Penn Cardiovascular Institute

Davies Lab

Contact the Lab

Peter Francis Davies

Peter Francis Davies, PhD
Principal Investigator

To inquire about the availability of postdoctoral positions, contact Professor Davies.

Peter F. Davies, PhD
Director, Interdisciplinary Cardiovascular NIH Training Grant
Co-Director, Penn HHMI-NIBIB Interfaces Program
1010 Vagelos Building
3340 Smith Walk
215-573-6813
Fax: 215-573-6815
pfd@mail.med.upenn.edu

Overview

The Davies Lab is interested in fundamental mechanisms of cardiovascular cell and tissue biomechanics, biochemistry and molecular biophysics. Our particular interest is primarily the endothelial cell which we study in vivo and in reductionist experiments in vitro with the objective of understanding the interplay between hemodynamics (blood flow) and endothelium in cardiovascular physiology and pathology.

Research Projects

Endothelial susceptibility to the initiation of atherosclerosis associated with complex blood flow.

Studies of spatial endothelial phenotypes in vivo (swine model). Transcriptional, translational and functional cell profiles and their regulation by transcription factors, small RNAs (microRNAs, long non-coding RNAs) and epigenomic modifications (DNA methylation, acetylation and histone modifications). Profiling in vivo informs the design of reductionist experiments in vitro to identify mechanisms.


Design improvements in vascular stents.

Computational and experimental fluid dynamics. Bench top experiments to test the effect of changes in stent strut geometries upon flow patterns, and the consequences for endothelial phenotype and thrombotic risk. Aimed at modifying stent geometry to reduce late stent thrombosis.

Members

The Davies Lab is comprised of doctoral and post-doctoral researchers, research specialists and graduate students.

  • Juan M. Jimenez PhD (Princeton), Research Associate in Pathology; K25 Awardee
  • Yizhou Jiang PhD (Univ Wisconsin-Madison), Postdoctoral Researcher
  • Maggie McCormick PhD (Univ North Carolina), Postdoctoral Researcher
  • Congzhu Shi PhD Senior Research Specialist
  • Yuxiang Zhang MS (UPenn) PhD-Student in Pharmacology
  • Kristy Ou (UCLA) PhD-Student in Pharmacology
  • Ian Johnston (Rutgers), Pharmacology Graduate Student
  • Chris Kampmeyer, Masters Student (Vagelos Scholar Chemistry/Biochemistry)
  • Peijang Wang (Shanghai Jiao Tong University-University of Michigan Joint Institution), Masters Bio-Engineering Student
  • Michael Yu, Bioengineering undergraduate Intern
  • Jessica Herrmann, High School Senior Summer Intern

Key Collaborators

  • Elisabetta Manduchi PhD Computational Biology and Informatics Lab, Penn Center for Bioinformatics
  • Chris Stoeckert PhD Computational Biology and Informatics Lab, Penn Center for Bioinformatics
  • William Pritchard MD PhD Center for Devices & Radiological Health, US FDA
  • John Karanian PhD Center for Devices & Radiological Health, US FDA

Recent Publications

Members of the Davies Lab of the Penn Cardiovascular Institute publish journal articles and book chapters that reflect the breadth of the laboratory's research.