Neurosurgery

Laboratories

Complete Publications List

2010

  • Johnson VE, Stewart W, Smith DH. Traumatic brain injury and amyloid-beta pathology: a link to Alzheimer's disease? Nat Rev Neurosci. 2010 [e-pub ahead of print). PMID: 20216546.
  • Haacke EM, Duhaime AC, Gean AD, Riedy G, Wintermark M, Mukherjee P, Brody DL, DeGraba T, Duncan TD, Elovic E, Hurley R, Latour L, Smirniotopoulos JG, Smith DH. Common data elements in radiologic imaging of traumatic brain injury. J Magn Reson Imaging. 32(3): 516-543, Sep 2010. PMID: 20815050.
  • Monnerie H, Tang-Schomer MD, Iwata A, Smith DH, Kim HA, LeRoux PD. Dendritic alterations after dynamic axonal stretch injury in vitro. Exp Neurol. 224(2):415-423, Aug 2010. PMID: 20478308.
  • Smith DH. Can an old head injury suddenly cause detrimental effects much later in life? Scientific American, May 2010.
  • Tang-Schomer MD, Patel AR, Baas PW, Smith DH. Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly and axon degeneration. FASEB. 24(5): 1401-1410, May 2010. PMID: 20019243. PMCID: PMC2879950.
  • Armstead WM, Ganguly K, Kiessling JW, Riley J, Chen XH, Smith DH, Stein SC, Higazi AAR, Cines DB, Bdeir K, Zaitsev S, Muzykantov VR. Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA for treatment of CNS ischemic disorders. J Neurochem. 113(2): 303-312, Apr 2010. PMID: 20405577.

2009

  • Wrathall JR, Benzinger T, Brody DL, Cardin S, Curley K, Mintun M, Mun SK, Wong K, et al. Blast-related brain injury: Imaging for clinical and research applications, Report of the 2008 St. Louis Workshop. J Neurotrauma. 26(12): 2127-2144, Dec 2009. PMID: 19508154. PMCID: PMC2824226.
  • Smith DH. Stretch growth of integrated axon tracts: Extremes and exploitations. Prog Neurobiol. 89(3): 231-239, 2009. PMID: 19664679.
  • Yuen TJ, Browne KB, Iwata A, Smith DH. Sodium channelopathy induced by mild axonal trauma worsens outcome after a repeat injury. J Neurosci Res. 87(16): 3620-5, 2009. PMID: 19565655.
  • Pfister BJ, Chickola L, Smith DH. Head motions while riding roller coasters: Implications for brain injury. Am J Foren Med Pathol. 30(4): 339-45, 2009. PMID: 19901817. PMCID: PMC2796436.
  • Stein SC, Ganguly K, Belfield CM, Xu X, Swanson EW, Chen XH, Browne KD, Johnson VE, Smith DH, Lebold DG, Cines DB, Muzykhantov VR. Erythrocyte-bound tissue plasminogen activator (tPA) is neuroprotective in experimental traumatic brain injury. J Neurotrauma. 26(9): 1585-92, 2009. PMID: 19331516. PMCID: PMC2766435.
  • Huang JH, Cullen DK, Browne KD, Groff R, Zhang J, Pfister BJ, Zager EL, Smith DH. Long-Term Survival and Integration of Transplanted Engineered Nervous Tissue Constructs Promotes Peripheral Nerve Regeneration. Tissue Eng Part A 15(7): 1677-1685, 2009. PMID: 19231968. PMCID: PMC2792099.
  • Armstead WM, Ganguly K, Kiessling JW, Chen XH, Smith DH, Higazi AR, Cines DB, Bdeir K, Zaitsey S, Muzykantoy VR. RBC-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation. J Cereb Blood Flow Metab. 29(8): 1463-1474, 2009. PMID: 19436314. PMCID: PMC2719676.
  • Johnson VE, Stewart W, Stewart JE, Graham DI, Praestgaard AH, Smith DH. A neprilysin polymorphism and amyloid-beta plaques after traumatic brain injury. J Neurotrauma. 26(8): 1197-1202, Aug 2009. PMID: 19326964. PMCID: PMC2850253.
  • Chen YC, Smith DH, Meaney DF. In vitro approaches for studying blast induced traumatic brain injury. J Neurotrauma. 26(6): 861-876, Jun 2009. PMID: 19397424. PMCID: PMC2803321.
  • vonReyn CR, Spaethling JM, Mesfin MN, Ma M, Neumar RW, Smith DH, Siman R, Meaney DF. Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit. J Neurosci. 29(33): 10350-10356, 2009. PMID: 19692609. PMCID: PMC2799681.
  • Chen X-H, Johnson VE, Uryu K, Trojanowski JQ, Smith DH. A lack of amyloid β plaques despite persistent accumulation of amyloid β in axons of long-term survivors of traumatic brain injury. Brain Pathol. 19(2): 2214-23, Apr 2009. PMID: 18492093.

2008

  • Cullen DK, Patel A, Doorish JF, Smith DH, Pfister BJ. Developing a tissue engineered neural-electrical relay using encapsulated neuronal constructs on conducting polymer fibers. J Neural Eng. 5(4): 374-84, Dec 2008. PMID: 18827311.
  • Kameswaran N, Cullen DK, Pfister BJ, Ranalli NJ, Huang JH, Zager EL, Smith DH. A novel neuroprosthetic interface with the peripheral nervous system using artificially engineered axon tracts. Neurol Res. 30(10): 1063-7, Dec 2008. PMID: 19079981.
  • Zhang J, Groff R, Chen X-H, Browne KD, Huang J, Schwartz ED, Meaney DF, Johnson VE, Stein SC, Rojkjaer R, Smith DH. Hemostatic and neuroprotective effects of human recombinant activated factor VII therapy after traumatic brain injury in pigs. Exp Neurol. 210(2): 645-55, Apr 2008. PMID: 18291370.
  • Huang JH, Zager EL, Zhang J, Groff IV RG, Pfister BJ, Cohen AS, Grady MS, Maloney-Wilensky E, Smith DH. Harvested human neurons engineered as live nervous tissue constructs: Implications for transplantation. J Neurosurg. 108(2): 343-7, Feb 2008. PMID: 18240932.

2007

  • Uryu K, Chen X-H, Martinez D, Browne KD, Johnson VE, Graham DI, Lee VM-Y, Trojanowski JQ, Smith DH. Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans. Exp Neurol. 208(2): 185-92, Dec 2007. PMID: 17826768.
  • Pfister BJ, Huang JH, Kameswaran N, Smith DH. Neural engineering to produce in vitro nerve constructs and neural interface. Neurosurgery. 60(1): 137-41, Jan 2007. PMID: 17228262.

2006

  • Armstead WM, Nassar T, Akkawi S, Smith DH, Chen X-H, Cines DB, Higazi AA. Neutralizing the neurotoxic effects of exogenous and endogenous tPA. Nat Neurosci. 9(9): 1150-1155, Sep 2006. PMID: 16936723.
  • Stein SC, Graham DI, Chen X-H, Browne KB, Smith DH. Thromboembolism and delayed cerebral ischemia following subarachnoid hemorrhage: An autopsy study. Neurosurgery. 59(4): 781-7, 2006. PMID: 16915120.
  • Browne KD, Iwata A, Putt MD, Smith DH. Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats. Exp Neurol. 201(2): 301-7, 2006. PMID: 16764859.
  • Iwata A, Browne KD, Pfister BJ, Gruner JA, Smith DH. Long-term survival and outgrowth of mechanically engineered nerve constructs implanted into spinal cord lesions. Tissue Eng. 12(1): 101-110, 2006. PMID: 16499447.
  • Jette N, Coderre E, Nikolaeva MA, Enright PD, Iwata A, Smith DH, Jiang Q, Stys PK. Spatiotemporal distribution of spectrin breakdown products by anoxia in adult optic nerve in vitro. J Cereb Blood Flow Metab. 26(6): 777-86, 2006. PMID: 16163297.
  • Pfister BJ, Iwata A, Taylor AG, Wolf JA, Meaney DF, Smith DH. Development of transplantable nervous tissue constructs comprised of stretch-grown axons. J Neurosci Methods. 153(1): 95-103, May 2006. PMID: 16337007.
  • Pfister BJ, Bonislawski DP, Smith DH, Cohen AS. Stretch-grown axons retain the ability to transmit active electrical signals. FEBS Lett. 580(14): 3525-31, May 2006. PMID: 16730003.
  • Maxwell WL, MacKinnon MA, Smith DH, McIntosh TK, Graham DI. Thalamic nuclei after human blunt head injury. J Neuropathol Exp Neurol. 65(5):478-88, 2006. PMID: 16772871.
  • Iwata A, Browne KD, Pfister BJ, Gruner JA, Smith DH. Long-term survival and outgrowth of mechanically engineered nervous tissue constructs implanted into spinal cord lesions. Tissue Eng. 12(1): 101-110, Jan 2006. PMID: 16499447.

2005

  • Stein SC, Graham DI, Chen X-H, Dunn L, Smith DH. Apo E genotype not associated with intravascular coagulation in Traumatic Brain Injury. Neurosci Lett 387(1): 28-31, Oct 2005. PMID: 16084020.
  • Iwata A, Browne KD, Chen X-H, Yuguchi T, Smith DH. Traumatic brain injury induces biphasic upregulation of ApoE and ApoJ protein in rats. J Neurosci Res. 82(1): 103-114, Oct 2005. PMID: 16118797.

2004

  • Stein SC, Smith DH. Coagulopathy in traumatic brain injury. Neurocrit Care. 1(4): 479-488, 2004. PMID: 16174954.
  • Maxwell WL, Pennington K, MacKinnon MA, Smith DH, McIntosh TK, Wilson JT, Graham DI. Differential responses in three thalamic nuclei in moderately disabled, severely disabled and vegetative patients after blunt head injury. Brain. 127: 2470-2478, Nov 2004. PMID: 15456707.
  • Lusardi TA, Rangan J, Sun D, Smith DH, Meaney DF. A device to study the initiation and propagation of calcium transients in cultured neurons after mechanical stretch. Ann Biomed Eng 32(11): 1546-1559, Nov 2004. PMID: 15636114.
  • Browne KD, Leoni MJ, Iwata A, Chen X-H, Smith DH. Acute treatment with MgSO4 attenuates long-term hippocampal tissue loss after brain trauma in the rat. J Neurosci Res. 77(6): 878-883, 2004. PMID: 15334605.
  • Pfister BJ, Iwata A, Meaney DF, Smith DH. Extreme stretch-growth of integrated axons. J Neurosci. 24(36): 7978-7983, Sep 2004. PMID: 15356212.
  • Chen X-H, Siman R, Iwata A, Meaney DF, Trojanowski JQ, Smith DH. Long-term accumulation of amyloid-_, _-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma. Am J Pathol. 165(2): 357-371, Aug 2004. PMID: 15277212. PMCID: PMC1618579.
  • Iwata A, Stys PK, Wolf JA, Chen X-H, Taylor AG, Meaney DF, Smith DH. Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors. J Neurosci. 24(19): 4605-4613, May 2004. PMID: 15140932.
  • Stein S, Graham DI, Chen X-H, Smith DH. Association between intravascular microthrombosis and cerebral ischemia in traumatic brain injury. Neurosurgery 54(4): 687-691, Mar 2004. PMID: 15028145.
  • Lusardi TA, Wolf JA, Putt ME, Smith DH, Meaney DF. Effect of acute calcium influx after mechanical stretch injury in vitro on the viability of hippocampal neurons. J Neurotrauma. 21(1):61-72, 2004. PMID: 14987466.
  • Stein S, Graham DI, Chen X-H, Smith DH. Association between intravascular microthrombosis and cerebral ischemia in traumatic brain injury. Neurosurgery. 54(3): 687-91, Mar 2004. PMID: 15028145.
  • Lusardi TA, Wolf JA, Putt ME, Smith DH, Meaney DF. Effect of acute calcium influx after mechanical stretch injury in vitro on the viability of hippocampal neurons. J Neurotrauma. 21(1): 61-72, Jan 2004. PMID: 14987466.

2003

  • Smith DH, Chen X-H, Iwata A, Graham DI. Amyloid-_ in axons after traumatic brain injury in humans. J Neurosurg. 98: 1072-1077, May 2003. PMID: 12744368.
  • Lusardi TA, Smith DH, Wolf JA, Meaney DF. The separate roles of calcium and mechanical forces in mediating cell death in mechanically injured neurons. Biorheology 40(1-3): 401-409, 2003. PMID: 12454433.
  • Smith DH, Meaney DF, Shull WH. Diffuse axonal injury in head trauma. J Head Trauma Rehabil. 18(4): 307-316, Jul-Aug 2003. PMID: 16222127.
  • Chen X-H, Iwata A, Nonaka M, Browne KD, Smith DH. Neurogenesis and glial proliferation persist for at least one year in the subventricular zone following brain trauma in rats. J Neurotrauma 20(7): 623-631, Jul 2003. PMID: 12908924.
  • Maxwell WL, Dhillon K, Harper L, Espin J, MacIntosh TK, Smith DH, Graham DI. There is differential loss of pyramidal cells from the human hippocampus with survival after blunt head injury. J Neuropathol Exp Neurol. 62(3): 272-279, Mar 2003. PMID: 12638731.
  • Saatman KE, Abai B, Grosvenor A, Vorwerk C, Smith DH, Meaney DF. Traumatic Axonal Injury Results in Biphasic Calpain Activation and Retrograde Transport Impairment in Mice. J Cereb Blood Flow Metab. 23(1): 34-42, Jan 2003. PMID: 12500089.
  • Smith DH, Uryu K, Saatman KE, Trojanowski JQ, McIntosh TK. Protein accumulation in traumatic brain injury. Neuromolecular Med. 4(1-2): 59-72, 2003. PMID: 14528053.
  • Lusardi TA, Smith DH, Wolf JA, Meaney DF. The separate roles of calcium and mechanical forces in mediating cell death in mechanically injured neurons. Biorheology. 40 (1-3): 401-409, 2003. PMID: 12454433.

2002

  • Stein SC, Chen X-H, Sinson GP, Smith DH. Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury. J Neurosurg. 97(6): 1373-1377, Dec 2002. PMID: 12507136.
  • Iwata A, Chen X-H, McIntosh TK, Browne KD, Smith DH. Long-term accumulation of amyloid-_ in axons following brain trauma in rats without persistent upregulation of amyloid precursor protein genes. J Neuropathol Exp Neurol. 61(12): 1056-1068, Dec 2002. PMID: 12484568.
  • Smith DH, Meaney DF. Roller Coasters, G Forces, and Brain Trauma: On the Wrong Track? J Neurotrauma. 19(10): 1117-1120, Oct 2002. PMID: 12427321.

2001

  • Smith DH, Wolf JA, Meaney DF. A new strategy to produce sustained growth of central nervous system axons: Continuous mechanical tension. Tissue Eng. 7(2): 131-139, Apr 2001. PMID: 11304449.
  • Wolf JA, Stys PK, Lusardi T, Meaney DF, Smith DH. Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels. J Neurosci. 21(6): 1923-1930, Mar 2001. PMID: 11245677.

2000

  • Smith DH, Meaney DF. Axonal damage in traumatic brain injury. Neuroscientist. 6(6): 483-495, Dec 2000.
  • Leoni MJ, Chen X-H, Mueller AL, Cheney J, McIntosh TK, Smith DH. NPS 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat. Exp Neurol. 166(2): 442-449, Dec 2000. PMID: 11085909.
  • Smith DH, Nonaka M., Miller R, Leoni M, Chen X-H, Alsop D, Meaney DF. Immediate coma following inertial brain injury dependent on axonal damage in the brainstem. J Neurosurg. 93(2): 315-322, Aug 2000. PMID: 10930019.
  • Nakagawa Y, Reed L, Nakamura M, McIntosh TK, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Lee VM-Y, Trojanowski JQ. Brain trauma in aged transgenic mice induces regression of established Aβ deposits. Exp Neurol. 163(1): 244-52, May 2000. PMID: 10785464.

1999

  • Nonaka M, Chen X-H, Pierce JES, Leoni MJ, McIntosh TK, Wolf JA, Smith DH. Prolonged activation of NF-kappaB following traumatic brain injury in rats. J Neurotrauma. 16(11): 1023-1034, Nov 1999. PMID: 10595819.
  • Smith DH, Chen X-H, Nonaka M, Trojanowski JQ, Lee VMY, Saatman KE, Leoni MJ, Xu BN, Wolf JA, Meaney DF. Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig. J Neuropathol Exp Neurol. 58(9): 982-992, Sep 1999. PMID: 10499440.
  • Nakagawa Y, Nakamura M, McIntosh TK, Rodriguez A, Berlin JA, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Schmidt ML, Lee VMY, Trojanowski JQ. Traumatic brain injury in young, amyloid-β peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished A beta deposition during aging. J Comp Neurol. 411(3): 390-398, Aug 1999. PMID: 10413774.
  • Smith DH, Wolf JA, Lusardi TA, Lee VMY, Meaney DF. High tolerance and delayed elastic response of cultured axons to dynamic stretch injury. J Neurosci. 19(11): 4263-4269, Jun 1999. PMID: 10341230.
  • Chen X-H, Meaney DF, Xu BN, Nonaka M, McIntosh TK, Wolf JA, Saatman KE, Smith DH. Evolution of neurofilament subtype accumulation in axons following diffuse brain injury in the pig. J Neuropathol Exp Neurol. 58(6): 588-596, Jun 1999. PMID: 10374749.
  • McGowan JC, McCormack TM, Grossman RI, Mendoca R, Chen X-H, Berlin JA, Meaney DF, Xu BN, Cecil KM, McIntosh TK, Smith DH. Diffuse axonal pathology detected with magnetization transfer imaging following brain injury in the pig. Magn Reson Med. 41(4): 727-733, Apr 1999. PMID: 10332848.
  • Shreiber DI, Bain AC, Ross DT, Smith DH, Gennarelli TA, McIntosh TK, Meaney DF. Experimental investigation of cerebral contusion: Histopathological and immunohistochemical evaluation of dynamic cortical deformation. J Neuropathol Exp Neurol. 58(2): 153-164, Feb 1999. PMID: 10029098.
  • Shreiber DI, Smith DH, Meaney DF. Immediate in vivo response of the cortex and the blood-brain barrier following dynamic cortical deformation in the rat. Neurosci Lett. 259(1): 5-8, 4 Jan 1999. PMID: 10027542.

1998

  • Miller RT, Margulies SS, Leoni M, Nonaka M, Chen X-H, Smith DH, Meaney DF. Finite element modeling approaches for predicting injury in an experimental model of severe diffuse axonal injury. SAE Transactions. Society of Automotive Engineers, 107(6): 155-167, 1998 Notes: (p-337) 983154.
  • Pierce JES, Smith DH, Trojanowski JQ, McIntosh TK. Enduring cognitive, neurobehavioral, and histopathological changes persist for up to one year following experimental brain injury in rats. Neuroscience. 87(2): 359-369, Nov 1998. PMID: 9740398.
  • Smith DH, Nakamura M, McIntosh TK, Wang J, Rodriguez A, Chen X-H, Raghupathi R, Saatman KE, Clemens J, Schmidt ML, Lee VY-M, Trojanowski JQ. Brain trauma induces massive hippocampal neuron death linked to a surge in _-Amyloid levels in mice overexpressing mutant amyloid precursor protein. Am J Pathol. 153(3): 1005-1010, Sep 1998. PMID: 9736050. PMCID: PMC1853010.
  • Smith DH, Cecil KM, Meaney DF, Chen X-H, McIntosh TK, Gennarelli TA, Lenkinski RE. Magnetic resonance spectroscopy of diffuse brain trauma in the pig. J Neurotrauma. 15(9): 665-674, Sep 1998. PMID: 9753214.
  • McIntosh TK, Saatman KE, Raghupathi R, Graham DI, Smith DH, Lee VMY, Trojanowski JQ. The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms. Neuropathol Appl Neurobiol. 24(4): 251-267, Aug 1998. PMID: 9775390.
  • Zhang C, Raghupathi R, Saatman KE, Smith DH, Stutzmann J-M, Wahl F, McIntosh TK. Riluzole attenuates cortical lesion size, but not hippocampal neuronal loss, following traumatic brain injury in the rat. J Neurosci Res. 52(3): 342-349, May 1998. PMID: 9590442.
  • Okiyama K, Smith DH, White WF, McIntosh TK. Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat. Brain Res 792(2): 291-298, May 1998. PMID: 9593949.
  • Cecil KM, Lenkinski RE, Meaney DF, McIntosh TK, Smith DH. High-field proton magnetic resonance spectroscopy of a swine model for axonal injury. J Neurochem. 70(5): 2038-2044, May 1998. PMID: 9572290.
  • Cecil KM, Hills EC, Sandel ME, Smith DH, McIntosh TK, Mannon LJ, Sinson GP, Bagley LJ, Grossman RI, Lenkinski RE. Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients. J Neurosurg. 88(5): 795-801, May 1998. PMID: 9576245.
  • Murai H, Pierce JES, Raghupathi R, Smith DH, Saatman KE, Trojanowski JQ, Lee VM-Y, Loring JF, Eckman C, Younkin S, McIntosh TK. Two-fold overexpression of human _-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury. J Comp Neurol. 392(4): 428-438, Mar 1998. PMID: 9514508.

1997

  • Smith DH, Chen X-H, Pierce JES, Wolf JA, Trojanowski JQ, Graham DI, McIntosh TK. Progressive atrophy and neuron death for one year following brain trauma in the rat. J Neurotrauma. 14(10): 715-727, Oct 1997. PMID: 9383090.
  • Saatman KE, Contreras PC, Smith DH, Raghupathi R, McDermott KL, Fernadez SC, Sanderson KL, Voddi M, McIntosh TK. Insulin-like growth factor-1 (IGF-1) improves both neurological motor and cognitive outcome following experimental brain injury. Exp Neurol. 147(2): 418-427, Oct 1997. PMID: 9344566.
  • Smith DH, Perri BR, Ragupathi R, Saatman KE, McIntosh TK. Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat. Neurosci Lett. 231(3): 135-138, Aug 1997. PMID: 9300640.
  • Smith DH, Chen X-H, Xu B-N, McIntosh TK, Gennarelli TA, Meaney DF. Characterization of diffuse axonal pathology and selective hippocampal damage following inertial brain trauma in the pig. J Neuropathol Exp Neurol. 56(7): 822-834, Jul 1997. PMID: 9210879.
  • Rubin Y, Cecil K, Wehrli S, McIntosh TK, Lenkinski RE, Smith DH. High resolution 1H NMR spectroscopy following experimental brain trauma. J Neurotrauma. 14(7): 441-449, Jul 1997. PMID: 9257662.
  • Okiyama K, Smith DH, White WF, Richter K, McIntosh TK. Effects of the novel NMDA antagonists CP-98,113, CP-101,581, and CP-101,606 on cognitive function and regional cerebral edema following experimental brain injury in the rat. J Neurotrauma. 14(4): 211-222, Apr 1997. PMID: 9151770.
  • McDermott KL, Raghupathi R, Fernandez SC, Saatman KE, Protter AA, Finklestein SP, Sinson G, Smith DH, McIntosh TK. Delayed administration of basic fibroblast growth factor (bFGF) attenuates cognitive dysfunction following parasagittal fluid percussion brain injury in the rat. J Neurotrauma. 14(4): 191-200, Apr 1997. PMID: 9151768.
  • Perri BR, Smith DH, Murai H, Sinson G, Saatman KE, Raghupathi R, Bartus RT, McIntosh TK. Metabolic quantification of lesion volume following experimental traumatic brain injury in the rat. J Neurotrauma. 14(1): 15-22, Jan 1997. PMID: 9048307.

1996

  • McIntosh TK, Smith DH, Voddi M, Perri BR, Stutzman J-M. Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat. J Neurotrauma. 13(12): 767-780, Dec 1996. PMID: 9002062.
  • Alsop DC, Murai H, Detre JA, McIntosh TK, Smith DH. Detection of acute pathologic changes following experimental traumatic brain injury using diffusion-weighted magnetic resonance imaging. J Neurotrauma. 13(9): 515-521, Sep 1996. PMID: 8913968.
  • Rosenkrantz TS, Kubin J, Mishra OP, Smith DH, Delivoria-Papadopoulos M. Brain cell membrane Na+,K(+)-ATPase activity following severe hypoxic injury in the newborn piglet. Brain Res. 730(1-2): 52-57, Aug 1996. PMID: 8883888.
  • Kimura H, Meaney DF, McGowan JC, Grossman RI, Lenkinski RE, Ross DT, McIntosh TK, Gennarelli TA, Smith DH. Magnetization transfer imaging of diffuse axonal injury following experimental brain injury in the pig: characterization by magnetization transfer ratio with histopathologic correlation. J Comput Assist Tomogr. 20(4): 540-546, Jul/Aug 1996. PMID: 8708052. Notes: Editors Award for Excellence.
  • McIntosh TK, Smith DH, Garde E. Therapeutic approaches for the prevention of secondary brain injury. Eur J of Anaesthesiol. 13(3): 291-309, May 1996. PMID: 8737120.
  • Saatman KE, Murai H, Bartus RT, Smith DH, Hayward NJ, Perri BR, McIntosh TK. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat. Proc Natl Acad Sci USA. 93(8): 3428-3433, Apr 1996. PMID: 8622952. PMCID: PMC39625.
  • Fan L, Young PR, Barone FC, Feuerstein GZ, Smith DH, McIntosh TK. Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS. Brain Res Mol Brain Res. 36(2): 287-291, Mar 1996. PMID: 8965649.
  • Raghupathi R, Smith DH, Saatman KE, McIntosh TK. Temporal alterations in the immunoreactivity of anti-cell death proteins following traumatic brain injury. J Neurosurg. 84(2): 847, Feb 1996. PMID: 12803975. PMCID: PMC2590756.
  • Pierce JES, Trojanowski JQ, Graham DI, Smith DH, McIntosh TK. Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and beta-amyloid peptide after experimental brain injury in the rat. J Neurosci. 16(3): 1083-1090, Feb 1996. PMID: 8558237.
  • McIntosh TK, Smith DH, Meaney DF, Kotapka MJ, Gennarelli TA, Graham DI. Neuropathological sequelae of traumatic brain injury: Relationship to neurochemical and biomechanical mechanisms. Lab Invest. 74(2): 315-342, Feb 1996. PMID: 8780153.
  • Hicks R, Soares H, Smith DH, McIntosh TK. Temporal and spatial characterization of neuronal injury following lateral fluid-percussion brain injury in the rat. Acta Neuropathol. 91(3): 236-246, Jan 1996. PMID: 8834535.

1995

  • Soares HD, Hicks RR, Smith D, McIntosh TK. Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury. J Neurosci. 15(12): 8223-8233, Dec 1995. PMID: 8613756.
  • McIntosh TK, Smith DH. Therapeutic strategies in current clinical trials. Journal of Head Trauma Rehabilitation. 10(6): 1-6, Dec 1995.
  • Rubin Y, LaPlaca MC, Smith DH, Thibault LE, Lenkinski RE. The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons. Neurosci Lett. 198(3): 209-212, Oct 1995. PMID: 8552323.
  • Raghupathi R, McIntosh TK, Smith DH. Cellular responses to experimental brain injury. Brain Pathol. 5(4): 437-442, Oct 1995. PMID: 8974626.
  • Smith DH, Meaney DF, Lenkinski RE, Alsop DC, Grossman R, Kimura H, McIntosh TK, Gennarelli TA. New magnetic resonance imaging techniques for the evaluation of traumatic brain injury. J Neurotrauma. 12(4): 573-577, Aug 1995. PMID: 8683608.
  • Meaney DF, Smith DH, Shreiber DI, Bain AC, Miller R, Ross DT, Gennarelli TA. Biomechanical analysis of experimental diffuse axonal injury. J Neurotrauma. 12(4): 689-694, Aug 1995. PMID: 8683620.
  • Fan L, Young PR, Barone FC, Feuerstein GZ, Smith DH, McIntosh TK. Experimental brain injury induces expression of interleukin-1-beta mRNA in the rat brain. Brain Res Mol Brain Res. 30(1): 125-130, May 1995. PMID: 7609633.
  • Smith DH, Soares HD, Pierce JES, Perlman KG, Saatman KE, Meaney DF, Dixon CE, McIntosh TK. A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects. J Neurotrauma. 12(2): 169-178, Apr 1995. PMID: 7629863.
  • Hicks RR, Smith DH, McIntosh TK. Temporal response and effects of excitatory amino-acid antagonism on microtubule-associated protein-2 immunoreactivity following experimental brain injury in rats. Brain Res. 678(1-2): 151-160, Apr 1995. PMID: 7620884.
  • Smith DH, Gennarelli TA, McIntosh TK. The potential of 21-aminosteroids (lazaroids) as neuroprotective therapies in CNS injuries. CNS Drugs 3(3): 159-164, Mar 1995.
  • Okiyama K, Smith DH, Gennarelli TA, Simon RP, Leach M, McIntosh TK. The sodium channel blocker and glutamate release inhibitor BW1003C87 and magnesium attenuate regional cerebral edema following experimental brain injury in the rat. J Neurochem. 64(2): 802-809, Feb 1995. PMID: 7830074.

1994

  • Meaney DF, Smith DH, Shreiber DI, Rahdert DA, Bogen DK, Ross DT, McIntosh TK, Gennarelli TA. Prediction of experimental diffuse axonal injury severity using macroscopic head motion parameters. Proced Assoc Adv Automotive Med 38: 345-357, Sep 1994.
  • Hicks RR, Smith DH, Gennarelli TA, McIntosh TK. Kynurenate is neuroprotective following experimental brain injury in the rat. Brain Res. 655(1-2): 91-96, Aug 1994. PMID: 7812795.
  • Ross DT, Meaney DF, Sabol MK, Smith DH, Gennarelli TA. Distribution of forebrain diffuse axonal injury following inertial closed head injury in miniature swine. Exp Neurol. 126(2): 291-299, Apr 1994. PMID: 7925827.
  • Smith DH, Lowenstein DH, Gennarelli TA, McIntosh TK. Persistent memory dysfunction is associated with bilateral hippocampal damage following experimental brain injury. Neurosci Lett. 168(1-2): 151-154, Feb 1994. PMID: 8028769.
  • Okiyama K, Rosenkrantz TS, Smith DH, Gennarelli TA, McIntosh TK. (S)-emopamil attenuates acute reduction in regional cerebral blood flow following experimental brain injury. J Neurotrauma. 11(1): 83-95, Feb 1994. PMID: 8201628.

1993

  • Smith DH, Okiyama K, Thomas MJ, McIntosh TK. Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury. J Neurosci. 13(12): 5383-5392, Dec 1993. PMID: 8254381.
  • Hicks RR, Smith DH, Lowenstein DH, Saint Marie RL, McIntosh TK. Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus. J Neurotrauma. 10(4): 405-414, Winter 1993. PMID: 8145264.
  • Pierce JES, Smith DH, Eison MS, McIntosh TK. The nootropic compound BMY-21502 improves spatial learning ability in brain injured rats. Brain Res 624(1-2): 199-208, Oct 1993. PMID: 8252392.
  • Smith DH, Okiyama K, Gennarelli TA, McIntosh TK. Magnesium and ketamine attenuate cognitive dysfunction following experimental brain injury. Neurosci Lett. 157(2): 211-214, Jul 1993. PMID: 8233056.

1992

  • Lowenstein DH, Thomas MJ, Smith DH, McIntosh TK. Selective vulnerability of dentate hilar neurons following traumatic brain injury: A potential mechanistic link between head trauma and disorders of the hippocampus. J Neurosci. 12(12): 4846-4853, Dec 1992. PMID: 1464770.
  • Okiyama K, Smith DH, Thomas MJ, McIntosh TK. Evaluation of a novel calcium channel blocker, (S)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury. J Neurosurg. 77(4): 607-615, Oct 1992. PMID: 1527621.
  • Prasad MR, Tzigaret C, Smith DH, Soares HD, McIntosh TK. Decreased alpha 1-adrenergic receptors after experimental brain injury. J Neurotrauma. 9(3): 269-279, Fall 1992. PMID: 1335519.
  • McIntosh TK, Thomas MJ, Smith DH, Banbury M. The novel 21-aminosteroid U74006F attenuates cerebral edema and improves survival after brain injury in the rat. J Neurotrauma. 9(1): 33-46, Spring 1992. PMID: 1619674.

1991

  • Smith DH, Okiyama K, Thomas MJ, Claussen B, McIntosh TK. Evaluation of memory dysfunction following experimental brain injury using the Morris Water Maze. J Neurotrauma. 8(4): 259-270, Winter 1991. PMID: 1803034.