Our laboratory broadly focuses on DNA modifying enzymes and pathways, particularly those that contribute to genomic plasticity. We utilize a broad array of approaches, including biochemical characterization of enzyme mechanisms, chemical synthesis of enzyme probes, and biological assays spanning immunology and virology to study the fundamental question of how a genomic diversity arises in nature.
Mutation and modification of the genome play an important role in several physiologically relevant areas and our areas of interest include
1. Decipher the molecular basis for deamination by AID/APOBEC enzymes and perturb deaminase immunological functions