Penn Lung Center

Acute Lung Injury and Pulmonary Endothelial/Neutrophil Cell Biology

A multidisciplinary group of basic science and clinical investigators work together to study the pathogenesis and treatment of acute lung injury. Funded by a program project and a number of RO1 grants, a focus of this group has been oxidant injury and ischemia/reperfusion injury.

Specific faculty interests include:

Steven M. Albelda, MD

  • Role of Cell Adhesion Molecules in Lung Injury
  • Role of Oxidants in Development of ARDS

Jason Christie, MD, MSCE

  • Molecular Epidemiology of Acute Lung Injury
  • Role of Oxidants in Development of ARDS
  • Predictors of post-transplant lung injury
  • Outcomes after ARDS

Melpo Christofidou-Solomidou, PhD

  • Investigation of targeted antioxidant approaches to acute lung disease  
  • Investigation of the usefulness of novel utritional agents with antioxidant properties in acute and chronic lung disease

Horace Delisser, MD

  • Role of PECAM-1 in angiogenesis and tumor cell metastasis
  • Role of hyaluronan receptors (RHAMM and CD44) in angiogenesis
  • Role of cell adhesion molecules in post-natal lung development

Aron Fisher, MD

  • Role of anti-oxidant enzymes in lung injury
  • Surfactant Biology

Barry Fuchs, MD

  • Improving ICU outcomes

Paul Lanken, MD

  • ARDS clinical trials
  • Bioethics in the ICU

Nilam Mangalmurti, MD

  • Mechanisms of acute lung injury in red blood cell transfusions

Nuala Meyer, MD

  • Genetic mechanisms of acute lung injury
  • Developing a cohort of sepsis patients for genetic epidemiology study

Vladimir Muzykantov, MD, PhD

  • Lung drug delivery using nanoparticles
  • Role of oxidants in endothelial cell signal transduction

Scott Worthen, MD

  • Mechanisms of lung neutrophil recruitment and activation