Description of Research Expertise:
Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.
Naidoo, N., Zhu, J., Galante, R.J., Lian, J., Strus, E., Lee, A., Keenan, B.T., and Pack, A.I.: Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior Neurobiology of Aging 69 : 10-25,2018.
Feng, Y., Keenan, B.T., Wang, S., Leinwand, S., Wiemken, A., Pack, A.I. and Schwab R.J.: Dynamic upper airway imaging during wakefulness in obese subjects with and without sleep apnea American Journal of Respiratory and Critical Care Medicine : 2018.
Mazzotti, D., Lim, D., Sutherland, K., Bittencourt, L., Mindel, J., Magalang, U., Pack, A., de Chazal, P. and Penzel, T.: Opportunities for utilizing polysomnography signals to personalize obstructive sleep apnea management Physiological Measurement : 2018.
Pak, V.M., Mazzotti, D.R., Keenan, B.T., Hirotsu, C., Gehrman, P., Bittencourt, L., Pack, A.I. and Tufik, S.: Candidate gene analysis in the Sao Paulo Epidemiological Sleep Study (EPISONO) shows an association of variant in PDE4D and sleepiness Sleep Medicine 47 : 106-112,2018.
Perron, I.J., Keenan, B.T., Chellappa, K., Lahens, N.F., Yohn, N.L., Shockley, K.R., Pack, A.I. and Veasey, S.C.: Dietary challenges differentially affect activity and sleep/wake behavior in mus musculus: isolating independent associations with diet/energy balance and body weight PLoS One 13 (5): e0196743,2018.
Pak, V.M., Dai, F., Keenan, B.T., Gooneratne, N.S. and Pack, A.I.: Lower plasma choline levels are associated with sleepiness symptoms Sleep Medicine 44 : 89-96,2018.
Kim, J., Keenan, B.T., Lim, D.C., Lee, S.K., Pack, A.I. and Shin, C.: Symptom-based subgroups of Koreans with obstructive sleep apnea Journal of Clinical Sleep Medicine 14 (3): 437-443,2018.
Younes, M., Kuna, S.T., Pack, A.I., Walsh, J.K., Kushida, C.A., Staley, B., and Pien, G.W.: Reliability of the American Academy of Sleep Medicine rules for assessing depth in clinical practice Journal of Clinical Sleep Medicine 14 (2): 205-2013,2018.
Pien, G.W., Ye, L., Keenan, B.T., Maislin, G., Bjornsdottir, E., Arnardottir, E.S., Benediktsdottir, B., Gislason, T. and Pack, A.I.: Changing faces of OSA: treatment effects by cluster designation in the Icelandic Sleep Apnea Cohort Sleep : 2018.
Keenan, B.T., Kim, J., Singh, B, Bittencourt, L., Chen, N.H., Cistulli, P.A., Magalang, U., McArdle, N., Mindel, J.W., Benediktsdottir, B., Arnardottir, E.S., Prochnow, L.K., Penzel, T., Sanner, B., Schwab, R., Shin, C., Sutherland, K., Tufik, S., Maislin, G., Gislason, T. and Pack, A.I.: Recognizable clinical subtypes of OSA across a worldwide sleep center population: a cluster analysis Sleep : 2018.
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