Description of Research Expertise

Clinical research in Fibrodysplasia Ossificans Progressiva.
Evaluation of osteoporosis and the effects of treatment/diseases on "bone quality" using high resolution imaging of bone (uMRI).

Selected Publications

Pignolo RJ, Al Mukaddam M, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Le Quan Sang KH, Grogan DR, Marino R, Strahs AR, Kaplan FS.: Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva BMC Med Res Methodol : 2023.

Pignolo RJ, Al Mukaddam M, Baujat G, Brown MA, De Cunto C, Hsiao EC, Keen R, Le Quan Sang KH, Grogan DR, Marino R, Strahs AR, Kaplan FS.: Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva. BMC Med Res Methodol : 2023.

Robert J Pignolo, Mona Al Mukaddam, Geneviève Baujat, Angela M Cheung, Carmen De Cunto, Edward C Hsiao, Richard Keen, Rose Marino, Andrew Strahs, Frederick S Kaplan: Health Assessments of Normotopic Bone in Individuals with Fibrodysplasia Ossificans Progressiva Poster Presentation at the Annual ASBMR meeting : 2023.

Bassam AlHamer, Ajit Singh, Carmen Patrascu, Mona Al Mukaddam: How an underappreciated electrolyte abnormality led to a rare diagnosis Poster Presentation at ACP meeting (awarded second best poster prize) : 2023.

Kathryn M. Dahir, Jennifer McGinniss, Eduardo Forleo-Neto, Scott Mellis, Robert J. Sanchez, Maja Di Rocco, Richard Keen, Philippe Orcel, Christian Roux, Jacek Tabarkiewicz, Javier Bachiller-Corral, Angela M. Cheung, Mona Al Mukaddam, Kusha Mohammadi, Dushyanth Srinivasan, Andrew J. Rankin, Aris N. Economides, Dinko Gonzalez Trotter, Frederick S. Kaplan, E. Marelise W. Eekhoff, Robert J. Pignolo: Flare-Ups in Patients with Fibrodysplasia Ossificans Progressiva Reduced by Garetosmab Treatment: LUMINA-1 Data Poster Presentation at the Annual ASBMR meeting : 2023.

Edward C. Hsiao, Robert J. Pignolo, Mona Al Mukaddam, Geneviève Baujat, , Staffan K. Berglund, Angela M. Cheung, Carmen De Cunto, Patricia Delai, , Peter Kannu, Richard Keen, Edna E. Mancilla, Rose Marino, Andrew Strahs, Frederick S. Kaplan: Long-Term Impact of Palovarotene Treatment on Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva: Data from the Phase III MOVE Trial Poster Presentation at ASBMR annual meeting : 2023.

Richard Keen, Jennifer McGinniss, Eduardo Forleo-Neto, Scott Mellis, Kathryn M. Dahir, Maja Di Rocco, Jacek Tabarkiewicz, Javier Bachiller-Corral, Angela M. Cheung, Mona Al Mukaddam, Jing Gu, Aris N. Economides, Dushyanth Srinivasan, Dinko Gonzalez Trotter, Frederick S. Kaplan, Marelise W. Eekhoff, Robert J. Pignolo: The Relationship of Flare-Ups and Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva: LUMINA-1 Data Plenary Poster Presentation at Annual ASBMR meeting : 2023.

Edward C. Hsiao, Robert J. Pignolo, Mona Al Mukaddam, Geneviève Baujat, , Staffan K. Berglund, Angela M. Cheung, Carmen De Cunto, Patricia Delai, , Peter Kannu, Richard Keen, Edna E. Mancilla, Rose Marino, Andrew Strahs, Frederick S. Kaplan: Efficacy of Palovarotene for the Reduction of New Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva: Sensitivity Analyses from the Phase III MOVE Trial Poster Presentation at Annual ASBMR meeting : 2023.

Di Rocco M, Forleo-Neto E, Pignolo RJ, Keen R, Orcel P, Funck-Brentano T, Roux C, Kolta S, Madeo A, Bubbear JS, Tabarkiewicz J, Szczepanek M, Bachiller-Corral J, Cheung AM, Dahir KM, Botman E, Raijmakers PG, Al Mukaddam M, Tile L, Portal-Celhay C, Sarkar N, Hou P, Musser BJ, Boyapati A, Mohammadi K, Mellis SJ, Rankin AJ, Economides AN, Trotter DG, Herman GA, O'Meara SJ, DelGizzi R, Weinreich DM, Yancopoulos GD, Eekhoff EMW, Kaplan FS.: Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial. Nature Medicine : 2023.

Jones BC, Wehrli FW, Kamona N, Deshpande RS, Vu BD, Song HK, Lee H, Grewal RK, Chan TJ, Witschey WR, MacLean MT, Josselyn NJ, Iyer SK, Al Mukaddam M, Snyder PJ, Rajapakse CS: Automated, calibration-free quantification of cortical bone porosity and geometry in postmenopausal osteoporosis from ultrashort echo time MRI and deep learning Bone : 2023.

Academic Contact Information

3rd floor Penn Medicine University City
3737 Market Street
Philadelphia, PA 19104
Phone: 215-662-9905
Patient appointments: 800-789-7366