Penn Cardiovascular Institute

Goncharova Lab

Contact the Lab

Elena Goncharova, PhD

Elena A. Goncharova, PhD
Principal Investigator

Elena A. Goncharova, PhD
Translational Research Laboratories Rm 1214
125 South 31st Street
Philadelphia, PA 19104
215-746-3593
goncharo@mail.med.upenn.edu

Overview

The Goncharova Lab focuses upon the signaling mechanisms of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), specifically on the role of mammalian target of rapamycin (mTOR) in metabolism, proliferation, and survival of pulmonary vascular smooth muscle cells in PAH.

Research Projects

The Goncharova Lab focuses upon the signaling mechanisms of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), specifically on the role of mammalian target of rapamycin (mTOR) in metabolism, proliferation, and survival of pulmonary vascular smooth muscle cells in PAH.

mTOR acts through two functionally distinct complexes, mTORC1 (mTOR-raptor) and mTORC2 (mTOR-rictor). Recent investigations at the Lab have shown that both mTORC1 and mTORC2 signaling pathways are required for proliferation of pulmonary arterial vascular smooth muscle cells under chronic hypoxia, a recognized trigger of pulmonary vascular disease. The specific roles of mTORC1 and mTORC2 in human PAH continue to be explored by using a combination of human PAH specimens with conditional mouse mutants to determine how mTORC1 and mTORC2 regulate pulmonary arterial vascular smooth muscle cell metabolism, growth and survival. The Lab also performs pre-clinical testing of mTOR kinase inhibitors using human PAH cells and the rat chronic hypoxia model of pulmonary hypertension.

Selected Publications

The Goncharova Lab publishes research findings in a variety of clinical journals.

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