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Trial Contacts

Primary Investigator: Gary Falk, MD
Research Coordinator: Maureen DeMarshall, RN
demarshm@mail.med.upenn.edu
215-349-8546

Studies

Application of the Microbiome and Microenvironment to Novel Non-Endoscopic Screening and Surveillance in Barrett’s Esophagus

Cross-sectional study of patients with BE, with or without associated dysplasia or adenocarcinoma, and controls without BE.

  • Aim 1. To assess the relationship between the microbiome and tissue inflammation in Barrett’s progression to EAC.
  • Aim 2. To determine how bile acid composition impacts the microbiome and tissue inflammation in Barrett’s esophagus.
  • Aim 3. To develop a non-endoscopic, biologically-based screening and surveillance strategy for Barrett’s esophagus.

Familial Barrett's Esophagus

BETRNet funded study

A collaborative multi-center study evaluating the genetic and environmental determinants of Barrett’s esophagus and esophageal adenocarcinoma.

The aim is to define the epidemiology and genetics of Barrett’s esophagus and esophageal cancer in families affected with Barrett’s esophagus and esophageal adenocarcinoma. Barrett’s esophagus and esophageal cancer occur at a younger age in these families suggesting that familial Barrett’s esophagus is a genetically inherited disease.

Criteria

Inclusion/Exclusion Criteria

Eligible cases will be defined as those patients and their family members who meet the following criteria:

  • Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus.
  • Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent.  Ability to give informed consent, if patient is age 18 or older.

BE Tissue Collection

Cell culture from GERD and Barrett's Esophagus

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