Research and Clinical Trials
Research
More people are surviving end-stage organ disease than ever before. Over the last decade, many people with heart, kidney, liver, and lung disease have witnessed the success of research studies that have helped improve and increase treatment options.
As an experienced transplant center in an academic setting, Penn Transplant Institute is committed to finding new and better treatments for transplant patients.
For an overview of current research, click on an organ:
Heart Transplant
Areas of Emphasis: Isolated and combined (with other organ)
transplants in patients with multiple co-morbidities; bridge-to-transplant
and recovery in patients requiring mechanical-assist devices; transplant in
adult congenital heart disease patients.
Principal Research Areas: Testing and evaluation of new anti-rejection
drugs and regimens; early identification and outpatient management of chronic
heart failure patients; use of cell regenerative therapies for recovery; genomic
identification of risk factors for cardiomyopathy; outcomes analysis in
bridge-to-transplant and double organ transplant patients; testing and use of
new mechanical assist devices.
Kidney Transplant
Areas of Emphasis: Increasing long-term graft survival; living donor advocacy,
judicious use of expanded deceased donors, transplant in patients with HIV.
Principal Research Areas: Ongoing trials for
immunosuppression protocols, vascular disease role in graft outcomes, improved protection
from infectious disease in transplant patients.
Liver Transplant
Areas of Emphasis: Treatment of HCV pre- and post-transplant,
transplantation for HCC, adult-to-adult living donor outcomes, expanding the
use of DCD and higher DRI donors, multi-organ transplantation,
immunosuppression minimization, adolescent to adult transitioning,
transplant in patients with HIV.
Principal Research Areas:
Immunosuppression withdrawal, molecular markers of graft tolerance,
liver regeneration, gene expression of injury and inflammation following
liver transplantation, infectious disease in transplant recipients.
Lung Transplant
Areas of Emphasis: Focus on novel therapeutics for advanced
lung disease with programs dedicated to interstitial lung disease,
adult cystic fibrosis,
pulmonary vascular disease and management of COPD; minimally
invasive surgical approach is standard practice in our program.
Principal Research Areas: Risk factors for the natural history of
primary graft dysfunction and novel immunosuppression strategies.
Pancreas Transplant
Areas of Emphasis: Improved graft outcomes in pancreas and SPK.
Principal Research Areas: Islet cell transplant in patients with
type 1 diabetes.
Need an appointment? Request
one online 24 hours/day, 7 days/week or call 800-789-PENN (7366)
to speak to a referral counselor.
Areas of Emphasis: Isolated and combined (with other organ) transplants in patients with multiple co-morbidities; bridge-to-transplant and recovery in patients requiring mechanical-assist devices; transplant in adult congenital heart disease patients.
Principal Research Areas: Testing and evaluation of new anti-rejection drugs and regimens; early identification and outpatient management of chronic heart failure patients; use of cell regenerative therapies for recovery; genomic identification of risk factors for cardiomyopathy; outcomes analysis in bridge-to-transplant and double organ transplant patients; testing and use of new mechanical assist devices.
Areas of Emphasis: Increasing long-term graft survival; living donor advocacy, judicious use of expanded deceased donors, transplant in patients with HIV.
Principal Research Areas: Ongoing trials for immunosuppression protocols, vascular disease role in graft outcomes, improved protection from infectious disease in transplant patients.
Liver Transplant
Areas of Emphasis: Treatment of HCV pre- and post-transplant,
transplantation for HCC, adult-to-adult living donor outcomes, expanding the
use of DCD and higher DRI donors, multi-organ transplantation,
immunosuppression minimization, adolescent to adult transitioning,
transplant in patients with HIV.
Principal Research Areas:
Immunosuppression withdrawal, molecular markers of graft tolerance,
liver regeneration, gene expression of injury and inflammation following
liver transplantation, infectious disease in transplant recipients.
Lung Transplant
Areas of Emphasis: Focus on novel therapeutics for advanced
lung disease with programs dedicated to interstitial lung disease,
adult cystic fibrosis,
pulmonary vascular disease and management of COPD; minimally
invasive surgical approach is standard practice in our program.
Principal Research Areas: Risk factors for the natural history of
primary graft dysfunction and novel immunosuppression strategies.
Pancreas Transplant
Areas of Emphasis: Improved graft outcomes in pancreas and SPK.
Principal Research Areas: Islet cell transplant in patients with
type 1 diabetes.
Need an appointment? Request
one online 24 hours/day, 7 days/week or call 800-789-PENN (7366)
to speak to a referral counselor.
Areas of Emphasis: Treatment of HCV pre- and post-transplant, transplantation for HCC, adult-to-adult living donor outcomes, expanding the use of DCD and higher DRI donors, multi-organ transplantation, immunosuppression minimization, adolescent to adult transitioning, transplant in patients with HIV.
Principal Research Areas: Immunosuppression withdrawal, molecular markers of graft tolerance, liver regeneration, gene expression of injury and inflammation following liver transplantation, infectious disease in transplant recipients.
Areas of Emphasis: Focus on novel therapeutics for advanced lung disease with programs dedicated to interstitial lung disease, adult cystic fibrosis, pulmonary vascular disease and management of COPD; minimally invasive surgical approach is standard practice in our program.
Principal Research Areas: Risk factors for the natural history of primary graft dysfunction and novel immunosuppression strategies.
Pancreas Transplant
Areas of Emphasis: Improved graft outcomes in pancreas and SPK.
Principal Research Areas: Islet cell transplant in patients with
type 1 diabetes.
Need an appointment? Request
one online 24 hours/day, 7 days/week or call 800-789-PENN (7366)
to speak to a referral counselor.
Areas of Emphasis: Improved graft outcomes in pancreas and SPK.
Principal Research Areas: Islet cell transplant in patients with type 1 diabetes.
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Need an appointment? Request one online 24 hours/day, 7 days/week or call 800-789-PENN (7366) to speak to a referral counselor. |
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