Description of Research Expertise:
Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.
Nikonova, E.V., Gilliland, J.D.A., Tanis, K.Q., Podtelezhnikov, A.A., Rigby, A.M., Galante, R.J., Finney, E.M., Stone, D.J., Renger, J.J., Pack, A.I. and Winrow, C.J.: Transcriptional profiling of cholinergic neurons from basal forebrain identifies changes in expression of genes between sleep and wake Sleep : 2017 (in press).
Kim, J., Pack, A.I., Riegel, B.J., Chirinos, J.A., Hanlon, A., Lee, S.K., and Shin, C.: Objecive snoring time and carotid intima-media thickness in non-apneic female snorers Journal of Sleep Research 26 (2): 147-150,2017.
Zimmerman, J.E., Chan, M.T., Lenz, O.T., Keenan, B.T., Maislin, G. and Pack, A.I.: Glutamate is a wake active neurotransmitter in Drosophila melanogaster Sleep : 2017.
Matura, L.A., Fargo, J., Fritz, J.S., Smith, K.A., Vaidya, A., Pinder, D., Archer-Chicko, C., Palevsky, H.I., Pack, A.I., Sommers, M.S. and Kawut, S.M.: Slow-paced respiration therapy to treat symptoms in pulmonary arterial hypertension Heart Lung 46 (1): 7-13,2017.
Watson, N.F., Buchwald, D., Delrow, J.J., Altemeier, W.A., Vitiello, M.V., Pack, A.I., Bamshad, M., Noonan, C. and Gharib, S.: Transcriptional signatures of sleep duration discordance in monozygotic twins Sleep : 2017.
Kalmbach, D.A., Schneider, L.D., Cheung, J., Bertrand, S.J., Kariharan, T., Pack, A.I. and Gehrman, P.R.: Genetic basis of chronotype in humans: Insights from three landmark GWAS Sleep : 2017.
Modarres, M., Kuzma, N.N., Kretzmer, T., Pack, A.I., Lim, M.M.: EEG slow waves in traumatic brain injury: convergent findings in mouse and man Neurobiology of Sleep and Circadian Rhythms : 2016.
Parthasarathy, S., Carskadon, M.A., Jean-Louis, G., Owens, J., Bramoweth, A., Combs, D., Hale, L., Harrison, E., Hart, C.N., Hasler, B.P., Honaker, S.M. Hertenstein, E., Kuna, S., Kushida, C., Levenson, J.C., Murray, C., Pack, A.I., Pillai, V., Pruiksma, K., Seixas, A., Strollo, P. Thosar, S.S., Williams, N. and Buysse, D.: Implementation of sleep and circadian science: recommendation from the Sleep Research Society and National Institutes of Health workshop Sleep 39 (12): 2061-2075,2016.
Phan, T.S., Li, J.K., Segers, P., Reddy-Koppula, M., Akers, S.R., Kuna, S.T., Gislason, T., Pack, A.I. and Chirinos, J.A.: Aging is associated with an earlier arrival of reflected waves without a distal shift in reflection sites Journal of the American Heart Association 5 (9): pii: e003733,2016.
Lim, D.C., Brady, D.C., Soans, R., Kim, E.Y., Valverde, L., Keenan, B.T., Guo, X., Kim, W.Y., Park, M.J., Galante, R.J., Shackleford, J.A. and Pack, A.I.: Different cyclical intermittent hypoxia severities have different effects on hippocampal microvasculature Journal of Applied Physiology (1985) 121 (1): 78-88,2016.
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