Penn Cardiovascular Institute

Symposium on Translational Science and Emerging Therapy for Heart Failure

2013 CVI Heart Failure Symposium

Wednesday, May 15, 2013

Arthur H. Rubenstein Auditorium & Lobby
Smilow Center for Translational Research
3400 Civic Center
Philadelphia, PA 19104

Registration for the symposium is CLOSED

Symposium Agenda:

8:00 AM Continental Breakfast - Lobby
Registrants and Invited Speakers
8:30 AM Opening Remarks and Introductions
Thomas A. Cappola, MD, Sc.M.
8:40 to 11:15 AM Novel Signaling to Novel Treatments

Regulation of myofibroblast formation and tissue fibrosis and wound healing through TRPC6-Calcineurin signaling
Jeffery D. Molkentin, PhD
Cincinnati Children's Hospital Medical Center

Heart Failure - A PGKarious Balancing Act
David A. Kass, MD
The Johns Hopkins University Medical Institutions

Translational Efforts in Heart Failure with Preserved Ejection Fraction
Margaret Redfield, MD
Mayo Clinic, Cardiorenal Laboratory
11:15 to 11:20 AM Break
11:25 to 12:30 PM Chemotherapy Cardiotoxicity: Mechanisms and Treatments

Tnni3K: A pro-death cardiomyocyte-specific ROS generator
Thomas Force, MD
Temple University School of Medicine

Cardiotoxicity of Cancer Therapeutics
Bonnie Ky, MD, MSCE
University of Pennsylvania, Perelman School of Medicine
12:30 to 1:50 PM Lunch and poster session judging — Lobby
Registrants and Invited Speakers
1:50 PM Remarks and Introductions
Kenneth B. Margulies, MD
2:00 to 3:10 PM Targeting Metabolism and Mitochondrial Defects

Metabolic Stress as Cause for Dysfunctional Protein Homeostasis in Failing Heart
Heinrich Taegtmeyer, MD, DPhil
The University of Texas Medical School at Houston

TFAM mediates resistance to oxidative stress through protective packaging of mitochondrial DNA
Brett Kaufman, PhD
University of Pennsylvania, Perelman School of Medicine
3:15 to 5:00 PM Systems Biology and Genomics for Target Discovery

A Novel Approach to Unraveling the Genetic Basis of Heart Failure: Gene Module Association Study
James N.Weiss, MD
David Geffen School of Medicine at UCLA

Integrative Genomics of the Heart
Kenneth B. Margulies, MD and Thomas A. Cappola, MD, Sc.M.
University of Pennsylvania, Perelman School of Medicine
5:00 PM Closing Remarks
Michael S. Parmacek, MD
5:15 to 6:30 PM Reception — Lobby
Registrants and Invited Speakers