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Andrew Berton Dancis, MD Physician

Associate Professor of Medicine

Dr. Dancis is employed by Penn Medicine.

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Clinical Specialties


  • Hematology

Programs & Centers:

Board Certification:

  • Hematology, 1984
  • Internal Medicine, 1981
  • Medical Oncology, 1985

Clinical Expertise:

  • Anemia
  • Aplastic Anemia
  • B12 Deficiency Anemia
  • Bleeding Disorders
  • Blood Clotting Disorders (Blood Coagulation)
  • Blood Disorders
  • Blood Platelet Disorders
  • Deep Vein Thrombosis
  • Eosinophilic Granuloma
  • HELLP Syndrome
  • Hemolytic Anemia
  • Hemophilia
  • Histiocytosis
  • Myeloproliferative Neoplasms (MPN)
  • Sickle Cell Diseases
  • Thalassemias
  • White Blood Cell Disorders

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: New York University
Residency: SUNY at Buffalo Medical Center
Fellowship: New York University Medical Center
Fellowship: National Institutes of Health


American Society of Hematology, National

Hospital Affiliation

Dr. Dancis is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: On the medical staff, but does not have privileges to treat patients in the hospital.


Description of Research Expertise:

Research interests:
Study of iron metabolism, iron trafficking, mitochondrial function, heme and Fe-S proteins.

Key words: mitochondria, yeast, Fe-S, heme, frataxin, mitochondrial carrier proteins, pyrimidines, ring sideroblast

Research description:
In most eukaryotes (including yeast and human cells) the essential iron containing cofactors, Fe-S and heme, are made in the mitochondria.
Iron transport across the ion impermeable inner membrane (from cytoplasm into the mitochondrial matrix) is an essential process for cell viability and yet it is poorly characterized. This is surprising but, in fact, calcium transport into mitochondria is only beginning to be understood this year. We have found candidate mitochondrial iron transporters and we are developing assays measuring iron import and iron use in mitochondria. An unanticipated connection to pyrimidine exchange has been discovered and this is a current focus of research. A second object of study is to understand Fe-S cluster biogenesis in mitochondria. Frataxin, a disease gene involved in neurodegeneration, has been implicated in Fe-S cluster assembly. We discovered a bypass mutation that enhances formation of the cluster scaffold intermediate. Further in depth study of how this frataxin bypass occurs should shed light on the process of mitochondrial Fe-S cluster assembly and its regulatory controls.

Rotation Projects (genetic and biochemical)
1. Genetic screen in yeast involving randomization of Isu1 scaffold and isolation of novel suppressor mutants altering Fe-S cluster assembly in mitochondria.
2. Genetic screen in yeast for escape from glutaredoxin deficiency in a grx3/4 minus background.
3. Phenotypic evaluation of a library of essential genes for novel iron trafficking genes/functions.
4. Purification of a 4 way complex (Nfs1/Isd11/Isu1/Yfh1) and characterization of its activity in Fe-S cluster formation on the scaffold.

Academic Contact Info

421 Curie Blvd.

Philadelphia, PA 19104
Phone: (215) 573-6275