Clinical Trials
Continuing a long tradition of research and pioneering advances in preventive cardiovascular medicine, we lead the development and evaluation of novel therapeutic, diagnostic, and prognostic approaches to atherosclerotic disease. Patients may be eligible for any clinical trial if certain criteria is met.
Clinical trials currently enrolling patients include:
- Abnormal LDL-cholesterol
- Abnormal HDL-cholesterol
- Abnormal triglycerides
- Heart attack / Coronary disease
- Peripheral vascular disease
- Diabetes / High blood glucose
- High blood pressure
- Psoriasis cardiovascular evaluation
Abnormal LDL-cholesterol
- Evaluation of Abnormal Plasma Lipid Levels
-
- Principal investigator: Dr. Daniel J. Rader
- Contact: Marjorie Risman, risman@mail.med.upenn.edu
- National Characterization of Patients with Severe Hypercholesterolemia
-
- Principal investigator: Dr. Daniel J. Rader
- Contact: Jennifer Morrissey, jennifer.morrissey@uphs.upenn.edu
- Characterizing PCSK9 in Patients Eligible for LDL Apheresis
-
- Principal investigator: Dr. Daniel J. Rader
- Contact: Marjorie Risman, risman@mail.med.upenn.edu
- Efficacy, Safety and Tolerability of Pf-04950615 for Hypercholesterolemia
-
- Principal investigator: Dr. Emil M. DeGoma
- Contact: Laura Pollan, pollan@mail.med.upenn.edu
Abnormal HDL-cholesterol
- Evaluation of Abnormal Plasma Lipid Levels
-
- Principal investigator: Dr. Daniel J. Rader
- Contact: Marjorie Risman, risman@mail.med.upenn.edu
- National Characterization of Patients with Severe Hypercholesterolemia
-
- Principal investigator: Dr. Daniel J. Rader
- Contact: Jennifer Morrissey, jennifer.morrissey@uphs.upenn.edu
- Characterizing PCSK9 in Patients Eligible for LDL Apheresis
-
- Principal investigator: Dr. Daniel J. Rader
- Contact: Marjorie Risman, risman@mail.med.upenn.edu
- Efficacy, Safety and Tolerability of Pf-04950615 for Hypercholesterolemia
-
- Principal investigator: Dr. Emil M. DeGoma
- Contact: Laura Pollan, pollan@mail.med.upenn.edu
- Safety and Efficacy of REGN727 in Familial Hypercholesterolemia
-
- Principal investigator: Emma A. Meagher
- Contact: Anna Raper, raper@mail.med.upenn.edu
- Biochemical Characteristics of Elevated HDL and Coronary Heart Disease
-
- Principal investigator: Dr. Marina Cuchel
- Contact: Marjorie Risman, risman@mail.med.upenn.edu
- Mechanistic Study of HDL Kinetics in Patients with Elevated HDL
-
- Principal investigator: Dr. Marina Cuchel
- Contact: Amanda Baer, baer2@mail.med.upenn.edu
- Genetics of High HDL
-
- Principal investigator: Dr. Daniel J. Rader
- Contact: Marjorie Risman, baer2@mail.med.upenn.edu
- Effect of Low HDL on Blood Sugar
-
- Principal investigator: Dr. Marina Cuchel
- Contact: Amanda Baer, baer2@mail.med.upenn.edu
Abnormal triglycerides
- Evaluation of Abnormal Plasma Lipid Levels
-
- Principal investigator: Dr. Daniel J. Rader
- Contact: Marjorie Risman, baer2@mail.med.upenn.edu
- Efficacy and Safety of Epanova® in Severe Hypertriglyceridemia
-
- Principal investigator: Dr. Richard L. Dunbar
- Contact: Grace Nathanson, nathansa@mail.med.upenn.edu
Heart attack / Coronary disease
- Biochemical Characteristics of Elevated HDL and Coronary Heart Disease
-
- Principal investigator: Dr. Marina Cuchel
- Contact: Marjorie Risman, risman@mail.med.upenn.edu
- Mechanistic Study of HDL Kinetics in Patients with Elevated HDL
-
- Principal investigator: Dr. Marina Cuchel
- Contact: Amanda Baer, baer2@mail.med.upenn.edu
- Assessment of Vascular Health after Niacin Therapy
-
- Principal investigator: Dr. Emil M. DeGoma
- Contact: Laura Pollan, pollan@mail.med.upenn.edu
- The Complex Genetics Initiative
-
- Principal investigator: Dr. Daniel J. Rader
- Contact: Marjorie Risman, baer2@mail.med.upenn.edu
Peripheral vascular disease
- Assessment of Vascular Health after Niacin Therapy
-
- Principal investigator: Dr. Emil M. DeGoma
- Contact: Laura Pollan, pollan@mail.med.upenn.edu
- Sodium Nitrite in Diabetic Patients with Peripheral Artery Disease
-
- Principal investigator: Dr. Emile R. Mohler
- Contact: Elizabeth Medenilla, Elizabeth.Medenilla@uphs.upenn.edu
- Genetic Information to Guide Anticoagulation Therapy
-
- Principal investigator: Dr. Emile R. Mohler
- Contact: Elizabeth Medenilla, Elizabeth.Medenilla@uphs.upenn.edu
- Safety and Efficacy of GSK1278863 for Peripheral Artery Disease
-
- Principal investigator: Dr. Emile R. Mohler
- Contact: Elizabeth Medenilla, Elizabeth.Medenilla@uphs.upenn.edu
- Genetic Causes of Varicose Veins
-
- Principal investigator: Dr. Emile R. Mohler
- Contact: Elizabeth Medenilla, Elizabeth.Medenilla@uphs.upenn.edu
- MRI Examination for Peripheral Artery Disease
-
- Principal investigator: Dr. Emile R. Mohler
- Contact: Elizabeth Medenilla, Elizabeth.Medenilla@uphs.upenn.edu
Diabetes / High blood glucose
- Sodium Nitrite in Diabetic Patients with Peripheral Artery Disease
-
- Principal investigator: Dr. Emile R. Mohler
- Contact: Elizabeth Medenilla, Elizabeth.Medenilla@uphs.upenn.edu
- Penn Diabetes Heart Study
-
- Principal investigator: Dr. Muredach P. Reilly
- Contact: Karen Terembula, kterembu@mail.med.upenn.edu
High blood pressure
- Lifestyle Modification in Blood Pressure Study (LIMBS)
-
- Principal investigator: Dr. Debbie Cohen
- Contact: Deborah Bouvier, Deborah.bouvier@uphs.upenn.edu
Psoriasis cardiovascular evaluation
- A Descriptive Study to Evaluate Cardiometabolic Risk Factors in Patients with Psoriasis (PSO-D)
-
- Principal investigator: Dr. Nehal Mehta
- Contact: Amanda Baer, baer2@mail.med.upenn.edu
- A Descriptive Study to Evaluate Subclinical Atherosclerosis by FDG PET CT in Patients with Psoriasis, Rheumatoid Arthritis and Psoriatic Arthritis (PSO-CVD)
-
- Principal investigator: Dr. Nehal Mehta
- Contact: Amanda Baer, baer2@mail.med.upenn.edu
- The Vascular Inflammation in Psoriasis Trial (VIP)
-
- Principal investigator: Dr. Nehal Mehta
- Contact: Mackenzie Wilcox, Mackenzie.Wilcox@uphs.upenn.edu
- The Vascular Inflammation in Psoriasis Trial in patients treated with Ustekinumab (VIP-2)
-
- Principal investigator: Dr. Nehal Mehta
- Contact: Mackenzie Wilcox, Mackenzie.Wilcox@uphs.upenn.edu
Need an appointment? Request one online 24 hours/day, 7 days/week or call 800-789-PENN (7366) to speak to a referral counselor.