Department of Radiology

Penn has a long history of development of nuclear medicine instrumentation in both SPECT and PET dating back to the pioneering work of David Kuhl, MD, in the 1970s. The Nuclear Medicine Physics and Instrumentation Research Group strives to continue this tradition in an environment that encourages the development of new technology and the collaboration between basic scientists and clinicians to evaluate new instruments and optimize their use for new applications in both clinical and pre-clinical (animal) imaging situations.

Our lab includes equipment to build, test and characterize detectors for PET imaging. In addition, the laboratory operates a cluster of high-powered Linux computers, which reconstruct, process, and analyze imaging data. Most recently, faculty has focused on the development of time-of-flight technology, which increases the signal-to-noise of reconstructed images for whole-body studies. The faculty also conducts research on SPECT imaging with an emphasis on applications to small animal and brain imaging.

The Nuclear Medicine Physics and Instrumentation research group additionally oversees the operation of the cyclotron and imaging probe synthesis facilities.


The Physics and Instrumentation Group is located in Blockley Hall, 4th Floor.

The PET Center is located in the Silverstein Pavilion of the Hospital of the University of Pennsylvania (HUP).

  • Meet Our Team

    Meet the members of the Nuclear Medicine Physics and Instrumentation Group.

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