Penn Medicine Neuroscience Center: Multiple Sclerosis Center
 
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Clinical Trials and Research

Multiple Sclerosis

Shaping the Future of MS Treatment
Research teams in the Penn MS program lead clinical and laboratory-based research programs that are recognized at both regional and international levels for their contributions to the advancement of MS treatment. Research projects are sponsored by the National Institutes of Health (NIH), the National MS Society, and industry, and include the following areas of focus:

  • International treatment trials to determine the efficacy of current and novel therapies for patients at all phases of MS, including first demyelinating events, relapsing-remitting, secondary-progressive, and primary progressive MS.
  • In collaboration with Penn Neuroradiology, investigations are ongoing to evaluate multimodal MRI, diffusion-tensor imaging, and other modalities as measures of MS disease location and activity within the brain and spinal cord.
  • Collaborative efforts between neuro-ophthalmologists and MS clinicians to validate and implement new visual outcome measures. These studies provide key findings that will establish the visual pathways as a model for studying neuroprotective therapies. ß World-class laboratory-based research programs in neurovirology and immunology are providing insight into our understanding of potential causes for MS on a cellular level, building a foundation for future drug development.
  • In collaboration with the Children’s Hospital of Philadelphia, clinical outcome measures for vision and neurologic function are being evaluated at Penn to establish their role and use in the pediatric population to facilitate development of clinical trials in pediatric MS.

 

 


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