Platelets, Platelet Factor 4, Atherosclerosis, Protein interactions, Murine models, Transcriptional regulation.
Key words: Platelets, Platelet Factor 4, Atherosclerosis, Protein interactions, Murine models, Tanscriptional regulation.
Description of Research
My laboratory is primarily interested in the biology and structure of platelet factor 4 (PF4). PF4 is a cationic protein found in the alpha-granules of platelets and is released upon platelet activation. It binds avidly to glycosaminoglycans on the surface of endothelial cells and is known to inhibit anti-thrombin III, resulting in increased clotting.