Regulation of T cell responses; regulatory T cell expansion and homeostasis; Natural killer (NK) cell education and signaling
CD8+ T cells, CD4+ T cells, Regulatory T cells, NK cells, Signal Transduction, Cellular Immunology, Antigen Presentation
1) Regulation of T cell responses
T cells are pivotal players in the immune response. They are beneficial in combating infections and cancer but can also be harmful in autoimmunity and immunopathologic states. T cell activation is primarily initiated by intracellular signals emanating through their T cell receptor. These signals can be further modified by engagement of other cell surface receptors and by negative regulators of signaling. Currently, we study the role of the NK cell receptor NKG2D in controlling T cell activation. In addition, we are investigating the roles of negative regulators of calcium and daicylglycerol signaling in T cell activation and differentiation.