Department of Radiology

Selected 2015-2016 Publications

Nath K, Guo L, Nancolas B, Nelson DS, Shestov AA, Lee SC, Roman J, Zhou R, Leeper DB, Halestrap AP, Blair IA, Glickson JD.: Mechanism of antineoplastic activity of lonidamine. Biochimica et Biophysica Acta. 1866(2): 151-162, 2016.

Nancolas B, Guo L, Zhou R, Nath K, Nelson DS, Leeper DB, Blair IA, Glickson JD, Halestrap AP.: The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. The Biochemical Journal 473(7): 929-936, 2016. PMCID: PMC4814305.

Liu T, Nath K, Liu W, Zhou R, Chen IW.: A study of the relationship of metabolic MR parameters to estrogen dependence in breast cancer xenografts. NMR in Biomedicine. 28(9): 1087-1096, 2015. PMCID: PMC4537822.

Liu T, Choi H, Zhou R*, Chen I*. RES Blockade: A Strategy for Boosting Efficiency of Nanoparticle Drug. NanoToday  2015; 10:11-21 * co-corresponding authors

Nath K, Nelson DS, Heitjan DF, Leeper DB, Zhou R, Glickson JD. Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin. NMR Biomed 2015;28(3):281-290.

Nath K, Nelson DS, Heitjan DF, Zhou R, Leeper DB, Glickson JD. Effects of hyperglycemia on lonidamine-induced acidification and de-energization of human melanoma xenografts and sensitization to melphalan. NMR Biomed 2015;28(3):395-403.

Selected 2013-2014 Publications

Liu T, Choi H, Zhou R, Chen IW: Quantitative evaluation of the reticuloendothelial system function with dynamic MRI. PLOS ONE 2014, 9:e103576.

Xu HN, Zhou R, Moon L, Feng M, Li LZ: 3D Imaging of The Mitochondrial Redox State of Rat Hearts Under Normal and Fasting Conditions. J Innov Opt Health Sci. 7(2): 1350045, March 2014 PMCID: PMC4048726.

Zhang H, Zhou R. Noninvasive imaging of myocardial blood flow recovery in response to stem cell intervention. Methods Mol Biol 2013;1052:89-99.

Paudyal R, Poptani H, Cai K, Zhou R, Glickson JD. Impact of transvascular and cellular-interstitial water exchange on dynamic contrast-enhanced magnetic resonance imaging estimates of blood to tissue transfer constant and blood plasma volume. J Magn Reson Imaging 2013;37:435-444.

Nath K, Nelson DS, Ho AM, Lee S-C, Darpolor MM, Pickup S, Zhou R, Heitjan DF, Leeper DB, Glickson JD. 31P and 1H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan. NMR in Biomedicine 2013;26:98-105.

Selected 2012 Publications

Lowell AN, Qiao H, Liu T, Ishikawa T, Zhang H, Oriana S, Wang M, Ricciotti E, FitzGerald GA, Yamakoshi Y* and Zhou R*. Functionalized Low-Density Lipoprotein Nanoparticles for in Vivo Enhancement of Atherosclerosis on Magnetic Resonance Images. Bioconjugate Chemistry 2012; 23: 2313-2319 (* co-corresponding author).

Zhang H, Qiao H, Frank RS, Huang B, Propert KJ, Margulies S, Ferrari VA, Epstein JA, Zhou R. Spin-Labeling Magnetic Resonance Imaging Detects Increased Myocardial Blood Flow After Endothelial Cell Transplantation in the Infarcted Heart. Circulation: Cardiovascular Imaging. 2012;5:210-217.

Zhang H, Qiao H, Ferrari VA, Zhou R. Imaging Cell Therapy for Myocardial Regeneration. Current Cardiovascular Imaging Reports. 2012; 5(1):53-59.

Selected 2011 Publications

Ferrari VA, Witschey WRT, Zhou R. CMR Assessment of Myocardial Fibrosis- Honing New Clinical Tools (editorial), Circulation Cardiovascular Imaging. 2011;4(6):604-6.

Boheler KR, Joodi RN, Qiao H, Juhasz O, Urick AL, Chuppa SL, Gundry RL, Wersto RP, Zhou R. Embryonic Stem Cell-derived Cardiomyocyte Heterogeneity and the Isolation of Immature and Committed Cells for Cardiac Remodeling and Regeneration. Stem Cells International. 2011; www.hindawi.com/journals/sci/aip/214203/.

Yamakoshi Y, Qiao H, Lowell AN, Woods M, Paulose B, Nakao Y, Zhang H, Liu T, Lund-Katz S, Zhou R. LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models. Chem Commun (Camb). 2011;47:8835-7.

Li LZ, Zhou R, Leeper DB, Glickson JD. (31)P-MRS studies of melanoma xenografts with different metastatic potential. Adv Exp Med Biol. 2011;701:69-73.

Qiao H, Zhang H, Yamanaka S, Patel VV, Petrenko NB, Huang B, Muenz LR, Ferrari VA, Boheler KR and Zhou R: Long-term Improvement in Post-Infarct Left Ventricular Global and Regional Contractile Function Mediated by Embryonic Stem Cell-Derived Cardiomyocytes. Circulation: Cardiovascular Imaging 2011; 4(1): 33-41.

Zhang H, Qiao H, Bakken A, Gao F, Huang B, Liu YY, El-Deiry W, Ferrari VA, and Zhou R: Utility of Dual-modality Bioluminescence and MRI in Monitoring Stem Cell Survival and Impact on Post Myocardial Infarct Remodeling Academic Radiology 2011; 18(1): 3-12.

Selected 2010 Publications

Qiao H, Zhang H, Yamanaka S, Patel VV, Petrenko NB, Huang B, Muenz LR, Ferrari VA, Boheler KR and Zhou R: Long-term Improvement in Post-Infarct Left Ventricular Global and Regional Contractile Function Mediated by Embryonic Stem Cell-Derived Cardiomyocytes. Circulation: Cardiovascular Imaging 2010 Nov.

Zhou R, Idiyatullin D, Moeller S, Corum C, Zhang H, Qiao H, Zhong J, Garwood M. SWIFT Detection of SPIO Labeled Stem Cells Grafted in the Myocardium. Magnetic Resonance in Medicine 2010 May; 63: 1154-1161.

Zhou R, Mazurchuk RV, Tamburlin JH, Harrold JM, Mager DE, Straubinger RM. Differential pharmacodynamic effects of paclitaxel formulations in an intracranial rat brain tumor model. J Pharmacol Exp Ther 2010 Feb; 332: 479-488.

Books Published in 2010

Zhou R and Qiao H: Chapter 15 Radionuclide Cell Labeling Method. Stem Cell Labeling for Delivery and Tracking Using Non-invasive Imaging, Kraitchman DL and Wu JC (eds.). Taylor& Francis /CRC Press, 2010.

Selected 2009 Publications

Llano R, Epstein S, Zhou R, Zhang H, Hamamdzic D, Keane MG, Freyman T, Wilensky RL, Intracoronary delivery of mesenchymal stem cells at high flow rates after myocardial infarction improves distal coronary blood flow and decreases mortality in pigs. Catheter Cardiovasc Interv. 2009; 73(2): 251-7.

Wang D, Patel VV, Ricciotti E, Zhou R, Levin MD, Gao E, Yu Z, Ferrari VA, Lu M and Fitzgerald GA, Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci USA 2009; 106(18): 7548-52.

Li LZ*, Zhou R*, Xu HN, Moon L, Zhong T, Kim EJ, Qiao H, Reddy R, Leeper D, Chance B, Glickson JD. Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential. Proc Natl Acad Sci USA 2009; 106(16): 6608-13. * equal contribution first author

Qiao H, Surti S, Choi SR, Raju K, Zhang H, Ponde DE, Kung HF, Karp JS, Zhou R. Death and proliferation time course of stem cells transplanted in the myocardium. Molecular Imaging and Biology 2009;11: 408-414.

Qiao H, Zhang H, Zheng Y, Ponde DE, Shen D, Gao F, Bakken AB, Schmitz A, Kung HF, Ferrari VA, Zhou R. Embryonic Stem Cell Grafting in Normal and Infarcted Myocardium: Serial Assessment with MR Imaging and PET Dual Detection. Radiology 2009; 250(3):821-829.

Selected 2008 Publications

Glickson JD, Lund-Katz S, Zhou R, Choi H, Chen I, Li H, Corbin I, V. PA, Cao W, Song L, Qi C, Marotta D, Nelson DS, Chen J, Chance B, and Zheng G. Lipoprotein Nanoplatform for Targeted Delivery of Diagnostic and Therapeutic Agents. Molecular Imaging. 2008; 7: 101-110.

Plossl K, Chandra R, Qu W, Lieberman BP, Kung MP, Zhou R, Huang B, and Kung HF. A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent. Nucl Med Biol. 2008; 35: 83-90.

Huang MQ, Pickup S, Nelson DS, Qiao H, Xu HN, Li LZ, Zhou R, Delikatny EJ, Poptani H, Glickson JD. Monitoring response to chemotherapy of non-Hodgkin's lymphoma xenografts by T(2)-weighted and diffusion-weighted MRI. NMR Biomed. 2008;21(10):1021-1029.

Selected 2007 Publications

Shen D, Liu D, Cao Z, Acton PD, Zhou R. Co-registration of MR and SPECT images for non-invasive localization of stem cells grafted in the infarcted rat myocardium. Molecular Imaging and Biology. 2007; 9: 24-31.

Zhang Z, Tang W, Zhou R, Wei Z, Patel AM, Bennett J, Strauss III JF. Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins. Cell Motility and the Cytoskeleton. 2007; 64: 360-76.

Li LZJ, Zhou R, Zhong T, Moon L, Kim EJ, Qiao H, Pickup S, Hendrix MJ, Leeper D, Chance B, Glickson JD: Predicting melanoma metastatic potential by optical and magnetic resonance imaging. Adv Exp Med Biol. 2007; 599: 67-78.

Zhang Z, Tang W, Zhou R, Wei Z, Patel AM, Bennett J, Strauss III JF. Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins. Cell Motility and the Cytoskeleton. 2007; 64: 360-76.

Li LZJ, Zhou R, Zhong T, Moon L, Kim EJ, Qiao H, Pickup S, Hendrix MJ, Leeper D, Chance B, Glickson JD: Predicting melanoma metastatic potential by optical and magnetic resonance imaging. Adv Exp Med Biol. 2007; 599: 67-78.

Selected 2006 Publications

Zhou R, Acton PD, Ferrari VA. Imaging Stem Cells Implanted in Infarcted Myocardium. Journal of American College of Cardiology. 2006; 48: 2094-2106.

Thomas D, Dumont C, Pickup S, Misselwitz B, Zhou R, Horowitz J, Ferrari V. T1-weighted cine FLASH is superior to IR imaging of post-infarction myocardial viability at 4.7T. J Cardiovasc Magnetic Resonance. 2006; 8(2):345-52.

Corbin IR, Li H, Chen J, Lund-Katz S, Zhou R, Glickson JD, et al. Low-density lipoprotein nanoparticles as magnetic resonance imaging contrast agents. Neoplasia. 2006;8(6):488-98.

Acton PD, Thomas D, Zhou R. Quantitative imaging of myocardial infarct in rats with high resolution pinhole SPECT. Int J Cardiovasc Imaging 2006; 22(3-4):429-434.

Selected 2005 Publications

Zhou R, Thomas DH, Qiao H, Bal HS, Choi S-R, Alavi A, et al. In Vivo Detection of Stem Cells Grafted in Infarcted Rat Myocardium. J Nucl Med 2005; 46(5):816-822.

Thomas D, Pickup S, Zhou R, Glickson J, Ferrari VA. [Comparison of homogenous strain-analysis with wall thickening for the assessment of regional myocardial function]. Rofo. 2005; 177(7):975-85.

Li Z, Qiao H, Lebherz C, Choi SR, Zhou X, Gao G, Kung HF, Rader DJ, Wilson JM, Glickson JD, Zhou R. Creatine kinase, a magnetic resonance-detectable marker gene for quantification of liver-directed gene transfer. Human Gene Therapy. 2005; 16 (12):1429-38.

Levy RJ, Piel DA, Acton PD, Zhou R, Ferrari VA, Karp JS, et al. Evidence of myocardial hibernation in the septic heart. Crit Care Med. 2005; 33(12): 2752-6.

Kostetskii I, Li J, Xiong Y, Zhou R, Ferrari VA, Patel VV, et al. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circulation Res. 2005; 96(3):346-54.

Ismat FA, Zhang M, Kook H, Huang B, Zhou R, Ferrari VA, et al. Homeobox Protein Hop Functions in the Adult Cardiac Conduction System. Circulation Res. 2005; 96(8):898-903.

Acton PD, Zhou R. Imaging reporter genes for cell tracking with PET and SPECT. Q J Nucl Med Mol Imaging. 2005; 49(4):349-60.

Selected 2004 Publications and earlier

2004

Zhou R, Pickup S, Yankeelov TE, Springer CS, Jr., Glickson JD. Simultaneous measurement of arterial input function and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchange. Magnetic Resonance in Medicine 2004; 52(2):248-57.

Thomas DH, Ferrari VA, Janik M, Kim DH, Pickup S, Glickson JD, Zhou R. Quantitative assessment of regional myocardial function in a rat model of myocardial infarction using tagged MRI. MAGMA. 2004; 17:179-187.

Straubinger RM, Arnold RD, Zhou R, Mazurchuk R, Slack JE. Antivascular and antitumor activities of liposome-associated drugs. Anticancer Res. 2004; 24(2A):397-404.

Li H, Zhang Z, Blessington D, Nelson DS, Zhou R, Lund-Katz S, et al. Carbocyanine labeled LDL for optical imaging of tumors. Acad Radiol. 2004; 11(6):669-77.

Li H, Gray BD, Corbin I, Lebherz C, Choi H, Lund-Katz S, Wilson JM, Glickson JD and Zhou R. MR and fluorescent imaging of low-density lipoprotein receptors. Acad Radiol. 2004; 11(11): 1251-9.

Gruber PJ, Li Z, Li H, Worrad D, Huang B, Abdullah I, Wang W, El-Deiry W, Ferrari VA, Zhou R. In vivo imaging of mlc2v-luciferase, a cardiac-specific reporter gene expression in mice. Acad Radiol. 2004; 11(9):1022-8.

Choi H, Choi SR, Zhou R, Kung HF, Chen IW. Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery. Acad Radiol. 2004; 11(9): 996-1004

Canter RJ, Zhou R, Kesmodel SB, Zhang Y, Heitjan DF, Glickson JD, et al. Metaiodobenzylguanidine and hyperglycemia augment tumor response to isolated limb perfusion in a rodent model of human melanoma. Ann Surg Oncol. 2004; 11(3):265-73.

2003

Zhou R, Pickup S, Glickson JD, Scott C, Ferrari VA. Assessment of Global and Regional Myocardial Function in the Mouse Using Cine- and Tagged MRI. Magnetic Resonance in Medicine 2003;49:760-764.

Pickup S, Zhou R, Glickson J. MRI estimation of the arterial input function in mice. Acad Radiol. 2003; 10(9):963-8.

Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, Epstein JA. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J. Clin. Invest. 2003; 112(6): 863-871.

Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, et al. Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 2003; 299 (5604): 247-51.

2002

Zhou R, Mazurchuk R, Straubinger RM. Antivasculature effects of doxorubicin-containing liposomes in an intracranial rat brain tumor model. Cancer Res. 2002; 62(9):2561-6.

2001

Zhou R, Bansal N, Leeper DB, Pickup S, Glickson JD. Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport. Acad Radiol. 2001; 8(7):571-82.

Auricchio A, Zhou R, Wilson JM, Glickson JD. In vivo detection of gene expression in liver by 31P nuclear magnetic resonance spectroscopy employing creatine kinase as a marker gene. Proc Natl Acad Sci USA 2001; 98(9):5205-10.

2000

Zhou R, Bansal N, Leeper DB, Glickson JD. Intracellular acidification of human melanoma xenografts by the respiratory inhibitor m-iodobenzylguanidine plus hyperglycemia: a 31P magnetic resonance spectroscopy study. Cancer Res. 2000; 60(13):3532-6.

1999

Zhou R, Balasubramanian SV, Kahl SB, Straubinger RM. Biopharmaceutics of boronated radiosensitizers: liposomal formulation of MnBOPP (manganese chelate of 2,4-(alpha, beta-dihydroxyethyl) deuteroporphyrin IX) and comparative toxicity in mice. J Pharm Sci. 1999; 88(9):912-7.

Mazurchuk R, Zhou R, Straubinger RM, Chau RI, Grossman Z. Functional magnetic resonance (fMR) imaging of a rat brain tumor model: implications for evaluation of tumor microvasculature and therapeutic response. Magnetic Resonance Imaging. 1999; 17(4):537-48.

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