The research in our laboratory is focused on elucidating molecular mechanisms of cardiac arrhythmias and conduction disease. We are using genetically engineered mouse models of human arrhythmogenic disorders to investigate the mechanisms underlying these disorderss at the level of the whole heart, the cardiomyocyte and molecule. This integrative approach is accomplished by using the murine in vivo electrophysiology technique in combination with the whole-cell patch clamp technique and employing standard molecular and biochemical approaches. Specifically, our lab has several areas of interest with active research projects investigating
1) The role and contribution to atrial arrhythmogenesis of a newly identified melanocyte-like cell population in the mouse and human pulmonary veins.
2) The transcriptional regulation of cardiac conduction system development and function in mouse models engineered with conduction system deletion of T-box and GATA transcription factors using inducible Mink-Cre and Hcn4-Cre transgenic mice.