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A research study conducted by "The Strategies to Innovate Emergency Care Clinical Trials Network (SIREN)"
BOOST3 is a research study to learn if either of two strategies for monitoring and treating patients with Traumatic Brain Injury (TBI) in the intensive care unit (ICU) is more likely to help them get better. Both of these alternative strategies are used in standard care. It is unknown if one is more effective than the other. In one strategy doctors concentrate only on preventing high ICP (intracranial pressure) caused by a swollen brain. In the other strategy doctors try to prevent high ICP, and also try to prevent low PbtO2 (brain oxygen). It is unknown if measuring and treating low brain oxygen is more effective, less effective, or the same as monitoring and treating high brain pressure alone. The results of this study will help doctors discover if one of these methods is more safe and effective.