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Diagnosing Chronic Myelomonocytic Leukemia (CMML)

Tests that examine the blood and bone marrow are used to detect (find) and diagnose chronic myelomonocytic leukemia (CMML).

The Penn hematopathology service is a national leader in the diagnosis of neoplastic and reactive hematologic disorders, with broad expertise in myelodysplastic syndromes (MDS).

Working closely with the clinical team, Penn hematopathologists provide integrative, state-of-the art analysis using histology and a wide array of ancillary techniques, including:

  • Flow cytometry
  • Immunohistochemistry
  • Cytogenetics
  • FISH
  • The latest molecular studies (ranging from single gene assays to next generation sequencing) to ensure the most accurate and precise diagnosis for every patient.

Preparing for A Second Opinion

If you were diagnosed at another health care center, and are coming to the Abramson Cancer Center for treatment or a second opinion, repeat diagnostic tests may be necessary.

Other things we may request in advance of your second opinion visit include:

  • Pathology slides
  • Health records
  • A list of dates and facts about your past treatments, personal health history, or any other facts and dates relevant to your current diagnosis.

Perhaps most importantly, however, come to your visit with a list of as many questions as possible. Sometimes, it can be difficult to think of everything or remember everything during a visit. A list of questions prepared in advance will ensure you get the information you are looking for.

If you forget a question, or have more questions after your visit, you can communicate with your treatment team by phone, or by using our secure electronic portal:

Finally, plan to have a friend, family member or support person come with you to your appointment. He or she can help take down information, recall the details of the conversation and be of general support throughout the process.

Diagnostic Tools for CMML

At Penn Medicine, diagnosing chronic myelomonocytic leukemia (CMML) includes comprehensive tests and procedures that result in accurate evaluations.

Staging CMML

Abramson Cancer Center groups chronic myelomonocytic leukemia (CMML) into two stages after diagnostic testing is complete.