Orthopaedic Medicine and Surgery Research and Clinical Trials

The McKay Orthopaedic Research Laboratory embodies the principles that guide orthopaedic research: interdisciplinary effort, common-use facilities, scientific collaboration, and collegial discussion. The McKay Lab occupies more than 15,000 square feet of space in the School of Medicine, and is populated by more than 100 research personnel and six principal investigators.

Penn Orthopaedics research foci include:

• Allotransplantation
• Bone metabolism and cancer-associated bone diseases
• Connective tissue extracellular matrix biophysics and cell biology
• Fibrodysplasia Ossificans Progressiva and other disorders of heterotopic ossification
• Genetic and cellular regulation of osteogenesis and chondrogenesis
• Intervertebral disc and soft tissue mechanics
• Mesenchymal stem cell maintenance and differentiation
• Musculoskeletal aging and disease
• Musculoskeletal tissue engineering
• Stem cell mechanobiology
• Tendon and ligament injury and repair