Description of Research Expertise:
Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.
Gao, X., Azarbarzin, A., Keenan, B.T., Ostrowski, M., Pack, F.M., Staley, B., Maislin, G., Pack, A.I., Younes, M. and Kuna, S.T.: Heritability of heart rate response to arousals in twins Sleep 40 (6): 2017.
Nikonova, E.V., Gilliland, J.D.A., Tanis, K.Q., Podtelezhnikov, A.A., Rigby, A.M., Galante, R.J., Finney, E.M., Stone, D.J., Renger, J.J., Pack, A.I. and Winrow, C.J.: Transcriptional profiling of cholinergic neurons from basal forebrain identifies changes in expression of genes between sleep and wake Sleep 40 (6): 2017.
Morgan, A.P., Gatti, D.M., Najarian, M.L., Keane, T.M., Galante, R.J., Pack, A.I., Mott, R., Churchill, G.A., de Villena, F.P.: Structural variation shapes the landscape of recombination in mouse Genetics 206 (2): 603-619,2017.
Xu, L., Han, F., Keenan, B.T., Kneeland-Szanto, E., Yan, H., Dong, X., Chang, Y., Zhao, L., Zhang, X., Li, J., Pack, A.I. and Kuna, S.T.: Validation of the Nox-T3 portable monitor for diagnosis and obstructive sleep apnea in Chinese adults Journal of Clinical Sleep Medicine 13 (5): 675-683,2017.
Gerstner, J.R., Perron, I.J., Riedy, S.M., Yoshikawa, T., Kadotani, H., Owada, Y., Van Dongen, H.P.A., Galante, R.J., Dickinson, K., Yin, J.C.P., Pack, A.I. and Frank, M.G.: Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7 Science Advances 3 (4): e1602663,2017.
Kim, J., Pack, A.I., Riegel, B.J., Chirinos, J.A., Hanlon, A., Lee, S.K., and Shin, C.: Objecive snoring time and carotid intima-media thickness in non-apneic female snorers Journal of Sleep Research 26 (2): 147-150,2017.
Eyseinsdottir, B., Gislason, T., Pack, A.I., Benediktsdottir, B., Arnardottir, E.S., Kuna, S.T. and Bjornsdottir, E.: Insomnia complaints in lean obstructive sleep apnea patients negatively affect positive airway pressure treatment adherence Journal of Sleep Research 26 (2): 2017.
Lyons, M.M., Keenan, B.T., Li, J., Khan, T., Elkasabanny, N., Walsh, C.M., Williams, N.N., Pack, A.I. and Gurubhagavatula, I.: Symptomless multi-variable apnea prediction index assesses obstructive sleep apnea risk and adverse outcomes in elective surgery Sleep 40 (3): 2017.
Zimmerman, J.E., Chan, M.T., Lenz, O.T., Keenan, B.T., Maislin, G. and Pack, A.I.: Glutamate is a wake active neurotransmitter in Drosophila melanogaster Sleep 40 (2): 2017.
Kalmbach, D.A., Schneider, L.D., Cheung, J., Bertrand, S.J., Kariharan, T., Pack, A.I. and Gehrman, P.R.: Genetic basis of chronotype in humans: Insights from three landmark GWAS Sleep 40 (2): 2017.
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