Diagnostic Criteria for Sjogren’s Syndrome
Physicians use the European-American Diagnostic
Criteria for Sjogren’s Syndrome*, recently
adopted by the Sjogren’s Syndrome Foundation,
when diagnosing patients with Sjogren’s.
Diagnosis of primary Sjogren’s (1°)
requires four of the six criteria for diagnosis
(including number five or six).
For diagnosis of secondary Sjogren’s (2°),
the patient must have an already established
connective tissue disease, plus criteria number
one or two, and two of the remaining criteria.
- Oral Symptoms (any one of three)
- Dry mouth for more than three months
- Salivary gland swelling
- Need for liquids to swallow food
- Ocular Symptoms (any one of three)
- Dry eyes for more than three months
- Foreign body sensation in eyes
- Use of artificial tears more than three
times per day
- Oral Signs of Sjogren’s (at least
one)
- Abnormal salivary scintigraphy
- Abnormal parotid scalography
- Whole mouth unstimulated flow rate – less
than or equal to 0.1 cc per minute (15-minute
collection)
- Ocular Signs of Sjogren’s (at least
one)
- Positive vital dye staining
- Unanesthetized Schimer’s test – less
than or equal to five millimeters per
five minutes
- Salivary Gland Biopsy
- Positive lip biopsy showing focal lymphocytic
sialadenitis with a focus score of less
than or equal to one per four millimeters
squared
- Autoantibodies
- Positive Anti SSA and/or Anti SSB
*Source: Vitali, C. et al. Annals of Rheumatic
Diseases, 2002.
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