The Arany lab studies cardiovascular metabolism, with a focus on the vasculature and striated muscles.
We take a multidisciplinary approach, spanning from molecular biology and numerous 'omic approaches to mouse models and human clinical studies. The objective is to make fundamental discoveries about cardiovascular metabolism and translate the findings to the clinic.
Examples of ongoing projects include:
- Understanding metabolism in the vasculature, using state-of-the-art metabolomic tools. Much is known of metabolism in cancer cells, and in parenchymal cells, but the role of metabolism in vascular cell biology has received little attention.
- CRISPR/Cas9 genome editing to identify novel genes that regulate vascular metabolism.
- Using the powerful metabolic regulator PGC-1alpha as a discovery platform to probe the regulation of metabolism and its coordination with vessel biology in striated muscles.
- Genetic studies of peripartum cardiomyopathy (PPCM), a disease that we now recognize as vascular in nature.
- Using mouse models to evaluate the role of the vasculature and metabolism in the development of, and protection from, muscle dystrophy, in particular Duchenne Muscle Dystrophy.
- Clinical echocardiographic and biomarker studies of cardiac function in preeclampsia, a disease that we now recognize as being significantly vasculotoxic to the heart.
Rich capillary networks (red) surrounding fat cells (green) in a white fat pad.
Live imaging of fatty acid uptake in mouse muscles.
Mighty mice. PGC-1a makes mitochondria, turns muscle red, and makes mice run further.
- Zoltan Arany, PI
- Jian Li, MD PhD
- Shogo Wada, PhD
- Atsushi Hoshino, MD PhD
- Cholsoon Jang
- Laura Liu
- Zhipeng Hu
visiting PhD student
- Boa Kim
- James Rhee, MD PhD,
- Mun Chun Chan, PhD,
- Arany Z.*, S.-Y. Foo, Y. Ma, J. Ruas, A. Bommi-Reddy, G. Girnun, M. Cooper, D. Laznik, J. Chinsomboon, S. Rangwala, K. H. Baek, A. Rosenzweig, and B.M. Spiegelman*. (2008) "HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α." Nature. 451: 1008-13. (editorials in NEJM, Dev Cell, and Science STK) PMID: 18288196. *co-corresponding authors.
- Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, Rowe G, Sawada N, Raghurama S, and Arany Z (2009) The Transcriptional Coactivator PGC-1α Mediates Exercise-Induced Angiogenesis in Skeletal Muscle. PNAS. 2009 Dec 15;106(50):21401-6. PMCID 2795492.
- Patten IS, Rana S, Shahul S, Rowe GC, Rhee JS, Jang C, Liu L, Hacker MR, Mitchell J, Mahmood F, Hess P, Bauersachs J, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac Angiogenic Imbalance Leads to Peripartum Cardiomyopathy. Nature. 2012 May 9;485(7398):333-8. PMCID 3356917 Featured in Institute of Medicine (IOM) report on Clinical and Translational Science Awards Program.
- Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wi Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z. (2013). PGC-1 coactivators regulate MITF and the tanning response. Molecular Cell. Jan 10;49(1):145-57. PMCID pending (editorials in Nature Reviews Cancer, and Pigment Cell & Melanoma Research).
- Haq R, Shoag S, Andreu-Perez P, Yokoyama S, Edelman H, Hurley AD, Nellore A, Wargo JA, Song JS, Fisher DE*, Arany Z*, Widlund HR*. Oncogenic BRAF regulates oxidative metabolism via PGC-1α and MITF. Cancer Cell. 2013 Mar 18; 23:302. PMCID pending (editorials in Nature Reviews Cancer, and Pigment Cell & Melanoma Research). *co-corresponding authors.
- Rowe GC, IS Patten, Z Zsengeller, R El-Khoury, M Okutsu, S Bampoh, N Koulisis, C Farrell, M Hirshman, Z Yan, L Goodyear, P Rustin, and Z Arany. Disconnecting mitochondrial content from respiratory chain capacity in PGC-1 deficient skeletal muscle. Cell Reports. 2013 May22. PMCID pending.
- Jang C, Arany Z. Metabolism: Sweet enticements to move. Nature. 2013 Aug 22;500(7463):409-11
- Chan MC, Rowe GC, Raghuram S, Patten IS, Arany Z. Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin. Skeletal Muscle. 2014 Jan 22;4(1):2.
- Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z. Endothelial PGC-1α mediates vascular dysfunction in diabetes. Cell Metabolism. 2014 Feb 4;19(2):246-582014 (Editor's choice Editorial in Science Signaling).
- Arany Z, Walker CM, Wang L. A 40-Year Old Woman with Dyspnea and Hypoxemia Post-Partum. New England Journal of Medicine. 2014 Jul 17;371(3):261-9.