Hodgkin lymphoma has four different stages as classified by the Modified Ann Arbor Staging System:
- Stage I. Single lymph node region or organ involved with disease.
- Stage II. Two or more lymph node regions involved on the same side of the diaphragm (the muscle that controls breathing and that separates the chest from the abdomen).
- Stage III. Lymph node regions involved on both sides of the diaphragm.
- Stage IV. Significant involvement of an organ that is not considered part of the lymphatic system (like the lung or liver) or any organ involvement along with lymph node involvement.
- Additional designations:
- "B": Unexplained fevers, chills, drenching night sweats, weight loss or fatigue
- "E": Non-lymph node disease that fits into a single area of radiation therapy
- "X": Bulky (large) mass, frequently in the mediastinum (chest)
Typically, stage I or II Hodgkin lymphoma is considered "early" stage and stage III or IV is considered "advanced" stage.
Within early stage, patients with low-risk features are considered "favorable" and patients not meeting criteria for low-risk disease are considered "unfavorable".