Penn Heart and Vascular

Clinical Trials at the Preventive Cardiovascular Program

Clinical Trials

Continuing a long tradition of research and pioneering advances in preventive cardiovascular medicine, we lead the development and evaluation of novel therapeutic, diagnostic, and prognostic approaches to atherosclerotic disease. Patients may be eligible for any clinical trial if certain criteria is met.

Clinical trials currently enrolling patients include:

Abnormal LDL-cholesterol

Evaluation of Abnormal Plasma Lipid Levels
National Characterization of Patients with Severe Hypercholesterolemia
Characterizing PCSK9 in Patients Eligible for LDL Apheresis
Efficacy, Safety and Tolerability of Pf-04950615 for Hypercholesterolemia

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Abnormal HDL-cholesterol

Evaluation of Abnormal Plasma Lipid Levels
National Characterization of Patients with Severe Hypercholesterolemia
Characterizing PCSK9 in Patients Eligible for LDL Apheresis
Efficacy, Safety and Tolerability of Pf-04950615 for Hypercholesterolemia
Safety and Efficacy of REGN727 in Familial Hypercholesterolemia
Biochemical Characteristics of Elevated HDL and Coronary Heart Disease
Mechanistic Study of HDL Kinetics in Patients with Elevated HDL
Genetics of High HDL
Effect of Low HDL on Blood Sugar

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Abnormal triglycerides

Evaluation of Abnormal Plasma Lipid Levels
Efficacy and Safety of Epanova® in Severe Hypertriglyceridemia

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Heart attack / Coronary disease

Biochemical Characteristics of Elevated HDL and Coronary Heart Disease
Mechanistic Study of HDL Kinetics in Patients with Elevated HDL
Assessment of Vascular Health after Niacin Therapy
The Complex Genetics Initiative

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Peripheral vascular disease

Assessment of Vascular Health after Niacin Therapy
Sodium Nitrite in Diabetic Patients with Peripheral Artery Disease
Genetic Information to Guide Anticoagulation Therapy
Safety and Efficacy of GSK1278863 for Peripheral Artery Disease
Genetic Causes of Varicose Veins
MRI Examination for Peripheral Artery Disease

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Diabetes / High blood glucose

Sodium Nitrite in Diabetic Patients with Peripheral Artery Disease
Penn Diabetes Heart Study

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High blood pressure

Lifestyle Modification in Blood Pressure Study (LIMBS)

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Psoriasis cardiovascular evaluation

A Descriptive Study to Evaluate Cardiometabolic Risk Factors in Patients with Psoriasis (PSO-D)
A Descriptive Study to Evaluate Subclinical Atherosclerosis by FDG PET CT in Patients with Psoriasis, Rheumatoid Arthritis and Psoriatic Arthritis (PSO-CVD)
The Vascular Inflammation in Psoriasis Trial (VIP)
The Vascular Inflammation in Psoriasis Trial in patients treated with Ustekinumab (VIP-2)

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