Hippocampus; culture; epilepsy; GABA; glutamate; synapse; plasticity; deep brain stimulation.
Epilepsy; epileptogenesis; cortical physiology; regulation of synaptic function; pharmacology of inhibitory and excitatory amino acid receptors
CNS tissue culture; intracellular recording; voltage clamping; patch clamping; immunohistochemistry; chronic eeg monitoring in small animals; brain stimulation
Research focuses on basic mechanisms of epilepsy, the physiology and pharmacology of synaptic transmission between hippocampal neurons, the developmental cell biology of cortical and hippocampal neurons maintained in cell culture, and characteristics of pleuripotent neural progenitor cells. Ongoing projects include methods for brain stimulation to prevent epileptic seizures, mechanisms of epileptogenesis, preventing epilepsy after traumatic brain injury or status epilepticus, mechanisms of progenitor cell differentiation into neurons.