Description of Research Expertise:
Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.
Lim, D.C., Brady, D.C., Soans, R., Kim, E.Y., Valverde, L., Keenan, B.T., Guo, X., Kim, W.Y., Park, M.J., Galante, R.J., Shackleford, J.A. and Pack, A.I.: Different cyclical intermittent hypoxia severities have different effects on hippocampal microvasculature Journal of Applied Physiology (1985) 121 (1): 78-88,2016.
Prasad, B., Usmani, S., Steffen, A.D., Van Dongen, H., Pack, F.M., Strakovsky, I., Staley, B., Dinges, D., Maislin, G., Pack, A.I. and Weaver, T.E.: Short-term variability in apnea-hypopnea index during extended home portable monitoring Journal of Clinical Sleep Medicine 12 (6): 855-863,2016.
Benotti, P., Wood, G.C., Argyropoulos, G., Pack, A., Keenan, B.T., Gao, X., Gerhard, G. and Still, C.: The impact of obstructive sleep apnea on nonalcoholic fatty liver disease in patients with severe obesity Obesity 24 (4): 871-877,2016.
Mullington, J.M., Abbott, .SM., Carroll, J.E., Dijk, D.J., Dinges, D.F., Gehrman, P.R., Ginsburg, G.S., Gozal, D., Haack, M., Lim, D.C., Macrea, M., Pack, A.I., Plante, D.T., Teske, J.A. and Zee, P.C.: Developing biomarker arrays predicting sleep and circadian-coupled risks to health Sleep 39 (4): 727-736,2016.
Magalang, U.J., Arnardottir, E.S., Chen, N.H., Cistulli, P.A., Gislason, T., Lim, D., Penzel, T., Schwab, R., Tufik, S. and Pack, A.I.: Agreement in the scoring of respiratory events among international sleep centers for home sleep testing Journal of Clinical Sleep Medicine 12 (1): 71-77,2016.
Bjornsdottir, E., Benediktsdottir, B., Pack, A.I., Arnardottir, E.S., Kuna, S.T., Gislason, T., Keenan, B.T., Maislin, G. and Sigurdsson, J.F.: The prevalence of depression among untreated obstructive sleep apnea patients using a standardized psychiatric interview Journal of Clinical Sleep Medicine 12 (1): 105-112,2016.
Lyons, M.M., Bhatt, N.Y., Kneeland-Szanto, E., Keenan, B.T., Pechar, J., Stearns, B., Elkassabany, N.M., Memtsoudis, S.G., Pack, A.I. and Gurubhagavatula, I.: Sleep apnea in total joint arthroplasty patients and the role for cardiac biomarkers for risk stratification: an exploration of feasibility Biomarkers in Medicine 10 (3): 265-300,2016.
Soans, R.E., Lim, D.C., Keenan, B.T., Pack, A.I. and Shackleford, J.A.: Automated protein localization of blood brain barrier vasculature in brightfield IHC images PLoS One 11 (2): e0148411,2016.
Parthasarathy, S., Carskadon, M.A., Jean-Louis, G., Owens, J., Bramoweth, A., Combs, D., Hale, L., Harrison, E., Hart, C.N., Hasler, B.P., Honaker, S.M. Hertenstein, E., Kuna, S., Kushida, C., Levenson, J.C., Murray, C., Pack, A.I., Pillai, V., Pruiksma, K., Seixas, A., Strollo, P. Thosar, S.S., Williams, N. and Buysse, D.: Implementation of sleep and circadian science: recommendation from the Sleep Research Society and National Institutes of Health workshop Sleep : 2016.
Watson, N.F., Buchwald, D., Delrow, J.J., Altemeier, W.A., Vitiello, M.V., Pack, A.I., Bamshad, M., Noonan, C. and Gharib, S.: Transcriptional signatures of sleep duration discordance in monozygotic twins Sleep : 2016.
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