Penn Ob/Gyn Care

Multiple Marker Screening Test (MMS)

The Multiple Marker Screening Test (MMS) is a blood test performed between 15 and 19 weeks of pregnancy to screen for Down syndrome and a birth defect known as spina bifida. The MMS test is commonly referred to as the quad screen test because four substances are measured in the mother's blood.

One tube of blood is required for the quad screen test and no special preparation is needed. For example, you may eat prior to having your blood sample drawn.

The four specific substances measured in the mother's blood originate from the fetus, the placental tissue, or a combination of both. These substances are called alpha feto-protein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol (uE3), and inhibin A.

If you think that you may have a special risk for having a child with birth defects, tell your doctor or call one of our genetic counselors for more information before you have the test.

Penn Ob/Gyn Care physicians and counselors provide prenatal diagnosis, consultation and care at various locations throughout the Philadelphia region. Please call 800-789-PENN (7366) for more information.