1. Mechanisms of intestinal metaplasia of the esophagus (Barrett’s esophagus) and stomach, with a focus on developing novel cell culture and animal models for this disorder.
2. Role of autophagy in the pathogenesis of Barrett’s esophagus, progression to neoplasia, and resistance to therapies.
3. Modeling the effects of Cox-2 activity on oxidative stress and DNA damage in the esophagus.
4. Identification of cells and factors contributing to the intestinal stem cell niche, and their response to injury and disease conditions.
5. Live-cell imaging studies of intestinal stem cell and crypt niche cell interactions, crypt fissioning, mitosis, and early events in neoplastic transformation by confocal microscopy.
6. Role of the intestine-specific transcription factor Cdx2 in promoting intestinal stem cell identity
Description of Research
Barrett’s Esophagus Focus