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Amit Maity, MD, PhD

Amit Maity, MD, PhD Physician

Director of Quality Assurance/ Quality Improvement, Department of Radiation Oncology, HUP Vice Chair, Clinical Division Morton M. Kligerman Professor, M.D.

Dr. Maity is a Penn Medicine employed physician.

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Clinical Specialties

Specialty:

  • Radiation Oncology

Programs & Centers:

Board Certification:

  • Internal Medicine, 1988
  • Radiation Oncology, 1992

Clinical Expertise:

  • Acute Leukemia
  • Blood Cancer
  • Chronic Lymphocytic Leukemia (CLL)
  • Chronic Myeloid Leukemia (CML)
  • Cutaneous T-Cell Lymphoma
  • Hypothyroidism (Underactive Thyroid)
  • Leiomyosarcoma (LMS)
  • Leukemia
  • Lung Cancer
  • Lymphoma
  • Mediastinal Tumors
  • Metastatic Cancer
  • Non-Hodgkin Lymphoma
  • Radiation Treatment

Practice Locations and Appointments

  • Penn Radiation Oncology

    Perelman Center for Advanced Medicine Concourse Level 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Amerihealth
  • NJ Medicaid
  • NJ Medicare
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Boston University School of Medicine
Residency: Mount Sinai Medical Center
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania
Fellowship: Johns Hopkins Hospital

Memberships

American Association for Cancer Research, National American Board of Radiology, National American Board of Radiology, National American Heart Association, Cellular and Molecular Biology Study Section, National NIH Radiation Therapeutics and Biology (RTB) Study Section, National NIH Radiation Therapy and Biology (RTB) Study Section, National NIH Rapid Access to Intervention Development (RAID) review section, National NIH study section, Experimental Therapeutics Cluster P01 review panel , National NIH study section, Therapeutic Target Development Cluster P01 review panel , National NIH, ZCA1 SRB-1 (J1) NCI R21/R03 grants review panel, National NIH, ZRG1 OTC RTB Member Conflict grant review panel, National Radiation Research Society, National Radiologic Society of North America (RSNA) Radiation Oncology study section, National

Hospital Affiliation

Dr. Maity is a Penn Medicine employed physician.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

RESEARCH INTERESTS:
My laboratory based research focuses on developing strategies of improving the radiation response, using agents that modify the tumor microenvironment and alter cellular signaling. In particular we have focused on the PI3K/mTOR pathway, which is upregulated in many human cancers. Our research suggest that inhibition of this pathway can increase the intrinsic sensitivity of tumor cells to radiation and also decrease tumor oxygenation.
My clinical research focuses on using hypofractionated radiation to potentiate the action of immune checkpoint inhibitors in patient with metastatic solid tumors including melanoma, non small-lung cancer, and breast cancer.

Selected Publications:

Benci JL, Xu B, Qiu Y, Wu TJ, Dada H, Twyman-Saint Victor C, Cucolo L, Lee DS, Pauken KE, Huang AC, Gangadhar TC, Amaravadi RK, Schuchter LM, Feldman MD, Ishwaran H, Vonderheide RH, Maity A, Wherry EJ, Minn AJ.: Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade. Cell 167 (6): 1540-54,2016.

Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Vonderheide RH, Minn AJ: Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520 (7547): 373-7,2015.

Milgrom SA, Jauhari S, Plastaras JP, Nieto Y, Dabaja BS, Pinnix CC, Smith GL, Allen PK, Lukens JN, Maity A, Oki Y, Fanale MA, Nasta SD.: A multi-institutional analysis of peritransplantation radiotherapy in patients with relapsed/refractory Hodgkin lymphoma undergoing autologous stem cell transplantation. Cancer in press : 2016.

Gabriel PE, Woodhouse KD, Lin A, Finlay JC, Young RB, Volz E, Hahn SM, Metz JM, Maity A: An automated electronic system for managing radiation treatment plan peer review reduces missed reviews at a large, high-volume academic center. Practical radiation oncology 6 (6): e307-14,2016.

Cerniglia GJ, Dey S, Gallagher-Colombo SM, Daurio NA, Tuttle S, Busch TM, Lin A, Sun R, Esipova TV, Vinogradov SA, Denko N, Koumenis C, Maity A: The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation. Molecular cancer therapeutics 14 (8): 1928-38,2015.

Kennedy AR, Maity A and Sanzari JK: Radiation Induced Coagulopathy: Potential Prevention Strategies and Treatments Radiation research 186 (2): 121-40,2016.

Lin Alexander, Maity Amit: Molecular Pathways: A Novel Approach to Targeting Hypoxia and Improving Radiotherapy Efficacy via Reduction in Oxygen Demand. Clinical cancer research 21 (9): 1995-2000,2015.

Gandhi SJ, Minn A, Vonderheide RH, Wherry EJ, Hahn SM, Maity A: Awakening the immune system with radiation: Optimal dose and fractionation. Cancer letters 368 (2): 2015.

Thompson RF, Maity A: Radiotherapy and the tumor microenvironment: mutual influence and clinical implications. Advances in Experimental Medicine and Biology 772 : 147-65,2014.

Alonso-Basanta M, Fang P, Maity A, Hahn SM, Lustig RA, Dorsey JF: A Phase I Study of Nelfinavir Concurrent with Temozolomide and Radiotherapy in Patients with Glioblastoma Multiforme. Journal of Neurooncology 116 (2): 365-72,2014.

View all publications

Academic Contact Info

TRC 2West
3400 Civic Center Blvd.

Philadelphia, PA 19104
Phone: (215) 662-3759
Fax: (215) 349-5445
Patient appointments: 800-789-7366 (PENN)

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