Penn Transplant Institute

Clinical Trials

Heart Transplant
Human heart tissue protocol
Clinical Trials in Organ Transplantation (CTOT) Studies
Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan) Therapy in Cardiac Transplantation
  • Investigator: Lee Goldberg, MD
A Prospective, Randomized, Multicenter, Two-Parallel Arm Study Evaluating the Overall Efficacy and Safety of Desensitization Therapy on Selected Patients Awaiting Heart Transplantation
  • Investigator: Lee Goldberg, MD
Kidney Transplant
A Phase 2 Double-Blind, Double-dummy, Multicenter, Prospective, Randomized Study of the Pharmacokinetics of LCP-Tacro Tablets, Once-Daily, Compared to Prograf Capsules, Twice-daily, for the Prevention of Acute Allograft Rejection in De Novo Adult Kidney Transplant Recipients
Clinical trials in organ transplantation (CTOT)
End Stage Disease and Mortality after Kidney Donation: A Determination of Incidence
Determination of Sensitization after Transplant Nephrectomy
The Impact of Donor Hemodynamic Events on Kidney and Liver Allograft Outcomes in Donation after Cardiac Death Donors
Effect of Thymoglobulin versus Basiliximab on Regulatory T Cell Function in Live Donor Kidney Transplant Recipients
Solid Organ Transplant After Hematopoietic Cell Transplantation (HCT)
Liver Transplant
Effects of Rapamycin on Gene Expression and Biomarkers Associated with Aging
Penn Transplant Biobank and Registry (BioTip)
A2ALL-2: Adult-to-Adult Living Donor Liver Transplant Cohort Study
  • Investigator: Kim Olthoff, MD
Clinical, immunologic and pharmacologic consequences of liver transplantation in people with HIV infection
  • Investigator: Kim Olthoff, MD
Safety and efficacy study of N-acetylcysteine in the treatment of acute liver failure not caused by acetaminophen in adult patients
An observational database of patients who receive orthotopic liver transplantation (OLT) for hepatitis B
Comparison of HepeX-BTM, a mixture of two monoclonal antibodies, to hepatitis B immune globulin in patients who have received hepatic allografts for treatment of end-stage liver disease due to hepatitis B virus infection
Intravenous terlipressin in patients with hepatorenal syndrome type I
Predictors of Renal Dysfunction Following Liver Transplantation
Influence of Donor Hepatic Graft Histology on Liver Graft Failure
Donation After Cardiac Death Tissue Plasminogen Activator (TPA) Protocol
The Impact of Donor Hemodynamic Events on Kidney and Liver Allograft Outcomes in Donation after Cardiac Death Donors
Pilot Study: Calcineurin Inhibitor Use on Regulatory T Cells in Adult Liver Transplant Recipients*
Solid Organ Transplant After Hematopoietic Cell Transplantation (HCT)
Genomic Analysis of Liver Cancer Recurrence After Liver Transplantation
Retrospective Analysis (Patients Who Underwent Liver Transplant for Hepatic Cellular Carcinoma at Penn)
Retrospective Analysis of Patients With Simultaneous Thoracic and Abdominal Organ Transplantation
Prognostic Factors for Long Term Graft Survival in Orthotopic Liver Transplant (OLT) Patients Over the Age of 65
Evaluation of Short and Long-Term Results of Redo Liver Transplantation from 1996 to 2011: A Single Center Experience
Long Term Allograft Function and Pattern of Injury Following Discontinuation of Immunosuppression After Orthotopic Liver Transplantation
HCC Metastasis to the Adrenal Glands and Lungs Following Orthotopic Liver Transplant: Prognosis of Surgical Treatment
Graft Outcomes of Pediatric Hepatitis C Liver Transplant Recipients: Analysis of the UNOS Database
Lung Transplant
Clinical Risk Factors of Primary Graft Failure, a Multicenter Study
Genetics of Primary Graft Failure, a Multicenter Study
Clinical Trials in Organ Transplantation
The association of anti-Col (V) antibodies with development of Primary Graft Dysfunction following lung transplantation
Regulatory T Cells and Primary Graft Failure
Innate Immunity and lung transplantation
Prospective Registry of Outcomes in Patients Electing Lung Transplantation (PROPEL): A correlative analysis using gene signature array
NOVEL Lung Trial: Normothermic Ex Vivo Lung Perfusion (EVLP) as an Assessment of Extended/Marginal Donor Lungs
A Multi-center, Multinational, Retrospective Review of Voriconazole Experience for the Prophylaxis against Invasive Aspergillosis in Lung Transplant Recipients

Advanced Lung Disease Research Studies

Bronchiectasis

A Phase 3, Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Evaluating Repeated Courses of Aztreonam for Inhalation Solution in Subjects with non-CF Bronchiectasis and Gram-Negative Endobronchial Infection (AIR-BX1), Gilead
A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions (NON-TREATMENT)
Nontuberculous Mycobacterial Lung Disease (NTM): A randomized, double-blind, placebo-controlled study of Liposomal Amicakcin for inhalation (Arikace) in patients with recalcitrant nontuberculous mycobacterial lung disease
Genomic Research in Alpha 1 Anti-trypsin disease and Sarcoidosis

IPF

A prospective, longitudinal, non-pharmacologic, case-controlled study to evaluate longitudinal disease behavior and biomarker data over a 52 week period in idiopathic pulmonary fibrosis patients
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Efficacy and Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis, InterMune (TREATMENT)

Pulmonary Hypertension

GRIPHON: Prostacyclin (PGI2) Receptor agonist In Pulmonary arterial Hypertension (TREATMENT): A multicenter, double-blind, placebo-controlled Phase 3 study to demonstrate the efficacy and safety of ACT-293987 in patients with pulmonary arterial hypertension
AIPH: Anastrozole in Patients with Pulmonary Arterial Hypertension (TREATMENT)

Cystic Fibrosis

A randomized, multi-center, open-label, cross over, phase IV study in cystic fibrosis (CF) patients to compare the tolerability, safety and efficacy of tobramycin inhalation powder (TIP) with tobramycin nebulizer solution (TOBI) as assessed by the switch-over of treatments
A prospective, 5-year Registry Study to Monitor the Susceptibility to Aztreonam of Pseudomonas aeruginosa (PA) Isolates from Patients with Cystic Fibrosis in the United States
Cystic Fibrosis Foundation Patient Registry
Continuous Alternating Therapy (CAT) Regimen of Inhaled Antibiotics for the Treatment of Chronic Pulmonary Pseudomonas aeruginosa infection
Cell Mediated Immunity Against the Cystic Fibrosis Transmembrane Conductance Regulator Protein in Patients with Cystic Fibrosis (3 blood draws)
Modulation of inflammation and oxidation biomarkers in cystic fibrosis by a botanical phenolic
  • Investigator: Jason Turowski, MD
Improving the Effectiveness of Pulmozyme at sites of infection by Combination with Multivalent Anions and Acting Depolymerizing Factors
  • Investigator: Paul Jamney, PhD
Pancreas Transplant
Islet transplantation in type 1 diabetes using immunosuppression and strategies to improve long term graft survival
Using anti-B lymphocyte agent rituximab (Rituxan) to improve long-term graft survival
Islet transplantation vs. intensive insulin therapy in patients with type 1 diabetes who have already received a kidney transplant