PA) -- The question of whether post-menopausal women
should subscribe to Hormone Replacement Therapy (HRT)
is one of the most controversial issues in medicine
today, as scientists debate the benefits and risks associated
with taking estrogen over an extended period.
Now, research at the University of Pennsylvania School
of Medicine has revealed another possible plus for
HRT: Older patients taking estrogen may be significantly
less likely to suffer from two of the most common and
slow-to-heal wounds that afflict the elderly: pressure
ulcers (often described as "bed sores") and
venous leg ulcers.
The finding by David Margolis, MD, PhD, Associate
Professor of Dermatology at Penn, is published this
week in the journal The Lancet.
For the Study, Margolis reviewed the records of 44,195
"Our research indicates that patients receiving
HRT are around 35 percent less likely to develop a venous
leg ulcer or pressure ulcer, which we view as early
evidence that HRT may have a place in preventing chronic
wounds," said Margolis, who holds a secondary appointment
in Penn's Department of Biostatistics and Epidemiology.
The study was funded by the National Institute of Arthritis,
Muscular, Skeletal and Skin Diseases, which is part
of the National Institutes of Health.
Others who participated in the study are: Warren
Bilker, PhD, Assistant Professor of Biostatistics
and Epidemiology, and Jill Knauss, MA, in the
Department of Biostatistics and Epidemiology.
Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $5.3 billion enterprise.
The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 18 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $373 million awarded in the 2015 fiscal year.
The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center -- which are recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report -- Chester County Hospital; Lancaster General Health; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine.
Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2015, Penn Medicine provided $253.3 million to benefit our community.