Description of Research Expertise:
Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.
Sutherland, K., Keenan, B.T., Bittencourt, L., Chen, N.H., Gislason, T., Leinwand, S., Magalang, U.J., Maislin, G., Mazzotti, D.R., McArdle, N., Mindel, J., Pack, A.I., Penzel, T., Singh, B., Tufik, S., Schwab, R.J., Cistulli, P.A. and SAGIC Investigators: A global comparison of anatomic risk factors and their relationship to obstructive sleep apnea severity in clinical samples Journal of Clinical Sleep Medicine 15 (4): 629-639,2019.
Chang, Y., Xu, L., Han, F., Keenan, B.T., Kneeland-Szanto, E., Zhang, R., Zhang, W., Yu, Y., Zuo, Y., Pack, A.I. and Kuna, S.T.: Validation of the Nox-T3 portable monitor for diagnosis of obstructive sleep apnea in patients with chronic obstructive pulmonary disease Journal of Clinical Sleep Medicine 15 (4): 587-596,2019.
Mazzotti, D.R., Keenan, B.T., Lim, D.C., Gottlieb, D.J., Kim, J. and Pack A.I.: Symptom subtypes of obstructive sleep apnea predict incidence of cardiovascular outcomes American Journal of Respiratory and Critical Care Medicine : 2019.
Feng, Y., Keenan, B.T., Wang, S., Leinwand, S., Wiemken, A., Pack, A.I. and Schwab R.J.: Dynamic upper airway imaging during wakefulness in obese subjects with and without sleep apnea American Journal of Respiratory and Critical Care Medicine 198 (11): 1435-1443,2018.
Shulman, R., Cohen, D.L., Grandner, M.A., Gislason, T., Pack, A.I., Kuna, S.T., Townsend, D.R. and Cohen, J.B.: Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications Journal of Clinical Hypertension 20 (12): 1712-1720,2018.
Feng, Y., Maislin, D., Keenan, B.T., Gislason, T., Arnardottir, E.S., Benediktsdottir, B., Chirinos, J.A., Townsend, R.R., Staley, B., Pack, F.M., Sifferman, A., Pack, A.I. and Kuna, S.T.: Physical activity following positive airway pressure treatment in adults with and without obesity and with moderate-severe obstructive sleep apnea Journal of Clinical Sleep Medicine 14 (10): 1705-1715,2018.
Magalang, U.J., Johns, J.N., Wood, K.A., Mindel, J.W., Lim, D.C., Bittencourt, L.R., Chen, N.H., Cistulli, P.A., Gislason, T., Arnardottir, E.S., Penzel, T., Tufik, S. and Pack, A.I.: Home sleep apnea testing: comparison of manual and automated scoring across international sleep centers Sleep and Breathing : 2018.
Thorarinsdottir, E.H., Arnardottir, E.S., Benediktsdottir, B., Janson, C., Olafsson, I., Pack, A.I., Gislason, T. and Keenan B.T.: Serum ferritin and obstructive sleep apnea-epidemiological study Sleep & Breathing 22 (3): 663-672,2018.
Varendh, M., Andersson, M., Bjornsdottir, E., Arnardottir, E.S., Gislason, T., Pack, A.I, Hrubos-Strom, H., Johannisson A. and Juliusson, S.: PAP treatment in patients with OSA does not induce long-term nasal obstruction Journal of Sleep Research : 2018.
Naidoo, N., Zhu, J., Galante, R.J., Lian, J., Strus, E., Lee, A., Keenan, B.T., and Pack, A.I.: Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior Neurobiology of Aging 69 : 10-25,2018.
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