Description of Research Expertise:
My laboratory based research focuses on developing strategies of improving the radiation response, using agents that modify the tumor microenvironment and alter cellular signaling. In particular we have focused on the PI3K/mTOR pathway, which is upregulated in many human cancers. Our research suggest that inhibition of this pathway can increase the intrinsic sensitivity of tumor cells to radiation and also decrease tumor oxygenation.
My clinical research focuses on using hypofractionated radiation to potentiate the action of immune checkpoint inhibitors in patient with metastatic solid tumors including melanoma, non small-lung cancer, and breast cancer.
Woodhouse KD, Volz E, Maity A, Gabriel PE, Solberg TD, Bergendahl HW, Hahn SM.: Journey Toward High Reliability: A Comprehensive Safety Program to Improve Quality of Care and Safety Culture in a Large, Multisite Radiation Oncology Department. Journal of oncology practice 12 (5): e603-12,2016.
Gabriel PE, Woodhouse KD, Lin A, Finlay JC, Young RB, Volz E, Hahn SM, Metz JM, Maity A: An automated electronic system for managing radiation treatment plan peer review reduces missed reviews at a large, high-volume academic center. Practical radiation oncology : 2016.
Plastaras JP, Both S, Maity A, Glatstein E: The Lymphomas. Treatment Planning in Radiation Oncology, 4th edition : 2016.
Kennedy AR, Maity A and Sanzari JK: Radiation Induced Coagulopathy: Potential Prevention Strategies and Treatments Radiation research : 2016.
Woodhouse KD, Volz E, Bellerive M, Bergendahl HW, Gabriel PE, Maity A, Hahn SM, Vapiwala N: The implementation and assessment of a quality and safety culture education program in a large radiation oncology department. Practical radiation oncology : 2015.
Cerniglia GJ, Dey S, Gallagher-Colombo SM, Daurio NA, Tuttle S, Busch TM, Lin A, Sun R, Esipova TV, Vinogradov SA, Denko N, Koumenis C, Maity A: The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1a Phosphorylation. Molecular cancer therapeutics 14 (8): 1928-38,2015.
Hill-Kayser Christine E, Gabriel Peter, Volz Edna, Lustig Robert A, Tochner Zelig, Hahn Stephen M, Maity Amit: Factors associated with event reporting in the pediatric radiation oncology population using an electronic incident reporting system. Practical radiation oncology : 2015.
Lin Alexander, Maity Amit: Molecular Pathways: A Novel Approach to Targeting Hypoxia and Improving Radiotherapy Efficacy via Reduction in Oxygen Demand. Clinical cancer research : an official journal of the American Association for Cancer Research 21 (9): 1995-2000,2015.
Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Vonderheide RH, Minn AJ: Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520 (7547): 373-7,2015.
Gabriel PE, Volz E, Bergendahl HW, Burke SV, Solberg TD, Maity A, Hahn SM: Incident learning in pursuit of high reliability: implementing a comprehensive, low-threshold reporting program in a large, multisite radiation oncology department. Joint Commission journal on quality and patient safety / Joint Commission Resources 41 (4): 160-8,2015.
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