Description of Research Expertise

My research is focused on translational studies of clinical and genetic risk factors for Primary Graft Dysfunction (PGD) and chronic rejection after lung transplantation. In addition to increased perioperative mortality, patients recovering from severe PGD have decreased quality of life and an increase risk of chronic rejection, the leading obstacle to long term survival after lung transplantation. Therefore, studies of the mechanisms of PGD and BOS will have a significant impact on the field of lung transplantation and may lead to therapies that improve the overall survival of lung transplant recipients. My current primary research interest is evaluating the role of innate immune activation in the development of post-lung transplant PGD and chronic rejection. I am also actively involved in integrating data on differential innate immune activation with the expanding body of knowledge on microbial colonization and infection of the lower respiratory tract as part of our evaluation of the microbiome of lung transplant recipients

Selected Publications

Diamond Joshua M, Arcasoy Selim, Kennedy Cassie C, Eberlein Michael, Singer Jonathan P, Patterson Glenda M, Edelman Jeffrey D, Dhillon Gundeep, Pena Tahuanty, Kawut Steven M, Lee James C, Girgis Reda, Dark John, Thabut Gabriel: Report of the International Society for Heart and Lung Transplantation Working Group on Primary Lung Graft Dysfunction, part II: Epidemiology, risk factors, and outcomes-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 36 (10): 1104-1113,2017.

Courtwright Andrew M, Zaleski Derek, Gardo Lisa, Ahya Vivek N, Christie Jason D, Crespo Maria, Hadjiliadis Denis, Lee James, Molina Maria, Patel Namrata, Porteous Mary, Cantu Edward E, Bermudez Christian, Diamond Joshua M: Causes, Preventability, and Cost of Unplanned Rehospitalizations Within 30 Days of Discharge Following Lung Transplantation. Transplantation 102 (5): 838-844,2018.

Singer Jonathan P, Diamond Joshua M, Anderson Michaela R, Katz Patricia P, Covinsky Ken, Oyster Michelle, Blue Tatiana, Soong Allison, Kalman Laurel, Shrestha Pavan, Arcasoy Selim M, Greenland John R, Shah Lori, Kukreja Jasleen, Blumenthal Nancy P, Easthausen Imaani, Golden Jeffrey A, McBurnie Amika, Cantu Ed, Sonett Joshua, Hays Steven, Robbins Hilary, Raza Kashif, Bacchetta Matthew, Shah Rupal J, D'Ovidio Frank, Venado Aida, Christie Jason D, Lederer David J: Frailty phenotypes and mortality after lung transplantation: a prospective cohort study. American journal of transplantation 18 (8): 1995-2004,2018.

Tambur Anat R, Campbell Patricia, Claas Frans H, Feng Sandy, Gebel Howard M, Jackson Annette M, Mannon Roslyn B, Reed Elaine F, Tinckam Kathryn, Askar Medhat, Chandraker Anil, Chang Patricia P, Colvin Monica, Demetris Anthony-Jake, Diamond Joshua M, Dipchand Anne I, Fairchild Robert L, Ford Mandy L, Friedewald John, Gill Ronald G, Glotz Denis, Goldberg Hilary, Hachem Ramsey, Knechtle Stuart, Kobashigawa Jon, Levine Deborah J, Levitsky Joshua, Mengel Michael, Milford Edgar, Newell Kenneth A, O'Leary Jacqueline G, Palmer Scott, Randhawa Parmjeet, Smith John, Snyder Laurie, Starling Randall C, Sweet Stuart, Taner Timucin, Taylor Craig J, Woodle Steve, Zeevi Adriana, Nickerson Peter: Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report. American journal of transplantation 18 (7): 1604-1611,2018.

A. Courtwright, M. Molina, L. Gardo, V.N. Ahya, J.D. Christie, J.M. Diamond, D. Hadjiliadis, J. Lee, N. Patel, M. Porteous, E. Cantu, M. Crespo, C. Bermudez: Human Leukocyte Antigen Allosensitization in Patients Bridged to Lung Transplantation with Extracorporeal Membrane Oxygenation The Journal of Heart and Lung Transplantation 37 (4): S89,2018.

Shah Rupal J, Diamond Joshua M: Primary Graft Dysfunction (PGD) Following Lung Transplantation. Seminars in respiratory and critical care medicine 39 (2): 148-154,2018.

Siddiqui Faisal M, Diamond Joshua M: Lung transplantation for chronic obstructive pulmonary disease: past, present, and future directions. Current opinion in pulmonary medicine 24 (2): 199-204,2018.

Negorev Dmitri, Beier Ulf H, Zhang Tianyi, Quatromoni Jon G, Bhojnagarwala Pratik, Albelda Steven M, Singhal Sunil, Eruslanov Evgeniy, Lohoff Falk W, Levine Matthew H, Diamond Joshua M, Christie Jason D, Hancock Wayne W, Akimova Tatiana: Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms. Scientific reports 8 (1): 3135,2018.

Diamond Joshua M, Cantu Edward, Porteous Mary, Suzuki Yoshikazu, Meyer Keith C, Lederer David, Milewski Rita K, Arcasoy Selim, D'Ovidio Frank, Bacchetta Matthew, Sonett Joshua R, Singh Gopal, Costa Joseph, Tobias John W, Rodriguez Hetty, Van Deerlin Vivianna M, Olthoff Kim M, Shaked Abraham, Chang Bao-Li, Christie Jason D: Peripheral Blood Gene Expression Changes Associated with Primary Graft Dysfunction after Lung Transplantation. American Journal of Transplantation 17 (7): 1770-1777,2017.

Crespo Maria M, McCarthy Daniel P, Hopkins Peter M, Clark Stephen C, Budev Marie, Bermudez Christian A, Benden Christian, Eghtesady Pirooz, Lease Erika D, Leard Lorriana, D'Cunha Jonathan, Wigfield Christopher H, Cypel Marcelo, Diamond Joshua M, Yun James J, Yarmus Lonny, Machuzak Michael, Klepetko Walter, Verleden Geert, Hoetzenecker Konrad, Dellgren Göran, Mulligan Michael: ISHLT Consensus Statement on adult and pediatric airway complications after lung transplantation: Definitions, grading system, and therapeutics. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 37 (5): 548-563,2018.

Anderson Brian J, Chesley Christopher F, Theodore Miranda, Christie Colin, Tino Ryan, Wysoczanski Alex, Ramphal Kristy, Oyster Michelle, Kalman Laurel, Porteous Mary K, Bermudez Christian A, Cantu Edward, Kolson Dennis L, Christie Jason D, Diamond Joshua M: Incidence, risk factors, and clinical implications of post-operative delirium in lung transplant recipients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 37 (6): 755-762,2018.

Shaver Ciara M, Wickersham Nancy, McNeil J Brennan, Nagata Hiromasa, Miller Adam, Landstreet Stuart R, Kuck Jamie L, Diamond Joshua M, Lederer David J, Kawut Steven M, Palmer Scott M, Wille Keith M, Weinacker Ann, Lama Vibha N, Crespo Maria M, Orens Jonathan B, Shah Pali D, Hage Chadi A, Cantu Edward, Porteous Mary K, Dhillon Gundeep, McDyer John, Bastarache Julie A, Christie Jason D, Ware Lorraine B: Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury. JCI insight 3 (2): 2018.

Courtwright A, Diamond J M, Wood I, Guleria I, Milford E, El-Chemaly S, Goldberg H J: Detection and clinical impact of human leukocyte antigen antibodies in lung transplantation: A systematic review and meta-analysis. HLA 91 (2): 102-111,2018.

Porteous Mary K, Lee James C, Lederer David J, Palmer Scott M, Cantu Edward, Shah Rupal J, Bellamy Scarlett L, Lama Vibha N, Bhorade Sangeeta M, Crespo Maria M, McDyer John F, Wille Keith M, Localio A Russell, Orens Jonathan B, Shah Pali D, Weinacker Ann B, Arcasoy Selim, Wilkes David S, Ware Lorraine B, Christie Jason D, Kawut Steven M, Diamond Joshua M: Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension. Annals of the American Thoracic Society 14 (10): 1514-1522,2017.

Baldwin Matthew R, Singer Jonathan P, Huang Debbie, Sell Jessica, Gonzalez Wendy C, Pollack Lauren, Maurer Mathew S, D'Ovidio Frank F, Bacchetta Matthew, Sonett Joshua R, Arcasoy Selim M, Shah Lori, Robbins Hilary, Hays Steven R, Kukreja Jasleen, Greenland John R, Shah Rupal J, Leard Lorriana, Morrell Matthew, Gries Cynthia, Katz Patricia P, Christie Jason D, Diamond Joshua M, Lederer David J: Refining Low Physical Activity Measurement Improves Frailty Assessment in Advanced Lung Disease and Survivors of Critical Illness. Annals of the American Thoracic Society 14 (8): 1270-1279,2017.

Diamond Joshua M, Arcasoy Selim, McDonnough Jamiela A, Sonett Joshua R, Bacchetta Matthew, D'Ovidio Frank, Cantu Edward, Bermudez Christian A, McBurnie Amika, Rushefski Melanie, Kalman Laurel H, Oyster Michelle, D'Errico Carly, Suzuki Yoshikazu, Giles Jon T, Ferrante Anthony, Lippel Matthew, Singh Gopal, Lederer David J, Christie Jason D: Adipose Gene Expression Profile Changes with Lung Allograft Reperfusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17 (1): 239-245,2017.

Academic Contact Information

Hospital of the University of Pennsylvania
3400 Spruce St.
9039 West Gates
Philadelphia, PA 19104
Phone: 215-615-5030
Patient appointments: 800-789-7366