Genetic and functional characterization of human autoantibody repertoires
Targeted therapy for pemphigus
Regulation of desmosome assembly and disassembly
Key words: autoimmunity, human immunology, cell adhesion, dermatology, skin, cadherin, p38 MAPK
Description of Research
Pemphigus vulgaris (PV) is a potentially fatal disorder in which autoantibodies against desmosomal cell adhesion molecules known as desmogleins cause blistering of the skin and mucous membranes. Our laboratory is interested in better understanding pathogenic mechanisms in this model organ-specific autoimmune disease, from both the immunologic and cell biologic perspectives.