These NIH-sponsored training programs support the funding of postdoctoral fellows (MD, MD/PhD, PhD) devoted to training in basic or translational cardiovascular research.
This training program supports six postdoctoral fellows (MD, MD/PhD, PhD) who devote two to three years to train in basic or translational cardiovascular research.
Grant Number: 5T32HL007843-15
This training program supports six pre- and six postdoctoral trainees in interdisciplinary cardiovascular pathophysiology.
Grant Number: 5T32HL007954-12
iPS-derived hepatocytes for interrogation of lipid phenotypes
Principal Investigators: Daniel Rader, Edward Morrisey, and Stephen Duncan (Med. College of Wisconsin)
This project, which grew out of the Penn CVI-sponsored Complex Genetics Initiative, received the highest score of any project submitted to the NIH in response to a request for proposals focused in the area of stem cell/induced pluripotent stem cells and cardiovascular disease. This project will convert fibroblasts (skin cells) from patients with uncharacterized lipid disorders into liver cells to determine the cause of the lipid disorder which, in turn, may lead to new therapies.
Visit the NIH website for detailed project information
Mid-Atlantic heart failure network
Principal Investigators: Thomas Cappola and Kenneth Margulies.
Penn was one of five programs chosen to join the NHLBI-supported Heart Failure network that directs all NIH-funded clinical trials in cardiology.
Visit the NIH website for detailed project information
Integrative genomics of human heart failure
Principal Investigators: Thomas Cappola and Kenneth Margulies
Penn has the largest collection of explanted hearts from heart transplant patients in the world. This source of material will be utilized to identify genes associated with heart failure and progression of this common disease.
Visit the NIH website for detailed project information
Epigenetic regulation of lung progenitor repair and regeneration
Principal Investigator: Edward Morrisey
This project will examine environmental factors that predispose patients to lung diseases including asthma, COPD, pulmonary fibrosis, and some forms of lung cancer (not associated with smoking).
Visit the NIH website for detailed project information
Fractalkine in adipose inflammation and insulin resistance
Principal Investigator: Muredach Reilly
This project will determine the role of fractalkine, a new biomarker associated with obesity and inflammation, in predisposing patients to heart and vascular disease.
Visit the NIH website for detailed project information
Glycomics of heart and lung disease in the genomic era
Principal Investigator: Muredach Reilly
Using unbiased mass-spectrometry approaches, we propose to define disease (myocardial infarction and acute lung injury) and cell (platelets and endothelium) specific ABO glycoproteomes in order to develop glycopeptides markers of risk and cross-organ, mechanisms-based phenotypes in heart and lung disease.
Visit the NIH website for detailed project information
Lymph vessels in obesity and cardiovascular disease
Principal Investigator: Mark L. Kahn
The largely unexplored relationship between lymph vessels and obesity and cardiovascular disease is the focus of this network, which will study mouse models and human patients to determine the molecular and cellular mechanisms by which lymph vessel dysfunction leads to disease.
Visit Foundation Luducq for detailed project information
LeDucq Foundation transatlantic networks of excellence in cardiovascular disease
Principal Investigator: Daniel Rader
Visit Foundation Luducq for detailed project information
Directing cardiac myogenesis in development and adult progenitors: the role of Wnt and Notch
Principal Investigator: Jonathan Epstein
Visit the American Heart Association for detailed project information