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Allan I. Pack, MD, PhD

Allan I. Pack, MD, PhD Physician

Chief, Division of Sleep Medicine and Director, Center for Sleep and Respiratory Neurobiology John Miclot Professor

Dr. Pack is employed by Penn Medicine.

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About Dr. Allan I. Pack

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2017

Recognized by Best Doctors in America 2005 - 2018

Recognized annually in Philadelphia Magazine's Top Docs issue from 2004 through 2016

Clinical Specialties

Specialty:

  • Sleep Medicine

Programs & Centers:

Board Certification:

  • Sleep Medicine, 1970

Clinical Expertise:

  • Sleep Apnea
  • Sleep Disorders

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Residency: Glasgow Royal Infirmary
Fellowship: Glasgow Royal Infirmary
Medical School: University of Glasgow

Memberships

American Academy of Sleep Medicine, 1988-, National American Federation for Clinical Research, National American Society for Clinical Investigation, National American Thoracic Society, National Association of American Physicians, National European Sleep Research Society, International European Society for Clinical Respiratory Physiology, International Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Disorders Study Section, National Institutes of Health, National Sleep and Biological Rhythms (official journal of the Japanese Society of Sleep Research and Asian Society of Sleep Research), International Sleep Research Society, National Society for Neuroscience, National

Hospital Affiliation

Dr. Pack is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Selected Publications:

Sutherland, K., Keenan, B.T., Bittencourt, L., Chen, N.H., Gislason, T., Leinwand, S., Magalang, U.J., Maislin, G., Mazzotti, D.R., McArdle, N., Mindel, J., Pack, A.I., Penzel, T., Singh, B., Tufik, S., Schwab, R.J., Cistulli, P.A. and SAGIC Investigators: A global comparison of anatomic risk factors and their relationship to obstructive sleep apnea severity in clinical samples Journal of Clinical Sleep Medicine : 2019.

Chang, Y., Xu, L., Han, F., Keenan, B.T., Kneeland-Szanto, E., Zhang, R., Zhang, W., Yu, Y., Zuo, Y., Pack, A.I. and Kuna, S.T.: Validation of the Nox-T3 portable monitor for diagnosis of obstructive sleep apnea in patients with chronic obstructive pulmonary disease Journal of Clinical Sleep Medicine : 2019.

Feng, Y., Keenan, B.T., Wang, S., Leinwand, S., Wiemken, A., Pack, A.I. and Schwab R.J.: Dynamic upper airway imaging during wakefulness in obese subjects with and without sleep apnea American Journal of Respiratory and Critical Care Medicine 198 (11): 1435-1443,2018.

Feng, Y., Maislin, D., Keenan, B.T., Gislason, T., Arnardottir, E.S., Benediktsdottir, B., Chirinos, J.A., Townsend, R.R., Staley, B., Pack, F.M., Sifferman, A., Pack, A.I. and Kuna, S.T.: Physical activity following positive airway pressure treatment in adults with and without obesity and with moderate-severe obstructive sleep apnea Journal of Clinical Sleep Medicine 14 (10): 1705-1715,2018.

Magalang, U.J., Johns, J.N., Wood, K.A., Mindel, J.W., Lim, D.C., Bittencourt, L.R., Chen, N.H., Cistulli, P.A., Gislason, T., Arnardottir, E.S., Penzel, T., Tufik, S. and Pack, A.I.: Home sleep apnea testing: comparison of manual and automated scoring across international sleep centers Sleep and Breathing : 2018.

Thorarinsdottir, E.H., Arnardottir, E.S., Benediktsdottir, B., Janson, C., Olafsson, I., Pack, A.I., Gislason, T. and Keenan B.T.: Serum ferritin and obstructive sleep apnea-epidemiological study Sleep & Breathing 22 (3): 663-672,2018.

Varendh, M., Andersson, M., Bjornsdottir, E., Arnardottir, E.S., Gislason, T., Pack, A.I, Hrubos-Strom, H., Johannisson A. and Juliusson, S.: PAP treatment in patients with OSA does not induce long-term nasal obstruction Journal of Sleep Research : 2018.

Naidoo, N., Zhu, J., Galante, R.J., Lian, J., Strus, E., Lee, A., Keenan, B.T., and Pack, A.I.: Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior Neurobiology of Aging 69 : 10-25,2018.

van Hees, V.T., Sabia, S., Jones, S.E., Wood, A.R., Anderson, K.N., Kivimaki, M., Frayling, T.M., Pack, A.I., Bucan, M., Trenell, M.I., Mazzotti, D.R., Gehrman, P.R., Singh-Manoux, B.A. and Weedon, M.N.: Estimating sleep parameters using an accelerometer without sleep diary Scientific Reports 8 (1): 12975,2018.

Pak, V.M., Mazzotti, D.R., Keenan, B.T., Hirotsu, C., Gehrman, P., Bittencourt, L., Pack, A.I. and Tufik, S.: Candidate gene analysis in the Sao Paulo Epidemiological Sleep Study (EPISONO) shows an association of variant in PDE4D and sleepiness Sleep Medicine 47 : 106-112,2018.

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Academic Contact Info

Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100

Philadelphia, PA 19104-3403
Phone: (215) 746-4806
Patient appointments: 800-789-7366 (PENN)

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