PHILADELPHIA - The entire January issue of NeuroSignals is devoted to describing neurodegenerative disease research at the University of Pennsylvania School of Medicine and Health System (See www.karger.com/nsg for a Table of Contents and Abstracts).
“Neurodegenerative diseases are a public health problem and we are doing the basic and translational science to improve how we care for people with these diseases,” says John Trojanowski, MD, PhD, Director of the PENN Institute on Aging, who wrote the introductory paper, entitled, “PENN Neurodegenerative Disease Research – In The Spirit of Benjamin Franklin” for the issue.
The United States and nations across the globe are experiencing a seismic demographic shift due to the rapidly growing segment of the population 65 and older. These demographic changes reflect astonishing increases in life expectancy in the last millennium. For example, life expectancy has increased by about 27 years from 1900 to 1990, while a similar increase has occurred over the prior 5 millennia extending from the Bronze Age to 1900.
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Neuro-Signals Cover
January, 2008 |
“The good news about this longevity revolution is that Americans are not only living longer, but their disabilities continue to decline,” says Trojanowski. “However, if action is not taken immediately to plan for this demographic ‘sea change’, aging-related disorders like Alzheimer’s disease will have ominous consequences. Significantly, the costs to Medicare for treating Alzheimer’s and related dementias were $62 billion in 2000 but will increase to $1 trillion by 2050 if no effective treatments are developed.
“Although demography is the history of the future as written today, it is still possible to change the future now. For example, the burden of Alzheimer’s and its costs could be reduced by half in the coming years if interventions can be developed that delay the onset of the disease by five years. This realization motivated Penn scientists to pursue research to enhance healthy brain aging and reduce the burden of Alzheimer’s and other aging-related neurodegenerative diseases globally as well as nationally in our lifetime.”
This special issue of NeuroSignals provides an overview of these research programs at Penn:
John Q. Trojanowski
“PENN Neurodegenerative Disease Research – In The Spirit of Ben Franklin”
Christopher M. Clark, Christos Davatzikos, Ari Bortakur, Andrew Newberg, Susan Leight, Virginia M.-Y. Lee and John Q. Trojanowski
"Biomarkers for the Early Detection of Alzheimer’s Disease Pathology"
Applications of biomarkers in the real world--Use of biomarkers to make diagnoses for clinical trials.
Leslie Shaw
“Penn Biomarker Core of the Alzheimer Disease Neuroimaging Initiative”
Validation of chemical biomarkers and blood tests for Alzheimer’s
Rachel Goldmann Gross, Andrew Siderowf and Howard Hurtig
"Cognitive Impairment in Parkinson's Disease and Dementia with Lewy Bodies: A Spectrum of Disease"
Penn Udall Center is the only such center to look at cognitive impairment and Parkinson’s disease
Sarah M. Kranick and John E. Duda
“Olfactory Dysfunction in Parkinson’s Disease”
Early detection of Parkinson’s disease using a smell test
Benoit I. Giasson and Vivianna M. van Deerlin
“Mutations in LRRK2 as a Cause of Parkinson's DiseaseGenetics of Parkinson’s disease; LRRK2 is one of the most frequent mutations in this disease
Linda Kwong, Kunihiro Uryu, John Q. Trojanowski and Virginia M.-Y. Lee
“TDP-43 Proteinopathies: Neurodegenerative Protein Misfolding Diseases Without Amyloidosis”
Update on TDP-43 dementias in ALS and FTD
Aaron Gitler
“Beer and Bread to Brains and Beyond: Can Yeast Cells Teach us About Neurodegenerative Diseases?"
Using yeast models to study neuron diseases
James Shorter
“Hsp104, A Potential Weapon to Combat Diverse Neurodegenerative Disorders”
Heat shock proteins’ role in neuron diseases
Brett A. McCray and J. Paul Taylor
“The Role of Autophagy in Age-Related Neurodegeneration”
New pathways towards neurodegeneration
Lauren Elman, Leo McCluskey and Murray Grossman,
" Motor Neuron Disease and Frontotemporal Dementia: A Tale of Two Disorders Linked To TDP-43"
TDP-43 protein’s role in Lou Gehrig’s Disease
Jason Karlawish
“Measuring Decision Making Capacity in Cognitively Impaired Individuals”
Understanding how patients with neuron diseases can make informed decisions
Please contact Karen Kreeger if you would like more information any of these topics or would like to interview an investigator.
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Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, excellence in patient care, and community service. The organization consists of the University of Pennsylvania Health System and Penn’s Raymond and Ruth Perelman School of Medicine, founded in 1765 as the nation’s first medical school.
The Perelman School of Medicine is consistently among the nation's top recipients of funding from the National Institutes of Health, with $550 million awarded in the 2022 fiscal year. Home to a proud history of “firsts” in medicine, Penn Medicine teams have pioneered discoveries and innovations that have shaped modern medicine, including recent breakthroughs such as CAR T cell therapy for cancer and the mRNA technology used in COVID-19 vaccines.
The University of Pennsylvania Health System’s patient care facilities stretch from the Susquehanna River in Pennsylvania to the New Jersey shore. These include the Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Chester County Hospital, Lancaster General Health, Penn Medicine Princeton Health, and Pennsylvania Hospital—the nation’s first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.
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