Cardiovascular Research at Penn

Despite a nationwide downturn in funding from the National Institute of Health (NIH) over the past several years, support to cardiovascular research programs at Penn has grown rapidly.

Grants Awarded to Penn CVI Faculty Members

T32: NIH Institutional Research Training Grants

These NIH-sponsored training programs support the funding of postdoctoral fellows (MD, MD/PhD, PhD) devoted to training in basic or translational cardiovascular research.

Training Program in Cardiovascular Biology and Medicine

This training program supports six postdoctoral fellows (MD, MD/PhD, PhD) who devote two to three years to train in basic or translational cardiovascular research.
Grant Number: 5T32HL007843-15

Visit the NIH website for detailed project information

Multidisciplinary Training in Cardiovascular Biology

This training program supports six pre- and six postdoctoral trainees in interdisciplinary cardiovascular pathophysiology.
Grant Number: 5T32HL007954-12

Visit the NIH website for detailed project information

Multi-project Grants Funded for 2012-2013

iPS-derived hepatocytes for interrogation of lipid phenotypes

Principal Investigators: Daniel Rader, Edward Morrisey, and Stephen Duncan (Med. College of Wisconsin)

This project, which grew out of the Penn CVI-sponsored Complex Genetics Initiative, received the highest score of any project submitted to the NIH in response to a request for proposals focused in the area of stem cell/induced pluripotent stem cells and cardiovascular disease. This project will convert fibroblasts (skin cells) from patients with uncharacterized lipid disorders into liver cells to determine the cause of the lipid disorder which, in turn, may lead to new therapies.

Mid-Atlantic heart failure network

Principal Investigators: Thomas Cappola and Kenneth Margulies.

Penn was one of five programs chosen to join the NHLBI-supported Heart Failure network that directs all NIH-funded clinical trials in cardiology.

Integrative genomics of human heart failure

Principal Investigators: Thomas Cappola and Kenneth Margulies

Penn has the largest collection of explanted hearts from heart transplant patients in the world. This source of material will be utilized to identify genes associated with heart failure and progression of this common disease.

Epigenetic regulation of lung progenitor repair and regeneration

Principal Investigator: Edward Morrisey

This project will examine environmental factors that predispose patients to lung diseases including asthma, COPD, pulmonary fibrosis, and some forms of lung cancer (not associated with smoking).

Fractalkine in adipose inflammation and insulin resistance

Principal Investigator: Muredach Reilly

This project will determine the role of fractalkine, a new biomarker associated with obesity and inflammation, in predisposing patients to heart and vascular disease.

Glycomics of heart and lung disease in the genomic era

Principal Investigator: Muredach Reilly

Using unbiased mass-spectrometry approaches, we propose to define disease (myocardial infarction and acute lung injury) and cell (platelets and endothelium) specific ABO glycoproteomes in order to develop glycopeptides markers of risk and cross-organ, mechanisms-based phenotypes in heart and lung disease.

Lymph vessels in obesity and cardiovascular disease

Principal Investigator: Mark L. Kahn

The largely unexplored relationship between lymph vessels and obesity and cardiovascular disease is the focus of this network, which will study mouse models and human patients to determine the molecular and cellular mechanisms by which lymph vessel dysfunction leads to disease.

LeDucq Foundation transatlantic networks of excellence in cardiovascular disease

Principal Investigator: Daniel Rader

Directing cardiac myogenesis in development and adult progenitors: the role of Wnt and Notch

Principal Investigator: Jonathan Epstein

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