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Andrew E. Epstein, MD, FAHA, FACC, FHRS

Andrew E. Epstein, MD, FAHA, FACC, FHRS Physician

Professor of Medicine at the Hospital of the University of Pennsylvania and the Veteran's Administration Medical Center

Dr. Epstein is employed by Penn Medicine.

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About Dr. Andrew E. Epstein

Recognized by America's Top Doctors, 2012 - 2018
Recognized by Best Doctors in America 2011, 2012, 2015 - 2018
Recognized in Philadelphia magazine's annual Top Docs issues for 2018 and 2019

Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 1983
  • Internal Medicine, 1980

Clinical Expertise:

  • Atrial Fibrillation (Afib)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Rochester School of Medicine
Residency: Barnes-Jewish Hospital - Washington University, St. Louis
Fellowship: University of Alabama Hospital


Abbott, International American College of Cardiology, National American College of Physicians, National American Heart Association, Alabama Affiliate, Local American Heart Association, National Association of University Cardiologists, National Cardiac Electrophysiology Society, National National Heart, Lung and Blood Institute, National National Institutes of Health, National North American Society of Pacing and Electrophysiology / Heart Rhythm Society, National

Hospital Affiliation

Dr. Epstein is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Defibrillation and cardioversion; devices for the treatment of arrhythmias (implantable cardioverter-defibrillators, pacemakers); Electrophysiology and treatment of atrial and ventricular arrhythmias (interventional electrophysiology/ablation, surgical, pharmacologic); Clinical trials in arrhythmia treatment.

Selected Publications:

Healey JS, Gladstone DJ, Swaminathan B, Eckstein J, Mundl H, EPSTEIN AE, Haeusler KG, Mikulik R, Kasner SE, Toni D, Arauz A, Ntaios G, Hankey GJ, Perera K, Pagola J, Shuaib A, Lutsep H, Yang X, Uchiyama S, Endres M, Coutts SB, Karliński M, Czlonkowska A, Molina CA, Santo G, Berkowitz SD, Hart RG, Connolly SJ.: Recurrent stroke with rivaroxaban compared with aspirin according to predictors of Atrial fibrillation: secondary analysis of the NAVIGATE ESUS randomized clinical trial. JAMA Neurol : 2019.

Shirai Y, Liang JJ, Santangeli P, Arkles JS, Schaller RD, Supple GE, Lin D, Nazarian S, Dixit S, EPSTEIN AE, Callans DJ, Marchlinski FE, Frankel D.: Long-term outcome and mode of recurrence following noninducibility during noninvasive programmed stimulation after ventricular tachycardia ablation. PACE 42 : 333-340,2019.

Arkles JA, EPSTEIN AE.: Leadless pacemakers and the tricuspid valve: Can you believe it? Can this be true? Circ Arrhythm Electrophysiol 12 : 2019;12:e007375.,2019.

Varma N, Love C, Schweikert R, Moll P, Michalski J, EPSTEIN AE.: Automatic remote monitoring utilizing daily transmissions: transmission reliability and ICD battery longevity in the TRUST Trial. Europace 20 : 622-628,2018.

Santangeli P, EPSTEIN AE: Exploring the dark side of left atrial appendage devices J Cardiovas Electrophysiol 29 : 14-16,2018.

Yaeger A, Cash NR, Parham T, Frankel DS, Deo R, Schaller RD, Santangel P, Santangeli P, Nazarian S, Supple GE, Arkles J, Riley MP, Garcia FC, Lin D, EPSTEIN AE, Callans DJ, Marchlinski FE, Kolansky DM, Mora JI, Amaro A, Schwab R, Pack A, Dixit S: A nurse-led limited risk factor modification program to address obesity and obstructive sleep apnea in atrial fibrillation patients J Am Heart Assoc 7 : e010414.DOI:10.1161/JAHA/118.010414,2018.

Khurshid S, Obeng-Gyimah E, Supple GE, Schaller R, Lin D, Owens AT, EPSTEIN AE, Dixit S, Marchlinski FE, Frankel DS: Reversal of pacing-induced cardiomyopathy following cardiac resynchronization therapy. J Am Coll Cardiol 4 : 168-177,2018.

Mendelson TB, Santangeli PM, Frankel DS, Arkles JS, Supple GE, Lin D, Riley MP, Callans DJ, Nazarian S, Hyman MC, Kumareswaran R, EPSTIEN AE, Deo R, Dixit S, Garcia FC, Zado ES, Hutchinson MD, Sadek MM, Cooper JM, Marchlinski FE, Trerotola SO, Schaller RD.: Feasibility of complex trans-femoral electrophysiology procedures in patients with inferior vena cava filters. Heart Rhythm : 2018 Dec 24. pii: S1547-5271(18)31288-8.,2018.

Patel PJ, Katz R, Borovskiy Y, Killian A, Levine JM, McNaughton NW, Callans D, Supple G, Dixit S, EPSTEIN AE, Marchlinski FE, Deo R: Race and stroke in an atrial fibrillation inception cohort: dindings from the Penn Atrial Fibrillation Free Study. Heart Rhythm 15 : 487-483,2018.

Arkles JS, EPSTEIN AE: A WCT in a patient with coronary artery disease. J Innovations Card Rhyth Management 9 : 3059-3061,2018.

Academic Contact Info

Electrophysiology Section
Cardiovascular Division
University of Pennsylvania
3400 Spruce Street
9 Founders

Philadelphia, PA 19104
Phone: (215) 615-4332
Patient appointments: 800-789-7366 (PENN)

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