Description of Research Expertise
Dr. Dember conducts patient-oriented research including mechanistic studies and clinical trials in chronic kidney disease and end-stage renal disease (ESRD). She has particular interests in hemodialysis vascular access and interventions to improve clinical outcomes in end-stage renal disease. Her research is funded by the National Institutes of Health. Dr. Dember is Principal Investigator for the Data Coordinating Center of the NIDDK Hemodialysis Novel Therapies Consortium which is conducting early phase clinical trials targeting ESRD-associated inflammation, and she is the Principal Investigator for the "TiME Trial", a large, pragmatic cluster-randomized clinical trial being conducted through the NIH Health Care Systems Research Collaboratory, The TiME Trial will enroll 6400 participants at 400 dialysis units throughout the United States using a highly centralized and efficient implementation approach leveraging the infrastructure of dialysis provider organizations. Dr. Dember is also a principal investigator for the NIDDK Hemodialysis Fistula Maturation Study -- an observational cohort study designed to elucidate predictors and mechanisms of arteriovenous fistula maturation.