneers Gateway, International International Society for Pharmacoeconomics and Outcomes Research, International International Society of Gastrointestinal Oncology, International Johns Hopkins Medical Institutions Alumni, National Johns Hopkins Post Doctoral Association (JHPDA), Local ManagingMyeloma.com, International National Hispanic Medical Association, National National Post-Doctoral Association, National North American Neuroendocrine Tumor Society (NANETS), National Pennsylvania Medical Society, Local Pennsylvania Society of Oncology and Hematology, Local ProActive HealthCare USA, International ResearchGate – Scientific Network, International SciLink, International Society of Nuclear Medicine and Molecular Imaging, National Southern Medical Association, Local The Pheochromocytoma and paraganglioma RESearch Support ORganization (PRESSOR), International The Physicians’ Network, International The William J. Harrington Medical Training Programs for Latin America and the Caribbean, International Universidad Nacional de Colombia Alumni, National

Hospital Affiliation

Dr. Loaiza-Bonilla is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Phase I/III trials in gastrointestinal malignancies, with emphasis in new targeted therapies, novel molecules and immunotherapy, tailored to specific tumor type, its genomics and tumor genetic information from the Penn's center of personalized diagnostics. I am principal and co-investigator of multiple studies, including active participation at the Eastern Cooperative Oncology Group (ECOG).

Selected Publications:

Braxton DR, Zhang R, Morrissette JD, Loaiza-Bonilla A, Furth EE: Clinicopathogenomic analysis of mismatch repair proficient colorectal adenocarcinoma uncovers novel prognostic subgroups with differing patterns of genetic evolution Int J Cancer : 2016.

Arturo Loaiza-Bonilla, Christopher E. Jensen, Stuti Shroff, Emma Furth, Paula A. Bonilla-Reyes, Andres F. Deik, Jennifer Morrissette: KDR Mutation as a Novel Predictive Biomarker of Exceptional Response to Regorafenib in Metastatic Colorectal Cancer Cureus 8 (2): e478,2016.

Shawn Peterson, Arturo Loaiza-Bonilla, Edgar Ben-Josef, Jeffrey A. Drebin, Colleen Westendorf-Overley, Lowell Brian Anthony, Philip A. DeSimone, Gaurav Goel, Mahesh R. Kudrimoti, Sean Patrick Dineen, Ching-Wei David Tzeng, Peter J Hosein: Neoadjuvant nab-paclitaxel and gemcitabine (AG) in borderline resectable (BR) or unresectable (UR) locally advanced pancreatic adenocarcinoma (LAPC) in patients ineligible for FOLFIRINOX J Clin Oncol (2016 Gastrointestinal Cancers Symposium) 34 (4S): abstr 328,2016.

Arturo Loaiza-Bonilla, Emma E Furth, Jennifer JD Morrissette: Next-generation sequencing and personalized genomic medicine in hepatobiliary malignancies Hepatic Oncology 2 (4): 359-370,2015.

Arturo Loaiza-Bonilla, Mark H. O'Hara, Maryann Redlinger, Nevena Damjanov, Ursina R. Teitelbaum, Irina Vasilevskaya, Mark Alan Rosen, Daniel F Heitjan, Ravi K. Amaravadi, Peter J. O'Dwyer: Phase II trial of autophagy inhibition using hydroxychloroquine (HCQ) with FOLFOX/bevacizumab in the first-line treatment of advanced colorectal cancer J Clin Oncol 33 (15): abstr 3614,2015.

Loaiza-Bonilla Arturo, Clayton Erica, Furth Emma, O'Hara Mark and Morrissette Jennifer: Dramatic response to dabrafenib and trametinib combination in a BRAF V600E-mutated cholangiocarcinoma: implementation of a molecular tumour board and next-generation sequencing for personalized medicine ecancer 8 (497): 2014.

Peter J. Hosein, Ana Echenique, Arturo Loaiza-Bonilla, Tatiana Froud, Katuzka Barbery, Caio M. Rocha Lima, Jose M. Yrizarry, Govindarajan Narayanan: Percutaneous irreversible electroporation for the treatment of colorectal cancer liver metastases with a proposal for a new response evaluation system J Vasc Interv Radiol. : pii: S1051-0443(14)00442-4.,2014.

Loaiza-Bonilla A, Kittaneh M, Guardiola Amado VD, Kovacs K, Merchan JR.: Preclinical study of cytotoxicity and predictive markers of response to dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 with or without paclitaxel or nab-paclitaxel as a new therapeutic strategy in pancreatic cancer cell lines. J Clin Oncol (ASCO Annual Meeting Abstracts) : 2013.

Hosein Peter J, Macintyre Jessica, Kawamura Carolina, Maldonado Jennifer Cudris, Ernani Vinicius, Loaiza-Bonilla Arturo, Narayanan Govindarajan, Ribeiro Afonso, Portelance Lorraine, Merchan Jaime R, Levi Joe U, Rocha-Lima Caio M: A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma. BMC Cancer 12 : 199,2012.

Newton AD, Datta J, Loaiza-Bonilla A, Karakousis GC, Roses RE: Neoadjuvant therapy for gastric cancer: current evidence and future directions. J Gastrointest Oncol 6 (5): 534-43,2015.

Moh'd M. Khushman, Peter Joel Hosein, Michel Velez, Lauren Carcas, Daniel Joseph Dammrich, Jorge Hurtado-Cordovi, Ritesh Parajuli, Terri Pollack, Jessica Macintyre, Ana Paula P. Harwood, Arturo Loaiza-Bonilla, Ikechukwu Immanuel Akunyili, Maria H. Restrepo, Jaime R. Merchan, Govindarajan Narayanan, Lorraine Portelance, Danny Sleeman, Joe U Levi, Caio Max S. Rocha Lima: Updated survival analysis of patients (pts) with unresectable (UR) or borderline resectable (BR) locally advanced pancreatic adenocarcinoma (LAPC) treated with neoadjuvant FOLFIRINOX. J Clin Oncol (ASCO Annual Meeting Abstracts) 32 : suppl; abstr e15197,2014.

Sofia Palacio, Arturo Loaiza-Bonilla, Muaiad Kittaneh, Christos Kyriakopoulos, Roberto E. Ochoa, Mauricio Escobar, Belisario Arango, Maria H. Restrepo, Jaime R. Merchan, Caio M.S. Rocha Lima, Peter J. Hosein: Successful Use of Trastuzumab with Anthracycline-based Chemotherapy Followed by Trastuzumab Maintenance in Patients with Advanced HER2-positive Gastric Cancer Anticancer Research 34 (1): 301-306,2014.

Socola F, Loaiza-Bonilla A, Benedetto P: Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis: An Unexpected Complication. Case Rep Oncol Med. : 2012.

Loaiza-Bonilla A, Artz A, Salerno F, Leng SX, Yeh S, Biedenbender R, Gravenstein S, Loera J, Geloo ZS and Ershler WB: Correction of Anemia in the Frail Elderly (CAFE): Results of a Randomized, Double-Blind, Placebo-Controlled Study with Darbepoetin Alfa in Elderly Patients with Chronic Unexplained Anemia. Poster Blood 120 (21): 5153,2012.

Mark H. O'Hara, Maryann Gallagher, Ursina R. Teitelbaum, Bruce J. Giantonio, Nevena Damjanov, Arturo Loaiza-Bonilla, Ravi K. Amaravadi, Daniel F Heitjan, Irina Vasilevskaya, Daniel D. Von Hoff, Ramesh K Ramanathan, Dan Laheru, Ana De Jesus-Acosta, Victor E Velculescu, Peter J. O'Dwyer: Phase 1 trial of gemcitabine/nab-paclitaxel in combination with the autophagy inhibitor hydroxychloroquine in previously untreated patients with metastatic pancreatic adenocarcinoma J Clin Oncol (ASCO Meeting Abstracts) 33 : e15213,2015.

P. J. Hosein, C. Kawamura, J. Macintyre, A. Loaiza-Bonilla, J. R. Merchan, J. U. Levi, C. S. Rocha Lima.: Pilot study of neoadjuvant FOLFIRINOX in unresectable locally advanced (LA) pancreatic carcinoma (PC). J Clin Oncol 29 : suppl 4; abstr 324,2011.

Loaiza-Bonilla A, Gluck S.: Using modern molecular markers to tailor breast cancer treatment: a new era for personalized medicine. Breast Cancer Management 1 (2): 105-108,2012.

Loaiza-Bonilla A, Socola F, Gluck S: Clinical utility of aromatase inhibitors as adjuvant treatment in postmenopausal breast cancer. Clinical Medicine Insights: Women's Health 6 : 1-11,2013.

Arturo Loaiza-Bonilla, Katuska J Barbery, Evelyn Perez-Rojas, Tatiana Froud, Jose M Yrizarry, Ikechukwu Immanuel Akunyili, Caio Max S. Rocha Lima, Lynn G. Feun, Peter Joel Hosein, Govindarajan Narayanan.: Percutaneous irreversible electroporation (IRE) in the treatment of hepatocellular carcinoma (HCC) and metastatic colorectal cancer (mCRC) to the liver: A retrospective analysis of the University of Miami experience. J Clin Oncol (ASCO Annual Meeting Abstracts) 30 : suppl 4; abstr 272,2012.

Loaiza-Bonilla Arturo, Rossi Flavia, Alkhalil Bassel: Tracheal carcinoid presenting as refractory cervicalgia in a postpartum patient: correlation versus epiphenomenon. Ear, Nose, & Throat Journal 91 (9): E11-4,2012.

Bojanini Esteban Uribe, Loaiza-Bonilla Arturo, Pimentel Agustin: Prekallikrein deficiency presenting as recurrent cerebrovascular accident: case report and review of the literature. Case Reports In Hematology 2012 : 723204,2012.

Schaefer Eric W, Loaiza-Bonilla Arturo, Juckett Mark, DiPersio John F, Roy Vivek, Slack James, Wu Wenting, Laumann Kristina, Espinoza-Delgado Igor, Gore Steven D: A phase 2 study of vorinostat in acute myeloid leukemia. Haematologica 94 (10): 1375-82,2009.

Academic Contact Info

Division of Hematology/Oncology
Perelman Center for Advanced Medicine
6th Floor South Pavilion
3400 Civic Center Boulevard
Abramson Cancer Center

Philadelphia, PA 19104
Phone: (215) 615-5810
Patient appointments: 800-789-PENN (7366)

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