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Allan I. Pack, MD, PhD

Allan I. Pack, MD, PhD Physician

John Miclot Professor

Dr. Pack is employed by Penn Medicine.

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About Dr. Allan I. Pack

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2017

Recognized by Best Doctors in America 2005 - 2018

Recognized annually in Philadelphia Magazine's Top Docs issue from 2004 through 2016

Clinical Specialties


  • Sleep Medicine

Programs & Centers:

Board Certification:

  • Sleep Medicine, 1970

Clinical Expertise:

  • Actigraphy
  • Bilevel Positive Airway Pressure
  • Bruxism
  • Cataplexy
  • Central Sleep Apnea
  • Circadian Rhythm Sleep-Wake Disorders
  • Cognitive Behavioral Therapy
  • Confusional Arousals
  • Continuous Positive Airway Pressure (CPAP)
  • Daytime Sleepiness
  • Enuresis
  • Home Sleep Study
  • Hypersomnia
  • Hypoglossal Nerve Stimulator
  • Inspire Therapy
  • Kline-Levin Syndrome
  • Maintenance of Wakefulness Test
  • Maxillomandibular Advancement
  • Mouth Guard
  • Multiple Sleep Latency Testing
  • Narcolepsy
  • Nightmares
  • Non-Invasive Ventilation
  • Obesity Hypoventilation Syndrome
  • Obstructive Sleep Apnea
  • Parasomnias
  • Periodic Limb Movement Disorder
  • Periodic Paralysis
  • Polysomnography
  • Restless Leg Syndrome (RLS)
  • Shift Work Sleep Disorder
  • Sleep Abnormalities
  • Sleep Apnea
  • Sleep Apnea Study
  • Sleep Apnea-Related Seizure Disorders
  • Sleep Deprivation
  • Sleep Disorders
  • Sleep Endoscopy
  • Sleep Paralysis
  • Sleep Phase Disorder
  • Sleep Related Hallucinations
  • Sleep Related Hypoxemia
  • Sleep Talking
  • Sleep-Related Eating Disorder
  • Sleep-Related Hypoventilation
  • Sleepwalking
  • Snoring
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Residency: Glasgow Royal Infirmary
Fellowship: Glasgow Royal Infirmary
Medical School: University of Glasgow


American Academy of Sleep Medicine, 1988-, National American Federation for Clinical Research, National American Society for Clinical Investigation, National American Thoracic Society, National Association of American Physicians, National European Sleep Research Society, International European Society for Clinical Respiratory Physiology, International Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Disorders Study Section, National Institutes of Health, National Sleep and Biological Rhythms (official journal of the Japanese Society of Sleep Research and Asian Society of Sleep Research), International Sleep Research Society, National Society for Neuroscience, National

Hospital Affiliation

Dr. Pack is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs three training grants from the National Institutes of Health.

Selected Publications:

Sarantopoulou, D., Tang, S.Y., Ricciotti, E., Lahens, N.F., Lekkas, D., Schug, J., Guo, X.S., Paschos, G.K., FitzGerald, G.A., Pack, A.I. and Grant, G.R.: Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input Scientific Reports 9 (1): 13477,2019.

Kuna, S.T., Townsend, R.R., Keenan, B.T., Maislin, D., Gislason, T., Benediktsdottir, B., Gudmundsdottir, S., Arnardottir, E.S., Sifferman, A., Staley, B., Pack, F.M., Guo, X., Schwab, R.J., Maislin, G., Chirinos, J.A. and Pack, A.I.: Blood pressure response to treatment of obese vs non-obese adults with sleep apnea Journal of Clinical Hypertension : doi: 10.1111/jch.13689,2019.

Mazzotti, D.R., Keenan, B.T., Lim, D.C., Gottlieb, D.J., Kim, J. and Pack A.I.: Symptom subtypes of obstructive sleep apnea predict incidence of cardiovascular outcomes American Journal of Respiratory and Critical Care Medicine 200 (4): 493-506,2019.

Sutherland, K., Keenan, B.T., Bittencourt, L., Chen, N.H., Gislason, T., Leinwand, S., Magalang, U.J., Maislin, G., Mazzotti, D.R., McArdle, N., Mindel, J., Pack, A.I., Penzel, T., Singh, B., Tufik, S., Schwab, R.J., Cistulli, P.A. and SAGIC Investigators: A global comparison of anatomic risk factors and their relationship to obstructive sleep apnea severity in clinical samples Journal of Clinical Sleep Medicine 15 (4): 629-639,2019.

Chang, Y., Xu, L., Han, F., Keenan, B.T., Kneeland-Szanto, E., Zhang, R., Zhang, W., Yu, Y., Zuo, Y., Pack, A.I. and Kuna, S.T.: Validation of the Nox-T3 portable monitor for diagnosis of obstructive sleep apnea in patients with chronic obstructive pulmonary disease Journal of Clinical Sleep Medicine 15 (4): 587-596,2019.

Magalang, U.J., Johns, J.N., Wood, K.A., Mindel, J.W., Lim, D.C., Bittencourt, L.R., Chen, N.H., Cistulli, P.A., Gislason, T., Arnardottir, E.S., Penzel, T., Tufik, S. and Pack, A.I.: Home sleep apnea testing: comparison of manual and automated scoring across international sleep centers Sleep and Breathing 23 (1): 25-31,2019.

Guo, X., Keena, B.T., Sarantopoulou, D., Lim, D.C., Lian, J., Grant. G.R. and Pack, A.I.: Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex Aging Cell 00 : e13021,2019.

Feng, Y., Keenan, B.T., Wang, S., Leinwand, S., Wiemken, A., Pack, A.I. and Schwab R.J.: Dynamic upper airway imaging during wakefulness in obese subjects with and without sleep apnea American Journal of Respiratory and Critical Care Medicine 198 (11): 1435-1443,2018.

Shulman, R., Cohen, D.L., Grandner, M.A., Gislason, T., Pack, A.I., Kuna, S.T., Townsend, D.R. and Cohen, J.B.: Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications Journal of Clinical Hypertension 20 (12): 1712-1720,2018.

Feng, Y., Maislin, D., Keenan, B.T., Gislason, T., Arnardottir, E.S., Benediktsdottir, B., Chirinos, J.A., Townsend, R.R., Staley, B., Pack, F.M., Sifferman, A., Pack, A.I. and Kuna, S.T.: Physical activity following positive airway pressure treatment in adults with and without obesity and with moderate-severe obstructive sleep apnea Journal of Clinical Sleep Medicine 14 (10): 1705-1715,2018.

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Academic Contact Info

Translational Research Laboratories
125 South 31st Street, Suite 2100

Philadelphia, PA 19104-3403
Phone: (215) 746-4806
Patient appointments: 800-789-7366 (PENN)

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