Description of Research Expertise
Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI)
Key words: Cancers: esophageal, pancreatic, colon Oncogenes: EGFR, cyclin D1, Ki-Ras Organotypic culture
Description of Research
Our laboratory has had long-standing thematic interests in the cell-type and tissue-type specific actions of certain oncogenes (cyclin D1, Ki-Ras, EGFR) and tumor suppressor genes (p53, p16INK4a) in modulating the initiation, progression and invasion of gastrointestinal cancers, especially upper GI, pancreatic and colon. To that end, we employ novel three-dimensional cell culture systems (mouse and human origins) and geneticaly-engineered mouse models to investigate molecular mechanisms. These projects are translated into the objectives of improving molecular diagnostics and experimental therapeutics in patients.
Our research is funded through an NCI program project entitled "Mechanisms of Esophageal Carcinogenesis", NIH R01 grant on pancreatic cancer, and NIH R01 grant on colon cancer. Students and postdoctoral fellows are supported in didactic venues and conferences, present at national meetings, and have obtained national grant fellowships when applicable.
Rotation Projects for 2015-2016
1. To understand the role of oncogenes (EGFR, cyclin D1, Ras) and tumor suppressor genes (p53, p120catenin) in the tumor microenvironment as they relate to tumor cell migration and invasion in GI cancers, using organotypic culture and mouse models.
2. To define mechanisms underlying cell lineage fate decisions during pancreatic development and cancer
3. To functionally characterize oncogenes in colon cancers.
4. To functionally characterize stem cells in the upper GI tract.
5. Mechanisms underlying tumor metastasis.
Sarah Andres, PhD, Postdoctoral Fellow (NIH F32 Fellowship)
Basil Bakir, MD PhD student, CAMB (thesis project)
Priya Chatterji, PhD Student
Meredith Collins, PhD, Postdoctoral Researcher
Koushik Das, MD, Gastroenterology fellow
Veronique Giroux, PhD, Postdoctoral Researcher (Canadian fellowship)
Kathryn Hamilton, PhD, Research Associate(NIH K01 and CCFA grants)
Arjun Jeganathan, MD, Gastroenterology Surgery Resident
Tatiana Karakasheva, PhD student, CAMB (thesis project)
Apple Long, MD PhD student, CAMB (PhD thesis project)
Benoit Marchand, PhD, Postdoctoral Fellow
Mizuno Rei, MD, Postdoctoral Fellow
Ben Rhoades, M.B., Research specialist and lab manager
Recently in Lab:
Daniel Abravanel, University of Pennsylvania, Rotating MD, PhD Student Claudia Andl, PhD, Research Associate (recipient of NIH K01 grant and AGA Research Scholar Award). Now faculty at Vanderbilt University.
Amy Demicco,University of Pennsylvania, Rotating PhD Student
Brent Fargnoli, University of Pennsylvania undergraduate student (University and Ben Franklin Scholar). Now medical student at University of Pennsylvania.
Christie Gutierrez, University of Pennsylvania, Undergraduate student (AGA student fellowship)
Katharine D. Grugan, PhD,Postdoctoral fellow (recipient of NIH F32 fellowship). Currently, at Centocor.
Christopher Hahn, BA, Research Specialist
Steffen Heeg, MD, Postdoctoral Researcher (German Cancer Society fellowship)
Cameron Johnstone, PhD, Research Investigator (recipient of American Association for Cancer Research fellowship and Department of Defense grant). Now at Peter McCallum Cancer Institute, Melbourne, Australia.
Elizabeth Kennedy, University of Pennsylvania, Rotating PhD student Catrina King, PhD Received her PhD in Dec 2010; graduate of VMD program. Now a resident at Columbia University Medical Center
Emma Lundsmith, medical student (HHMI fellowship)
Blair Madison, PhD, Research Associate (NIH K01 grant), now Assistant Professor of Medicine at Washington University
Carmen Z. Michaylira, PhD, Postdoctoral fellow (recipient of NIH F32 fellowship)
Charles Miller, University of Pennsylvania, Undergraduate student
Perry Mongroo, PhD, Postdoctoral fellow
Keeley Mui, University of Pennsylvania, Rotating PhD Student
Max Reichert, MD, Postdoctoral Researcher (National Pancreas Foundation fellowship)
Anna-Sophie Rich, University of Pennsylvania, Medical Student (recipient of NIH/NIDDK fellowship)
Doug Stairs, PhD, Now Assistant Professor of Pathology, Hershey Medical Center (Recipient of NIH F32 fellowship and NIH K99-R00 grant in lab)
Shigetsugu Takano, MD, Visiting Assistant Professor
Jonathan Toung, University of Pennsylvania, Undergraduate Student (Vagelos Scholar)
Maria Vega, PhD student, CAMB (thesis project; NIH T32 training grant)
Johannes von Burstin, MD, Postdoctoral fellow (recipient of DFG fellowship). At Technical University, Munich, Germany.
Todd Waldron, PhD, Postdoctoral fellow (NIH F32 fellowship)
Melanie P. Wescott, PhD, Postdoctoral fellow (recipient of National Pancreas Foundation fellowship)
Louise Wang, University of Pennsylvania, undergraduate student (NIH fellowship). Now medical student at Stanford University
Rafi Winograd, University of Pennsylvania Rotating MD PhD student
Gabrielle Wong, PhD student, CAMB (thesis project; NIH T32 training grant)
Bihui(Claudia) Xu, University of Pennsylvania Rotating PhD student
Yao Yao, University of Pennsylvania, Rotating DVM PhD Student