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Allan I. Pack, MD, PhD

Allan I. Pack, MD, PhD Physician

Chief, Division of Sleep Medicine and Director, Center for Sleep and Respiratory Neurobiology John Miclot Professor

Dr. Pack is employed by Penn Medicine.

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About Dr. Allan I. Pack

Recognized annually in Philadelphia Magazine's Top Docs issue from 2004 through 2016

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012-14

Recognized by Best Doctors in America 2005-2006, 2007-2008, 2009-2010, 2011-2012, 2013-2014

Clinical Specialties


  • Sleep Medicine

Programs & Centers:

Board Certification:

  • Sleep Medicine, 1970

Clinical Expertise:

  • Sleep Apnea
  • Sleep Disorders

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicare
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Residency: Glasgow Royal Infirmary
Fellowship: Glasgow Royal Infirmary
Medical School: University of Glasgow


American Academy of Sleep Medicine, 1988-, National American Association for the Advancement of Science, National American Federation for Clinical Research, National American Lung Association Research Grant Review Committee, National American Lung Association/Southeastern Pennsylvania, Local American Physiological Society, National American Sleep Apnea Association, National American Society for Clinical Investigation, National American Thoracic Society, National Association for the Advancement of Automotive Medicine, National Association of American Physicians, National European Sleep Research Society, International European Society for Clinical Respiratory Physiology, International National Center for Sleep Disorders Research, National Heart, Lung and Blood Institute, National Institutes of Health, National National Sleep Foundation, National Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Disorders Study Section, National Institutes of Health, National New York Academy of Sciences, National Pennsylvania Society for Pulmonary Disease, Local Pennsylvania Thoracic Society, Local Philadelphia Peripatetic Club, Local Royal College of Physicians and Surgeons of Glasgow , International Sleep and Biological Rhythms (official journal of the Japanese Society of Sleep Research and Asian Society of Sleep Research), International Sleep Research Society, National Society for Neuroscience, National

Hospital Affiliation

Dr. Pack is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Selected Publications:

Pak, V.M., Dai, F., Keenan, B.T., Gooneratne, N. and Pack: Lower plasma choline levels are associated with sleepiness symptoms Sleep Medicine : 2017 (in press).

Chirinos, D.A., Gurubhagavatula, I., Broderick, P., Chirinos, J.A., Teff, K., Wadden, T., Maislin, G., Saif, H., Chittams, J., Cassidy, C., Hanlon, A.L. and Pack: Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways Journal of Behavioral Medicine 40 (6): 955-963,2017.

Jain, S., Gurubhagavatula, I, Townsend, R., Kuna, S.T., Teff, K, Wadden, T.a., Chittams, J., Hanlon, A.L., Maislin, G., Saif, H., Broderick, P., Ahmad, Z., Pack, A.I. and Chirinos: Effect of CPAP, weight loss, or CPAP plus weight loss on central hemodynamics and arterial stiffness Hypertension 70 (6): 1283-1290,2017.

Chirinos, D.A., Gurubhagavatula, I., Broderick, P., Chirinos, J.A., Teff, K., Wadden, T., Maislin, G., Saif, H., Chittams, J., Cassidy, C., Hanlon, A.L. and Pack: Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways Journal of Behavioral Medicine 40 (6): 955-963,2017.

Gao, X., Azarbarzin, A., Keenan, B.T., Ostrowski, M., Pack, F.M., Staley, B., Maislin, G., Pack, A.I., Younes, M. and Kuna: Heritability of heart rate response to arousals in twins Sleep 40 (6): 2017.

Nikonova, E.V., Gilliland, J.D.A., Tanis, K.Q., Podtelezhnikov, A.A., Rigby, A.M., Galante, R.J., Finney, E.M., Stone, D.J., Renger, J.J., Pack, A.I. and Winrow: Transcriptional profiling of cholinergic neurons from basal forebrain identifies changes in expression of genes between sleep and wake Sleep 40 (6): 2017.

Morgan, A.P., Gatti, D.M., Najarian, M.L., Keane, T.M., Galante, R.J., Pack, A.I., Mott, R., Churchill, G.A., de Villena: Structural variation shapes the landscape of recombination in mouse Genetics 206 (2): 603-619,2017.

Xu, L., Han, F., Keenan, B.T., Kneeland-Szanto, E., Yan, H., Dong, X., Chang, Y., Zhao, L., Zhang, X., Li, J., Pack, A.I. and Kuna: Validation of the Nox-T3 portable monitor for diagnosis and obstructive sleep apnea in Chinese adults Journal of Clinical Sleep Medicine 13 (5): 675-683,2017.

Li, J., Chang, Y.P., Riegel, B., Keenan, B.T., Varrasse, M., Pack, A.I. and Gooneratne: Intermediate, but not extended, afternoon naps may preserve cognition in Chinese older adults Journals of Gerontology. Series A, Biological Sciences and Medical Sciences : 2017.

Gerstner, J.R., Perron, I.J., Riedy, S.M., Yoshikawa, T., Kadotani, H., Owada, Y., Van Dongen, H.P.A., Galante, R.J., Dickinson, K., Yin, J.C.P., Pack, A.I. and Frank: Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7 Science Advances 3 (4): e1602663,2017.

Eyseinsdottir, B., Gislason, T., Pack, A.I., Benediktsdottir, B., Arnardottir, E.S., Kuna, S.T. and Bjornsdottir: Insomnia complaints in lean obstructive sleep apnea patients negatively affect positive airway pressure treatment adherence Journal of Sleep Research 26 (2): 2017.

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Academic Contact Info

Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100

Philadelphia, PA 19104-3403
Phone: (215) 746-4806
Patient appointments: 800-789-7366 (PENN)

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