I am a physician scientist with a translational research focus in immunotherapy and cellular therapy. My research goals are to advance the understanding of immune responses mediated by cellular therapies, and to develop approaches that improve their efficacy and/or mitigate their toxicity. In particular, I am interested in how genetic variability affects immune responses and explains the heterogeneity in outcomes of cellular therapies and other immunotherapies. My chief hypothesis is that cellular therapies can be optimized by using personalized approaches that are based on understanding of the genetic heterogeneity of tumors, hosts and donors. In this context, my lab studies the role of lymphocyte trafficking receptors in anti-host and anti-tumor responses, which we have translated into a therapeutic intervention in humans using the CCR5 antagonist maraviroc.