Penn Cardiovascular Institute

Kahn Lab

Contact the Lab

Mark L. Kahn, MD, BA

Mark L. Kahn, MD, BA
Principal Investigator

Mark L. Kahn, MD, BA
11-123 Smilow Center for Translational Research
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-9007
Office: 215-898-5001
Fax: 215-573-2094
markkahn@mail.med.upenn.edu
http://www.med.upenn.edu/kahnlab/

Patricia Mericko
Laboratory Manager, Kahn lab
Rm. 11-101A, Lab; 11-184
Smilow Center for Translational Research
3400 Civic Center Boulevard, Bldg. 421
Philadelphia, PA 19104-5159
Office: 215-573-7069
Fax: 215-573-7884
pmericko@mail.med.upenn.edu
http://www.med.upenn.edu/kahnlab

Overview

The Kahn Lab investigates the signaling pathways that regulate vascular biology and disease, with an interest in both lymphatic and blood vessel regulatory pathways, and in the interactions between blood cells and vascular endothelium. Many of the pathways investigated are known to cause human vascular diseases. The Kahn Lab applies vertebrate genetic approaches to understanding the function of those pathways during normal development and in disease models, primarily through the use of mouse genetic models for in vivo studies. Zebrafish studies and avian models are also incorporated to complement the mouse models.

Research Projects

The major areas of research in the Kahn Lab include:

Lymphatic Vascular Biology

The Kahn Lab is deeply invested in understanding the signaling pathways and functional roles of the lymphatic vascular network. In contrast to blood vessel development and growth, relatively little is understood regarding the mechanisms that control lymphatic vessel growth. Active projects in this area in the lab are described below.

  • Regulation of blood-lymphatic vascular separation by PODOPLANIN-CLEC2 signaling.
  • Control of lymphangiogenesis by CCBE1.

Blood Vascular Biology

The Kahn Lab is actively investigating a number of signaling pathways that regulate blood vessel growth, with an emphasis on more recently discovered pathways that are known to cause human disease.

  • Cerebral Cavernous Malformation (CCM) signaling.
  • Regulation of vascular function by fluid shear forces.

Members

  • Mark Kahn, MD
  • Zhiying Zou, PhD
  • Xiangjian Zheng, PhD
  • David Enis, MD, PhD
  • Cynthia Myers, MD
  • Zoltan Jakus, MD, PhD
  • Yiqing Yang, PhD
  • Wei Pan, PhD
  • Daniel Sweet, PhD
  • David Rawnsley, MD
    PhD Student
  • Paul Hess, MD
    PhD Student
  • Zinan Zhou
    PhD Student
  • Hung Manh Bui
    PhD Student
  • Mei Chen, BS
  • Aslihan Sen, BS
  • Veerpal Dhillon, BS
  • Vinayak Kumar, BS
    MS Student
  • Jeremy Chang, BS
    MS Student
  • Patricia Mericko-Ishizuka, MS

Selected Publications

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