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Allan I. Pack, MD, PhD

Allan I. Pack, MD, PhD Physician

Chief, Division of Sleep Medicine and Director, Center for Sleep and Respiratory Neurobiology John Miclot Professor

Dr. Pack is employed by Penn Medicine.

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About Dr. Allan I. Pack

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2017

Recognized by Best Doctors in America 2005 - 2018

Recognized annually in Philadelphia Magazine's Top Docs issue from 2004 through 2016

Clinical Specialties


  • Sleep Medicine

Programs & Centers:

Board Certification:

  • Sleep Medicine, 1970

Clinical Expertise:

  • Sleep Apnea
  • Sleep Disorders

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Residency: Glasgow Royal Infirmary
Fellowship: Glasgow Royal Infirmary
Medical School: University of Glasgow


American Academy of Sleep Medicine, 1988-, National American Federation for Clinical Research, National American Society for Clinical Investigation, National American Thoracic Society, National Association of American Physicians, National European Sleep Research Society, International European Society for Clinical Respiratory Physiology, International Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Disorders Study Section, National Institutes of Health, National Sleep and Biological Rhythms (official journal of the Japanese Society of Sleep Research and Asian Society of Sleep Research), International Sleep Research Society, National Society for Neuroscience, National

Hospital Affiliation

Dr. Pack is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Selected Publications:

Feng, Y., Keenan, B.T., Wang, S., Leinwand, S., Wiemken, A., Pack, A.I. and Schwab R.J.: Dynamic upper airway imaging during wakefulness in obese subjects with and without sleep apnea American Journal of Respiratory and Critical Care Medicine 198 (11): 1435-1443,2018.

Feng, Y., Maislin, D., Keenan, B.T., Gislason, T., Arnardottir, E.S., Benediktsdottir, B., Chirinos, J.A., Townsend, R.R., Staley, B., Pack, F.M., Sifferman, A., Pack, A.I. and Kuna, S.T.: Physical activity following positive airway pressure treatment in adults with and without obesity and with moderate-severe obstructive sleep apnea Journal of Clinical Sleep Medicine 14 (10): 1705-1715,2018.

Varendh, M., Andersson, M., Bjornsdottir, E., Arnardottir, E.S., Gislason, T., Pack, A.I, Hrubos-Strom, H., Johannisson A. and Juliusson, S.: PAP treatment in patients with OSA does not induce long-term nasal obstruction Journal of Sleep Research : 2018.

Thorarinsdottir, E.H., Arnardottir, E.S., Benediktsdottir, B., Janson, C., Olafsson, I., Pack, A.I., Gislason, T. and Keenan B.T.: Serum ferritin and obstructive sleep apnea-epidemiological study Sleep & Breathing 22 (3): 663-672,2018.

Naidoo, N., Zhu, J., Galante, R.J., Lian, J., Strus, E., Lee, A., Keenan, B.T., and Pack, A.I.: Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior Neurobiology of Aging 69 : 10-25,2018.

Magalang, U.J., Johns, J.N., Wood, K.A., Mindel, J.W., Lim, D.C., Bittencourt, L.R., Chen, N.H., Cistulli, P.A., Gislason, T., Arnardottir, E.S., Penzel, T., Tufik, S. and Pack, A.I.: Home sleep apnea testing: comparison of manual and automated scoring across international sleep centers Sleep and Breathing : 2018.

van Hees, V.T., Sabia, S., Jones, S.E., Wood, A.R., Anderson, K.N., Kivimaki, M., Frayling, T.M., Pack, A.I., Bucan, M., Trenell, M.I., Mazzotti, D.R., Gehrman, P.R., Singh-Manoux, B.A. and Weedon, M.N.: Estimating sleep parameters using an accelerometer without sleep diary Scientific Reports 8 (1): 12975,2018.

Pak, V.M., Mazzotti, D.R., Keenan, B.T., Hirotsu, C., Gehrman, P., Bittencourt, L., Pack, A.I. and Tufik, S.: Candidate gene analysis in the Sao Paulo Epidemiological Sleep Study (EPISONO) shows an association of variant in PDE4D and sleepiness Sleep Medicine 47 : 106-112,2018.

Mazzotti, D.R., Lim, D.C., Sutherland, K., Bittencourt, L., Mindel, J.W., Magalang, U., Pack, A.I., de Chazal, P. and Penzel, T.: Opportunities for utilizing polysomnography signals to characterize obstructive sleep apnea subtypes and severity Physiological Measurement 39 (9): 09TR01,2018.

Perron, I.J., Keenan, B.T., Chellappa, K., Lahens, N.F., Yohn, N.L., Shockley, K.R., Pack, A.I. and Veasey, S.C.: Dietary challenges differentially affect activity and sleep/wake behavior in mus musculus: isolating independent associations with diet/energy balance and body weight PLoS One 13 (5): e0196743,2018.

View all publications

Academic Contact Info

Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100

Philadelphia, PA 19104-3403
Phone: (215) 746-4806
Patient appointments: 800-789-7366 (PENN)

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