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Allan I. Pack, MD, PhD

Allan I. Pack, MD, PhD Physician

Chief, Division of Sleep Medicine and Director, Center for Sleep and Respiratory Neurobiology John Miclot Professor

Dr. Pack is a Penn Medicine employed physician.

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About Dr. Allan I. Pack

Recognized annually in Philadelphia Magazine's Top Docs issue from 2004 through 2016

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012-14

Recognized by Best Doctors in America 2005-2006, 2007-2008, 2009-2010, 2011-2012, 2013-2014

Clinical Specialties


  • Sleep Medicine

Programs & Centers:

Board Certification:

  • Sleep Medicine, 1970

Clinical Expertise:

  • Sleep Apnea
  • Sleep Disorders

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Residency: Glasgow Royal Infirmary
Fellowship: Glasgow Royal Infirmary
Medical School: University of Glasgow


American Academy of Sleep Medicine, 1988-, National American Federation for Clinical Research, National American Society for Clinical Investigation, National American Thoracic Society, National Association of American Physicians, National European Sleep Research Society, International European Society for Clinical Respiratory Physiology, International Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Disorders Study Section, National Institutes of Health, National Royal College of Physicians and Surgeons of Glasgow, International Sleep and Biological Rhythms (official journal of the Japanese Society of Sleep Research and Asian Society of Sleep Research), International Sleep Research Society, National Society for Neuroscience, National

Hospital Affiliation

Dr. Pack is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Selected Publications:

Nikonova, E.V., Gilliland, J.D.A., Tanis, K.Q., Podtelezhnikov, A.A., Rigby, A.M., Galante, R.J., Finney, E.M., Stone, D.J., Renger, J.J., Pack, A.I. and Winrow, C.J.: Transcriptional profiling of cholinergic neurons from basal forebrain identifies changes in expression of genes between sleep and wake Sleep : 2017 (in press).

Matura, L.A., Fargo, J., Fritz, J.S., Smith, K.A., Vaidya, A., Pinder, D., Archer-Chicko, C., Palevsky, H.I., Pack, A.I., Sommers, M.S. and Kawut, S.M.: Slow-paced respiration therapy to treat symptoms in pulmonary arterial hypertension Heart Lung 46 (1): 7-13,2017.

Parthasarathy, S., Carskadon, M.A., Jean-Louis, G., Owens, J., Bramoweth, A., Combs, D., Hale, L., Harrison, E., Hart, C.N., Hasler, B.P., Honaker, S.M. Hertenstein, E., Kuna, S., Kushida, C., Levenson, J.C., Murray, C., Pack, A.I., Pillai, V., Pruiksma, K., Seixas, A., Strollo, P. Thosar, S.S., Williams, N. and Buysse, D.: Implementation of sleep and circadian science: recommendation from the Sleep Research Society and National Institutes of Health workshop Sleep 39 (12): 2061-2075,2016.

Modarres, M., Kuzma, N.N., Kretzmer, T., Pack, A.I., Lim, M.M.: EEG slow waves in traumatic brain injury: convergent findings in mouse and man Neurobiology of Sleep and Circadian Rhythms : 2016.

Lim, D.C., Brady, D.C., Soans, R., Kim, E.Y., Valverde, L., Keenan, B.T., Guo, X., Kim, W.Y., Park, M.J., Galante, R.J., Shackleford, J.A. and Pack, A.I.: Different cyclical intermittent hypoxia severities have different effects on hippocampal microvasculature Journal of Applied Physiology (1985) 121 (1): 78-88,2016.

Prasad, B., Usmani, S., Steffen, A.D., Van Dongen, H., Pack, F.M., Strakovsky, I., Staley, B., Dinges, D., Maislin, G., Pack, A.I. and Weaver, T.E.: Short-term variability in apnea-hypopnea index during extended home portable monitoring Journal of Clinical Sleep Medicine 12 (6): 855-863,2016.

Benotti, P., Wood, G.C., Argyropoulos, G., Pack, A., Keenan, B.T., Gao, X., Gerhard, G. and Still, C.: The impact of obstructive sleep apnea on nonalcoholic fatty liver disease in patients with severe obesity Obesity 24 (4): 871-877,2016.

Mullington, J.M., Abbott, .SM., Carroll, J.E., Dijk, D.J., Dinges, D.F., Gehrman, P.R., Ginsburg, G.S., Gozal, D., Haack, M., Lim, D.C., Macrea, M., Pack, A.I., Plante, D.T., Teske, J.A. and Zee, P.C.: Developing biomarker arrays predicting sleep and circadian-coupled risks to health Sleep 39 (4): 727-736,2016.

Magalang, U.J., Arnardottir, E.S., Chen, N.H., Cistulli, P.A., Gislason, T., Lim, D., Penzel, T., Schwab, R., Tufik, S. and Pack, A.I.: Agreement in the scoring of respiratory events among international sleep centers for home sleep testing Journal of Clinical Sleep Medicine 12 (1): 71-77,2016.

Bjornsdottir, E., Benediktsdottir, B., Pack, A.I., Arnardottir, E.S., Kuna, S.T., Gislason, T., Keenan, B.T., Maislin, G. and Sigurdsson, J.F.: The prevalence of depression among untreated obstructive sleep apnea patients using a standardized psychiatric interview Journal of Clinical Sleep Medicine 12 (1): 105-112,2016.

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Academic Contact Info

Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100

Philadelphia, PA 19104-3403
Phone: (215) 746-4806
Fax: (215) 746-4814
Patient appointments: 800-789-7366 (PENN)

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