Clinical Trials | Research & Clinical Trials

Heart Transplant

Human heart tissue protocol

Investigator: Kenneth Margulies, MD
Sponsored by: National Institutes of Health (NIH)

Clinical Trials in Organ Transplantation (CTOT) Studies

Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan) Therapy in Cardiac Transplantation

Investigator: Lee Goldberg, MD
Sponsored by: National Institutes of Health (NIH)

A Prospective, Randomized, Multicenter, Two-Parallel Arm Study Evaluating the Overall Efficacy and Safety of Desensitization Therapy on Selected Patients Awaiting Heart Transplantation

Investigator: Lee Goldberg, MD
Sponsored by: National Institutes of Health (NIH)

Kidney Transplant

A Phase 2 Double-Blind, Double-dummy, Multicenter, Prospective, Randomized Study of the Pharmacokinetics of LCP-Tacro Tablets, Once-Daily, Compared to Prograf Capsules, Twice-daily, for the Prevention of Acute Allograft Rejection in De Novo Adult Kidney Transplant Recipients

Investigator: Roy D. Bloom, MD

Clinical trials in organ transplantation (CTOT)

Investigator: Abraham Shaked, MD, PhD
Sponsored by: National Institutes of Health

End Stage Disease and Mortality after Kidney Donation: A Determination of Incidence

Investigator: Peter Abt, MD

Determination of Sensitization after Transplant Nephrectomy

Investigator: Peter Abt, MD

The Impact of Donor Hemodynamic Events on Kidney and Liver Allograft Outcomes in Donation after Cardiac Death Donors

Investigator: Peter Abt, MD

Effect of Thymoglobulin versus Basiliximab on Regulatory T Cell Function in Live Donor Kidney Transplant Recipients

Investigator: Matthew Levine, MD, PhD

Solid Organ Transplant After Hematopoietic Cell Transplantation (HCT)

Investigator: Matthew Levine, MD, PhD

Liver Transplant

Effects of Rapamycin on Gene Expression and Biomarkers Associated with Aging

Investigator: Abraham Shaked, MD, PhD

Penn Transplant Biobank and Registry (BioTip)

Investigator: Kim Olthoff, MD

A2ALL-2: Adult-to-Adult Living Donor Liver Transplant Cohort Study

Investigator: Kim Olthoff, MD
Sponsored by: National Institutes of Health

Clinical, immunologic and pharmacologic consequences of liver transplantation in people with HIV infection

Investigator: Kim Olthoff, MD
Sponsored by: National Institutes of Health

Safety and efficacy study of N-acetylcysteine in the treatment of acute liver failure not caused by acetaminophen in adult patients

Investigator: K. Rajender Reddy, MD
Sponsored by: National Institutes of Health

An observational database of patients who receive orthotopic liver transplantation (OLT) for hepatitis B

Investigator: K. Rajender Reddy, MD

Comparison of HepeX-BTM, a mixture of two monoclonal antibodies, to hepatitis B immune globulin in patients who have received hepatic allografts for treatment of end-stage liver disease due to hepatitis B virus infection

Investigator: K. Rajender Reddy, MD

Intravenous terlipressin in patients with hepatorenal syndrome type I

Investigator: K. Rajender Reddy, MD

Predictors of Renal Dysfunction Following Liver Transplantation

Investigator: Peter Abt, MD

Influence of Donor Hepatic Graft Histology on Liver Graft Failure

Investigator: Peter Abt, MD

Donation After Cardiac Death Tissue Plasminogen Activator (TPA) Protocol

Investigator: Peter Abt, MD

The Impact of Donor Hemodynamic Events on Kidney and Liver Allograft Outcomes in Donation after Cardiac Death Donors

Investigator: Peter Abt, MD

Pilot Study: Calcineurin Inhibitor Use on Regulatory T Cells in Adult Liver Transplant Recipients*

Investigator: Matthew Levine, MD, PhD
*open but not currently enrolling

Solid Organ Transplant After Hematopoietic Cell Transplantation (HCT)

Investigator: Matthew Levine, MD, PhD

Genomic Analysis of Liver Cancer Recurrence After Liver Transplantation

Investigator: Matthew Levine, MD, PhD

Retrospective Analysis (Patients Who Underwent Liver Transplant for Hepatic Cellular Carcinoma at Penn)

Investigator: Matthew Levine, MD, PhD

Retrospective Analysis of Patients With Simultaneous Thoracic and Abdominal Organ Transplantation

Investigator: Kim Olthoff, MD

Prognostic Factors for Long Term Graft Survival in Orthotopic Liver Transplant (OLT) Patients Over the Age of 65

Investigator: Kim Olthoff, MD

Evaluation of Short and Long-Term Results of Redo Liver Transplantation from 1996 to 2011: A Single Center Experience

Investigator: Kim Olthoff, MD

Long Term Allograft Function and Pattern of Injury Following Discontinuation of Immunosuppression After Orthotopic Liver Transplantation

Investigator: Abraham Shaked, MD, PhD

HCC Metastasis to the Adrenal Glands and Lungs Following Orthotopic Liver Transplant: Prognosis of Surgical Treatment

Investigator: Abraham Shaked, MD, PhD

Graft Outcomes of Pediatric Hepatitis C Liver Transplant Recipients: Analysis of the UNOS Database

Investigator: Abraham Shaked, MD, PhD

Lung Transplant

Clinical Risk Factors of Primary Graft Failure, a Multicenter Study

Investigator: Jason D. Christie, MD

Genetics of Primary Graft Failure, a Multicenter Study

Investigator: Jason D. Christie, MD

Clinical Trials in Organ Transplantation

Investigator: Jason D. Christie, MD

The association of anti-Col (V) antibodies with development of Primary Graft Dysfunction following lung transplantation

Investigator: Jason D. Christie, MD

Regulatory T Cells and Primary Graft Failure

Investigator: Jason D. Christie, MD

Innate Immunity and lung transplantation

Investigator: Joshua Diamond, MD

Prospective Registry of Outcomes in Patients Electing Lung Transplantation (PROPEL): A correlative analysis using gene signature array

Investigator: Edward Cantu III, MD

NOVEL Lung Trial: Normothermic Ex Vivo Lung Perfusion (EVLP) as an Assessment of Extended/Marginal Donor Lungs

Investigator: Edward Cantu III, MD

A Multi-center, Multinational, Retrospective Review of Voriconazole Experience for the Prophylaxis against Invasive Aspergillosis in Lung Transplant Recipients

Investigator: Denis Hadjiliadis, MD

Advanced Lung Disease Research Studies

Bronchiectasis

A Phase 3, Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Evaluating Repeated Courses of Aztreonam for Inhalation Solution in Subjects with non-CF Bronchiectasis and Gram-Negative Endobronchial Infection (AIR-BX1), Gilead

Investigator: Gregory Tino, MD

A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions (NON-TREATMENT)

Investigator: Gregory Tino, MD

Nontuberculous Mycobacterial Lung Disease (NTM): A randomized, double-blind, placebo-controlled study of Liposomal Amicakcin for inhalation (Arikace) in patients with recalcitrant nontuberculous mycobacterial lung disease

Investigator: Daniel Dorgan, MD

Genomic Research in Alpha 1 Anti-trypsin disease and Sarcoidosis

Investigator: Milton Rossman, MD & Maryl Kreider, MD, MSCE

LAM

A Trial of Letrozole in Pulmonary Lymphangioleiomyomatosis with or without measurable tumors or lymph nodes

Investigator: Robert Kotloff, MD

IPF

A prospective, longitudinal, non-pharmacologic, case-controlled study to evaluate longitudinal disease behavior and biomarker data over a 52 week period in idiopathic pulmonary fibrosis patients

Investigator: Gregory Tino, MD

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Efficacy and Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis, InterMune (TREATMENT)

Investigator: Gregory Tino, MD

Pulmonary Hypertension

GRIPHON: Prostacyclin (PGI2) Receptor agonist In Pulmonary arterial Hypertension (TREATMENT): A multicenter, double-blind, placebo-controlled Phase 3 study to demonstrate the efficacy and safety of ACT-293987 in patients with pulmonary arterial hypertension

Investigator: Jason Fritz, MD

AIPH: Anastrozole in Patients with Pulmonary Arterial Hypertension (TREATMENT)

Investigator: Steven Kawut, MD

Cystic Fibrosis

A randomized, multi-center, open-label, cross over, phase IV study in cystic fibrosis (CF) patients to compare the tolerability, safety and efficacy of tobramycin inhalation powder (TIP) with tobramycin nebulizer solution (TOBI) as assessed by the switch-over of treatments

Investigator: Denis Hadjiliadis, MD

A prospective, 5-year Registry Study to Monitor the Susceptibility to Aztreonam of Pseudomonas aeruginosa (PA) Isolates from Patients with Cystic Fibrosis in the United States

Investigator: Denis Hadjiliadis, MD

Cystic Fibrosis Foundation Patient Registry

Investigator: Denis Hadjiliadis, MD

Continuous Alternating Therapy (CAT) Regimen of Inhaled Antibiotics for the Treatment of Chronic Pulmonary Pseudomonas aeruginosa infection

Investigator: Denis Hadjiliadis, MD

Cell Mediated Immunity Against the Cystic Fibrosis Transmembrane Conductance Regulator Protein in Patients with Cystic Fibrosis (3 blood draws)

Investigator: Denis Hadjiliadis, MD

Modulation of inflammation and oxidation biomarkers in cystic fibrosis by a botanical phenolic

Investigator: Jason Turowski, MD

Improving the Effectiveness of Pulmozyme at sites of infection by Combination with Multivalent Anions and Acting Depolymerizing Factors

Investigator: Paul Jamney, PhD

Pancreas Transplant

Islet transplantation in type 1 diabetes using immunosuppression and strategies to improve long term graft survival

Investigator: Ali Naji, MD, PhD
Sponsored by: National Institutes of Health

Using anti-B lymphocyte agent rituximab (Rituxan) to improve long-term graft survival

Investigator: Ali Naji, MD, PhD
Sponsored by: National Institutes of Health

Islet transplantation vs. intensive insulin therapy in patients with type 1 diabetes who have already received a kidney transplant

Investigator: Ali Naji, MD, PhD
Sponsored by: National Institutes of Health