Douglas H. Smith serves as Director of the Center for Brain Injury and Repair (CBIR) and is the Robert A. Groff Endowed Professor and Vice Chairman for Research and Education in Neurosurgery at the University of Pennsylvania. Penn's multi disciplined CBIR includes over 25 principal investigators and their laboratory staff collectively studying mechanisms, diagnosis and potential treatments of traumatic brain injury.
Dr. Smith is also director of a multi-center U.S. National Institutes of Health (NIH) program grant on mild traumatic brain injury and oversees an NIH brain injury training grant. Over the last 20 years, Dr. Smith has devoted his full-time efforts to neurotrauma research following completion of fellowships in both molecular biology and neurotrauma at the University of Connecticut. His laboratory investigates the effects of mechanical stretch of axons that results in either damage or growth. He has found that rapid stretch during brain trauma selectively injures axons in the white matter. In turn, aberrant accumulation of proteins in the damaged axons can lead to pathologic changes similar to those found in Alzheimer's disease. In addition, Dr. Smith's laboratory has also recently discovered that slow continuous stretching of axon tracts in culture can stimulate enormous growth, creating transplantable living nervous tissue constructs. These tissue engineered constructs have shown promise for repairing large lesions in the nervous system. These collective efforts have resulted in over 150 published reports.
Abigail completed her undergraduate degree in bioengineering with a focus in tissue engineering and regenerative medicine. She is interested in observing the degeneration of axons as well as studying blood biomarkers following traumatic brain injury and spinal cord injury. Abigail enjoys the opportunity to combine medicine and engineering in a place that encourages innovation.
Arka is an M.D./M.T.R. Candidate at the University of Pennsylvania's Perelman School of Medicine who completed a research year out in the Smith Lab. His research interests include multimodal neuroimaging, connectomics, and computational modeling of traumatic brain injury and translating these findings to the clinical setting. Outside of lab, Arka enjoys hiking and multiple TV series.
Jake began working in the Smith lab in June 2017 as a research specialist after earning a BSE in bioengineering and a chemistry minor from Penn. He worked on a drug release mechanism for capsule endoscopy as part of his senior design project. Jake’s research interests include evaluating mechanisms of axonal degeneration and repair following traumatic brain injury.
Jean-Pierre received his PhD in Biomedical Engineering from Rutgers University, his MS in Biomedical Engineering from Drexel University and his BSc in Aeronautical Engineering from the University of Witwatersrand in South Africa. His research interests involve investigating the increased risk of dementia following traumatic brain injury events.
John is an MD Candidate at the University of Pennsylvania's Perelman School of Medicine. His research interests are focused on underlying mechanisms of axonal injury and the long-term neurodegenerative sequelae of traumatic brain injury. John also serves a leadership role in the School of Medicine's Langfitt Neurosurgical Society, helping connect students with research mentors. Prior to his arrival at Penn, John attended the Johns Hopkins University where he studied neuroscience, investigated rodent models of TBI and captained the Blue Jays football team.
Jose L. Pascual, MD, PhD, FRCS, FACS, NCC (UCNS) Dr. Pascual is an Associate Professor of Surgery in the Department of Trauma, Emergency Surgery, and Surgical & NeuroCritical Care at both the University of Pennsylvania Hospital and Penn Presbyterian Medical Center. He is the director of Office of Life Support Education, Patient Safety Officer at the University of Pennsylvania Hospital and Clinical Associate at the University Of Pennsylvania School Of Nursing. He received his MD degree at University of Ottawa in 1996 and his PhD at McGill University in 2005. His thesis investigated the salutary effects of immunemodulating fluids in shock. Dr. Pascual research interests include Traumatic Brain Injury, shock and ICU education through simulation and patient safety initiatives. His TBI laboratory studies immune responses to injury through intravital microscopy of the cerebral microcirculation investigating the role of the neutrophil in injury and shock.
Justin joined the Smith Neurotrauma Lab in 2017 as a Research Specialist after earning a BS in Biomedical Engineering from Drexel University. Justin is interested in neuronal repair following injury. He hopes to pursue a PhD in Biomedical Engineering in the future.
Kevin is a MSE candidate in Bioenegineering at Penn, having received his BS in Biomedical Engineering at Rutgers, New Brunswick. His research background and interests are in scaffold design and biomaterials in regards to tissue engineering, and is currently helping Dr. Smith investigate a possible means of synaptogenesis.
In May 2017, Natalie received a BS in chemistry from Haverford College with a concentration in biochemistry. Her undergraduate thesis involved working with peptide hydrogels. In August 2017, Natalie started a master's program in bioengineering at the University of Pennsylvania. She is currently working in the Smith Lab on her master's thesis, seeking to better understand traumatic brain injury using induced pluripotent stem cells.
Dr. Acharya obtained his PhD in Cell and Molecular Biology from Rutgers University (formerly UMDNJ). His dissertation studies were aimed at understanding the pathophysiology of Alzheimer's disease (AD) and developing blood-based biomarkers for AD diagnosis. He holds a Master's degree in Medical Biochemistry and a Bachelor's degree in Medical Laboratory Technology. Dr. Acharya joined the Smith lab in 2016 and is spearheading a project investigating the formation of intricate neuronal pathways in the developing brain. He is also part of the team investigating the pathophysiology of Traumatic Brain Injury using the Smith Lab's rotational acceleration injury model.
Dr. Swanson is a Physiatrist (Rehab Doctor) specializing in Neurorehabilitation, with a clinical focus on Traumatic Brain Injury. Broadly speaking, Dr. Swanson's research interests surround the mechanisms of secondary neurodegeneration following TBI, and the development of accurate diagnostic and prognostic biomarkers for post-TBI neurodegeneration. Dr. Swanson joined the lab in 2016 after receiving funding (K-award) through the Rehabilitation Medical Scientist Training Program (RMSTP). His RMSTP research aims to investigate the role of IgG-autoantibodies in secondary neuronal injury following TBI. Further, Dr. Swanson will be examining the utility of IgG-autoantibodies to serve as novel biomarkers for advanced TBI diagnostic and prognostic testing.
Syed is a medical graduate from Pakistan and a member of Dr. Jose Pascual’s lab. His project focuses on the comparison of anti-inflammatory effects of heparinoids, noval oral anti-coagulants (NOACs), and anti-platelet drugs in a traumatic brain injury (TBI) setting. He utilizes flow cytometry, pial intravital microscopy, ELISA, and histology to quantify host tissue damage, neutrophil surface receptor expression, rolling and adhesion in a murine model of TBI.
Yujin is a visiting scholar from Japan, with 10 years of clinical experience as gastric surgeon. He is interested in the effects of heparinoids on traumatic brain injury (TBI) in multitrauma cases. His work in the lab focuses on anti-inflammatory properties of enoxaparin on secondary brain injury following TBI, in the presence of a concomitant long bone fracture. Evaluating in vivo through intravital microscopy the real time microcirculation of pia on rodent brains..