Sharing the outcomes of our research with the academic community has long been a source of pride at Penn Medicine’s Department of Radiology. The Department publishes numerous articles in prominent scientific journals (see below) as well as serving on a number of their editorial boards.
Selected Publications 2020-2021
Radiology MRI scientists, psychiatry and psychology investigators collaborated to provide this unique connection between behavior and brain glutamine levels measured by advanced high-field MR.
Sydnor VJ, Larsen B, Kohler C, Crow AJD, Rush SL, Calkins ME, et al. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study. Mol Psychiatry. 2021. pubmed.ncbi.nlm.nih.gov/33479514/
The Wehrli Lab, working with investigators in the Sleep Center, used novel on-invasive MR measures of regional oxygen consumption to study changes occurring during sleep.
Caporale A, Lee H, Lei H, Rao H, Langham MC, Detre JA, et al. Cerebral metabolic rate of oxygen during transition from wakefulness to sleep measured with high temporal resolution OxFlow MRI with concurrent EEG. J Cereb Blood Flow Metab. 2021;41(4):780-92. pubmed.ncbi.nlm.nih.gov/32538283/
Dr. Peter Noël, a new faculty member and CT physics expert, showed the advantage of adding advanced CT methods to PET/CT.
Shapira N, Scheuermann J, Perkins AE, Kim J, Liu LP, Karp JS, et al. Quantitative positron emission tomography imaging in the presence of iodinated contrast media using electron density quantifications from dual-energy computed tomography. Med Phys. 2021;48(1):273-86. pubmed.ncbi.nlm.nih.gov/33170953/
Penn Radiology led an imaging core lab for the SPRINT study, with findings that led to new insight into the association of blood pressure and AD.
Nasrallah IM, Gaussoin SA, Pomponio R, Dolui S, Erus G, Wright CB, et al. Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial. JAMA Neurol. 2021. pubmed.ncbi.nlm.nih.gov/33683313/
Penn Radiology faculty played key roles in the creation of a national database for COVID-19 related images.
Tsai EB, Simpson S, Lungren MP, Hershman M, Roshkovan L, Colak E, et al. The RSNA International COVID-19 Open Radiology Database (RICORD). Radiology. 2021;299(1):E204-E13. pubmed.ncbi.nlm.nih.gov/33399506/
This Penn Radiology-led collaboration with the Abramson Cancer Center Breast Cancer Program and Cancer Biology demonstrated the ability of a novel PARP tracer, invented by another Penn faculty member (Robert Mach), to measure PARP inhibitor drug targeting in breast cancer.
McDonald ES, Pantel AR, Shah PD, Farwell MD, Clark AS, Doot RK, et al. In vivo visualization of PARP inhibitor pharmacodynamics. JCI Insight. 2021;6(8). pubmed.ncbi.nlm.nih.gov/33884961/
Collaborations between the Penn Radiochemistry Program and investigators at Princeton led to novel organic synthesis methods for PET ligands.
Pipal RW, Stout KT, Musacchio PZ, Ren S, Graham TJA, Verhoog S, et al. Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery. Nature. 2021;589(7843):542-7. pubmed.ncbi.nlm.nih.gov/33238289/
Work led by John Lee of Neurosurgery working with Penn Radiology's Delikatny Lab led to advances in glioma surgery outcomes guided by optical molecular probes.
Teng CW, Cho SS, Singh Y, De Ravin E, Somers K, Buch L, et al. Second window ICG predicts gross-total resection and progression-free survival during brain metastasis surgery. J Neurosurg. 2021:1-10. pubmed.ncbi.nlm.nih.gov/33652417/
A trainee in the Witschey Lab, worked with investigators in cardiology to demonstrate the value of MR-based iron imaging, developed by Dr. Witschey for cardiac re-perfusion imaging.
Moon BF, Iyer SK, Hwuang E, Solomon MP, Hall AT, Kumar R, et al. Iron imaging in myocardial infarction reperfusion injury. Nat Commun. 2020;11(1):3273. www.nature.com/articles/s41467-020-16923-0
A junior CE track member described first-in-human studies in the Penn whole-body tomograph, one of two devices of its kind in the U.S., developed by a Penn Radiology group led by Joel Karp.
Pantel AR, Viswanath V, Daube-Witherspoon ME, Dubroff JG, Muehllehner G, Parma MJ, et al. PennPET Explorer: Human Imaging on a Whole-Body Imager. J Nucl Med. 2020;61(1):144-51. pubmed.ncbi.nlm.nih.gov/31562224/
Collaboration between Penn Memory Center and Radiology leaders in image analytics results in new insight into patterns of early atrophy in AD.
Xie L, Wisse LEM, Das SR, Vergnet N, Dong M, Ittyerah R, et al. Longitudinal atrophy in early Braak regions in preclinical Alzheimer's disease. Hum Brain Mapp. 2020;41(16):4704-17. pubmed.ncbi.nlm.nih.gov/32845545/
A pioneering new approach from the PIGI Lab using metabolic imaging and CRISPR-based screening to identify therapeutic targets in HCC.
Perkons NR, Johnson O, Pilla G, Profka E, Mercadante M, Ackerman D, et al. Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer. Clin Cancer Res. 2020;26(17):4581-9. clincancerres.aacrjournals.org/content/26/17/4581
Novel molecular imaging methods for tracking CAR T cells developed by two collaborating Penn junior faculty members (Sellmyer and Farwell) demonstrate great promise in early studies.
Sellmyer MA, Richman SA, Lohith K, Hou C, Weng CC, Mach RH, et al. Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene. Mol Ther. 2020;28(1):42-51. pubmed.ncbi.nlm.nih.gov/31668558/
The Pryma Lab in Radiology and the Maris Lab at CHOP leveraged the Mach PARP platform for novel therapeutics for neuroblastoma.
Lee H, Riad A, Martorano P, Mansfield A, Samanta M, Batra V, et al. PARP-1-Targeted Auger Emitters Display High-LET Cytotoxic Properties In Vitro but Show Limited Therapeutic Utility in Solid Tumor Models of Human Neuroblastoma. J Nucl Med. 2020;61(6):850-6. pubmed.ncbi.nlm.nih.gov/31676730/
This paper from the Radiology Thoracic Section was the first to establish criteria for COVID-19 diagnosis by CT.
Simpson S, Kay FU, Abbara S, Bhalla S, Chung JH, Chung M, et al. Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA - Secondary Publication. J Thorac Imaging. 2020;35(4):219-27. pubs.rsna.org/doi/10.1148/ryct.2020200152
Penn Radiology's Breast Imaging Section carried out an early test of a novel approach to MRI that led to a national trial of this approach.
Weinstein SP, Korhonen K, Cirelli C, Schnall MD, McDonald ES, Pantel AR, et al. Abbreviated Breast Magnetic Resonance Imaging for Supplemental Screening of Women With Dense Breasts and Average Risk. J Clin Oncol. 2020;38(33):3874-82. pubmed.ncbi.nlm.nih.gov/32931396/
This effort led by Radiology Instructor, Spyros Bakas, demonstrated the value of a new method for data sharing and analysis that is now part of larger trials and partnerships with industry.
Bakas S, Shukla G, Akbari H, Erus G, Sotiras A, Rathore S, et al. Integrative radiomic analysis for pre-surgical prognostic stratification of glioblastoma patients: from advanced to basic MRI protocols. Proc SPIE Int Soc Opt Eng. 2020;11315. pubmed.ncbi.nlm.nih.gov/33746333/